Nanoemulsion-based parenteral drug delivery system of carbamazepine: preparation, characterization, stability evaluation and blood-brain pharmacokinetics
Carbamzepine (CBZ) was encapsulated in a parenteral oil-in-water nanoemulsion, in an attempt to improve its bioavailability. The particle size, polydispersity index and zeta potential were measured using dynamic light scattering. Other parameters such as pH, osmolality, viscosity, drug loading effic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Bentham Science Publishers
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/45574/1/Nanoemulsion-based%20parenteral%20drug%20delivery%20system%20.pdf |
| _version_ | 1796974561175011328 |
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| author | Tan, Sim Ling Stanslas, Johnson Basri, Mahiran Abedi Karjiban, Roghayeh Kirby, Brian P. Sani, Dahiru Basri, Hamidon |
| author_facet | Tan, Sim Ling Stanslas, Johnson Basri, Mahiran Abedi Karjiban, Roghayeh Kirby, Brian P. Sani, Dahiru Basri, Hamidon |
| author_sort | Tan, Sim Ling |
| collection | UPM |
| description | Carbamzepine (CBZ) was encapsulated in a parenteral oil-in-water nanoemulsion, in an attempt to improve its bioavailability. The particle size, polydispersity index and zeta potential were measured using dynamic light scattering. Other parameters such as pH, osmolality, viscosity, drug loading efficiency and entrapment efficiency were also recorded. Transmission electron microscopy revealed that emulsion droplets were almost spherical in shape and in the nano-range. The in vitro release profile was best characterized by Higuchi's equation. The parenteral nanoemulsion of CBZ showed significantly higher AUC0→5, AUC0→∞, AUMC0→5, AUMC0→∞, Cmax and lower clearance than that of CBZ solution in plasma. Additionally, parenteral nanoemulsion of CBZ showed significantly higher AUC0→∞, AUMC0→∞ and Cmaxthan that of CBZ solution in brain. The parenteral nanoemulsion of CBZ could therefore use as a carrier, worth exploring further for brain targeting. |
| first_indexed | 2024-03-06T08:58:50Z |
| format | Article |
| id | upm.eprints-45574 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:58:50Z |
| publishDate | 2015 |
| publisher | Bentham Science Publishers |
| record_format | dspace |
| spelling | upm.eprints-455742021-04-22T07:44:25Z http://psasir.upm.edu.my/id/eprint/45574/ Nanoemulsion-based parenteral drug delivery system of carbamazepine: preparation, characterization, stability evaluation and blood-brain pharmacokinetics Tan, Sim Ling Stanslas, Johnson Basri, Mahiran Abedi Karjiban, Roghayeh Kirby, Brian P. Sani, Dahiru Basri, Hamidon Carbamzepine (CBZ) was encapsulated in a parenteral oil-in-water nanoemulsion, in an attempt to improve its bioavailability. The particle size, polydispersity index and zeta potential were measured using dynamic light scattering. Other parameters such as pH, osmolality, viscosity, drug loading efficiency and entrapment efficiency were also recorded. Transmission electron microscopy revealed that emulsion droplets were almost spherical in shape and in the nano-range. The in vitro release profile was best characterized by Higuchi's equation. The parenteral nanoemulsion of CBZ showed significantly higher AUC0→5, AUC0→∞, AUMC0→5, AUMC0→∞, Cmax and lower clearance than that of CBZ solution in plasma. Additionally, parenteral nanoemulsion of CBZ showed significantly higher AUC0→∞, AUMC0→∞ and Cmaxthan that of CBZ solution in brain. The parenteral nanoemulsion of CBZ could therefore use as a carrier, worth exploring further for brain targeting. Bentham Science Publishers 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/45574/1/Nanoemulsion-based%20parenteral%20drug%20delivery%20system%20.pdf Tan, Sim Ling and Stanslas, Johnson and Basri, Mahiran and Abedi Karjiban, Roghayeh and Kirby, Brian P. and Sani, Dahiru and Basri, Hamidon (2015) Nanoemulsion-based parenteral drug delivery system of carbamazepine: preparation, characterization, stability evaluation and blood-brain pharmacokinetics. Current Drug Delivery, 12 (6). pp. 795-804. ISSN 1567-2018 https://pubmed.ncbi.nlm.nih.gov/26324229/ 10.2174/1567201812666150901112544 |
| spellingShingle | Tan, Sim Ling Stanslas, Johnson Basri, Mahiran Abedi Karjiban, Roghayeh Kirby, Brian P. Sani, Dahiru Basri, Hamidon Nanoemulsion-based parenteral drug delivery system of carbamazepine: preparation, characterization, stability evaluation and blood-brain pharmacokinetics |
| title | Nanoemulsion-based parenteral drug delivery system of carbamazepine: preparation, characterization, stability evaluation and blood-brain pharmacokinetics |
| title_full | Nanoemulsion-based parenteral drug delivery system of carbamazepine: preparation, characterization, stability evaluation and blood-brain pharmacokinetics |
| title_fullStr | Nanoemulsion-based parenteral drug delivery system of carbamazepine: preparation, characterization, stability evaluation and blood-brain pharmacokinetics |
| title_full_unstemmed | Nanoemulsion-based parenteral drug delivery system of carbamazepine: preparation, characterization, stability evaluation and blood-brain pharmacokinetics |
| title_short | Nanoemulsion-based parenteral drug delivery system of carbamazepine: preparation, characterization, stability evaluation and blood-brain pharmacokinetics |
| title_sort | nanoemulsion based parenteral drug delivery system of carbamazepine preparation characterization stability evaluation and blood brain pharmacokinetics |
| url | http://psasir.upm.edu.my/id/eprint/45574/1/Nanoemulsion-based%20parenteral%20drug%20delivery%20system%20.pdf |
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