MicroRNA-based therapy and breast cancer: a comprehensive review of novel therapeutic strategies from diagnosis to treatment
MicroRNAs (miRNA) are 21–23 nucleotide molecules not translated into proteins that bind and target the 3′ untranslated regions of mRNA. These characteristics make them a possible tool for inhibiting protein translation. Different cellular pathways involved in cancer development, such as cellular pro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Academic Press
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/45473/1/DRUG.pdf |
| _version_ | 1796974553585418240 |
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| author | Rahmat, Asmah Ling, King Hwa Ismail, Patimah Kaboli, Parham Jabbarzadeh |
| author_facet | Rahmat, Asmah Ling, King Hwa Ismail, Patimah Kaboli, Parham Jabbarzadeh |
| author_sort | Rahmat, Asmah |
| collection | UPM |
| description | MicroRNAs (miRNA) are 21–23 nucleotide molecules not translated into proteins that bind and target the 3′ untranslated regions of mRNA. These characteristics make them a possible tool for inhibiting protein translation. Different cellular pathways involved in cancer development, such as cellular proliferation, apoptosis, and migration, are regulated by miRNAs. The objective of this review is to discuss various miRNAs involved in breast cancer in detail as well as different therapeutic strategies from the clinic to industry. A comprehensive discussion is provided on various miRNAs involved in breast cancer development, progression, and metastasis as well as the roles, targets, and related therapeutic strategies of different miRNAs associated with breast cancer. miRNAs known to be clinically useful for the diagnosis and prognosis of breast cancer are also discussed. Different strategies and challenges, including nucleic acid-based (miRNA mimics, antagomiRs, and miRNA sponges) and drug-based (drug resistance, drugs/miRNA interaction, nanodelivery, and sensing systems) approaches to suppress specific oncogenes and/or activate target tumor suppressors are discussed. In contrast to other articles written on the same topic, this review focuses on the therapeutic and clinical value of miRNAs as well as their corresponding targets in order to explore how these strategies can overcome breast cancer, which is the second most frequent type of cancer worldwide. This review focuses on promising and validated miRNAs involved in breast cancer. In particular, two miRNAs, miR-21 and miR-34, are discussed as the most promising targets for RNA-based therapy in non-invasive and invasive breast cancer, respectively. Finally, relevant and commercialized therapeutic strategies are highlighted. |
| first_indexed | 2024-03-06T08:58:43Z |
| format | Article |
| id | upm.eprints-45473 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:58:43Z |
| publishDate | 2015 |
| publisher | Academic Press |
| record_format | dspace |
| spelling | upm.eprints-454732021-01-23T22:25:25Z http://psasir.upm.edu.my/id/eprint/45473/ MicroRNA-based therapy and breast cancer: a comprehensive review of novel therapeutic strategies from diagnosis to treatment Rahmat, Asmah Ling, King Hwa Ismail, Patimah Kaboli, Parham Jabbarzadeh MicroRNAs (miRNA) are 21–23 nucleotide molecules not translated into proteins that bind and target the 3′ untranslated regions of mRNA. These characteristics make them a possible tool for inhibiting protein translation. Different cellular pathways involved in cancer development, such as cellular proliferation, apoptosis, and migration, are regulated by miRNAs. The objective of this review is to discuss various miRNAs involved in breast cancer in detail as well as different therapeutic strategies from the clinic to industry. A comprehensive discussion is provided on various miRNAs involved in breast cancer development, progression, and metastasis as well as the roles, targets, and related therapeutic strategies of different miRNAs associated with breast cancer. miRNAs known to be clinically useful for the diagnosis and prognosis of breast cancer are also discussed. Different strategies and challenges, including nucleic acid-based (miRNA mimics, antagomiRs, and miRNA sponges) and drug-based (drug resistance, drugs/miRNA interaction, nanodelivery, and sensing systems) approaches to suppress specific oncogenes and/or activate target tumor suppressors are discussed. In contrast to other articles written on the same topic, this review focuses on the therapeutic and clinical value of miRNAs as well as their corresponding targets in order to explore how these strategies can overcome breast cancer, which is the second most frequent type of cancer worldwide. This review focuses on promising and validated miRNAs involved in breast cancer. In particular, two miRNAs, miR-21 and miR-34, are discussed as the most promising targets for RNA-based therapy in non-invasive and invasive breast cancer, respectively. Finally, relevant and commercialized therapeutic strategies are highlighted. Academic Press 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/45473/1/DRUG.pdf Rahmat, Asmah and Ling, King Hwa and Ismail, Patimah and Kaboli, Parham Jabbarzadeh (2015) MicroRNA-based therapy and breast cancer: a comprehensive review of novel therapeutic strategies from diagnosis to treatment. Pharmacological Research, 97. pp. 104-121. ISSN 1043-6618; ESSN: 1096-1186 https://www.sciencedirect.com/science/article/pii/S1043661815000833 10.1016/j.phrs.2015.04.015 |
| spellingShingle | Rahmat, Asmah Ling, King Hwa Ismail, Patimah Kaboli, Parham Jabbarzadeh MicroRNA-based therapy and breast cancer: a comprehensive review of novel therapeutic strategies from diagnosis to treatment |
| title | MicroRNA-based therapy and breast cancer: a comprehensive review of novel therapeutic strategies from diagnosis to treatment |
| title_full | MicroRNA-based therapy and breast cancer: a comprehensive review of novel therapeutic strategies from diagnosis to treatment |
| title_fullStr | MicroRNA-based therapy and breast cancer: a comprehensive review of novel therapeutic strategies from diagnosis to treatment |
| title_full_unstemmed | MicroRNA-based therapy and breast cancer: a comprehensive review of novel therapeutic strategies from diagnosis to treatment |
| title_short | MicroRNA-based therapy and breast cancer: a comprehensive review of novel therapeutic strategies from diagnosis to treatment |
| title_sort | microrna based therapy and breast cancer a comprehensive review of novel therapeutic strategies from diagnosis to treatment |
| url | http://psasir.upm.edu.my/id/eprint/45473/1/DRUG.pdf |
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