Naturally-occurring glucosinolates, glucoraphanin and glucoerucin, are antagonists to aryl hydrocarbon receptor as their chemopreventive potency
As a cytosolic transcription factor, the aryl hydrocarbon (Ah) receptor is involved in several patho- physiological events leading to immunosuppression and cancer; hence antagonists of the Ah receptor may possess chemoprevention properties. It is known to modulate carcinogen-metabolising enzymes, fo...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Asian Pacific Organization for Cancer Prevention
2015
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/45581/1/AR.pdf |
| _version_ | 1825929582466826240 |
|---|---|
| author | Abdull Razis, Ahmad Faizal Mohd Noor, Noramaliza |
| author_facet | Abdull Razis, Ahmad Faizal Mohd Noor, Noramaliza |
| author_sort | Abdull Razis, Ahmad Faizal |
| collection | UPM |
| description | As a cytosolic transcription factor, the aryl hydrocarbon (Ah) receptor is involved in several patho- physiological events leading to immunosuppression and cancer; hence antagonists of the Ah receptor may possess chemoprevention properties. It is known to modulate carcinogen-metabolising enzymes, for instance the CYP1 family of cytochromes P450 and quinone reductase, both important in the biotransformation of many chemical carcinogens via regulating phase I and phase II enzyme systems. Utilising chemically-activated luciferase expression (CALUX) assay it was revealed that intact glucosinolates, glucoraphanin and glucoerucin, isolated from Brassica oleracea L. var. acephala sabellica and Eruca sativa ripe seeds, respectively, are such antagonists. Both glucosinolates were poor ligands for the Ah receptor; however, they effectively antagonised activation of the receptor by the avid ligand benzo[a]pyrene. Indeed, intact glucosinolate glucoraphanin was a more potent antagonist to the receptor than glucoerucin. It can be concluded that both glucosinolates effectively act as antagonists for the Ah receptor, and this may contribute to their established chemoprevention potency. |
| first_indexed | 2024-03-06T08:58:50Z |
| format | Article |
| id | upm.eprints-45581 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:58:50Z |
| publishDate | 2015 |
| publisher | Asian Pacific Organization for Cancer Prevention |
| record_format | dspace |
| spelling | upm.eprints-455812021-01-23T22:31:09Z http://psasir.upm.edu.my/id/eprint/45581/ Naturally-occurring glucosinolates, glucoraphanin and glucoerucin, are antagonists to aryl hydrocarbon receptor as their chemopreventive potency Abdull Razis, Ahmad Faizal Mohd Noor, Noramaliza As a cytosolic transcription factor, the aryl hydrocarbon (Ah) receptor is involved in several patho- physiological events leading to immunosuppression and cancer; hence antagonists of the Ah receptor may possess chemoprevention properties. It is known to modulate carcinogen-metabolising enzymes, for instance the CYP1 family of cytochromes P450 and quinone reductase, both important in the biotransformation of many chemical carcinogens via regulating phase I and phase II enzyme systems. Utilising chemically-activated luciferase expression (CALUX) assay it was revealed that intact glucosinolates, glucoraphanin and glucoerucin, isolated from Brassica oleracea L. var. acephala sabellica and Eruca sativa ripe seeds, respectively, are such antagonists. Both glucosinolates were poor ligands for the Ah receptor; however, they effectively antagonised activation of the receptor by the avid ligand benzo[a]pyrene. Indeed, intact glucosinolate glucoraphanin was a more potent antagonist to the receptor than glucoerucin. It can be concluded that both glucosinolates effectively act as antagonists for the Ah receptor, and this may contribute to their established chemoprevention potency. Asian Pacific Organization for Cancer Prevention 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/45581/1/AR.pdf Abdull Razis, Ahmad Faizal and Mohd Noor, Noramaliza (2015) Naturally-occurring glucosinolates, glucoraphanin and glucoerucin, are antagonists to aryl hydrocarbon receptor as their chemopreventive potency. Asian Pacific Journal of Cancer Prevention, 16 (14). pp. 5801-5805. ISSN 1513-7368 https://pubmed.ncbi.nlm.nih.gov/26320454/ 10.7314/apjcp.2015.16.14.5801 |
| spellingShingle | Abdull Razis, Ahmad Faizal Mohd Noor, Noramaliza Naturally-occurring glucosinolates, glucoraphanin and glucoerucin, are antagonists to aryl hydrocarbon receptor as their chemopreventive potency |
| title | Naturally-occurring glucosinolates, glucoraphanin and glucoerucin, are antagonists to aryl hydrocarbon receptor as their chemopreventive potency |
| title_full | Naturally-occurring glucosinolates, glucoraphanin and glucoerucin, are antagonists to aryl hydrocarbon receptor as their chemopreventive potency |
| title_fullStr | Naturally-occurring glucosinolates, glucoraphanin and glucoerucin, are antagonists to aryl hydrocarbon receptor as their chemopreventive potency |
| title_full_unstemmed | Naturally-occurring glucosinolates, glucoraphanin and glucoerucin, are antagonists to aryl hydrocarbon receptor as their chemopreventive potency |
| title_short | Naturally-occurring glucosinolates, glucoraphanin and glucoerucin, are antagonists to aryl hydrocarbon receptor as their chemopreventive potency |
| title_sort | naturally occurring glucosinolates glucoraphanin and glucoerucin are antagonists to aryl hydrocarbon receptor as their chemopreventive potency |
| url | http://psasir.upm.edu.my/id/eprint/45581/1/AR.pdf |
| work_keys_str_mv | AT abdullrazisahmadfaizal naturallyoccurringglucosinolatesglucoraphaninandglucoerucinareantagoniststoarylhydrocarbonreceptorastheirchemopreventivepotency AT mohdnoornoramaliza naturallyoccurringglucosinolatesglucoraphaninandglucoerucinareantagoniststoarylhydrocarbonreceptorastheirchemopreventivepotency |