Xanthone from Garcinia eugenifolia (Clusiaceae)
Studies on the twigs of Garcinia eugenifolia have led to the isolation of one xanthone 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)pyrano[3,2-b]xanthen-6(2H)-one (1) and one triterpenoid, sitosterol (2). Meanwhile, studies on the leaves of Garcinia eugenifolia provided another triterp...
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| Format: | Conference or Workshop Item |
| Language: | English |
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IEEE
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/45685/1/Xanthone%20from%20Garcinia%20eugenifolia%20%28Clusiaceae%29.pdf |
| _version_ | 1825929589106409472 |
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| author | Jong, Vivien Yi Mian Ee, Gwendoline Cheng Lian Khong, Heng Yen |
| author_facet | Jong, Vivien Yi Mian Ee, Gwendoline Cheng Lian Khong, Heng Yen |
| author_sort | Jong, Vivien Yi Mian |
| collection | UPM |
| description | Studies on the twigs of Garcinia eugenifolia have led to the isolation of one xanthone 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)pyrano[3,2-b]xanthen-6(2H)-one (1) and one triterpenoid, sitosterol (2). Meanwhile, studies on the leaves of Garcinia eugenifolia provided another triterpenoid, friedelin (3). The structures of these compounds were determined by spectroscopic methods such as 1H NMR, 13C NMR, mass spectrometry (MS) and by comparison with previous studies. The hexane and ethyl acetate extracts of Garcinia eugenifolia indicated strong cytotoxicity towards the HL-60 cell line with IC50 values of 1.9 μg/ml and 2.5 μg/ml respectively. However, the methanol extract gave moderate inhibitory activities (IC50<10 μg/ml) towards HL-60 cell line. |
| first_indexed | 2024-03-06T08:58:56Z |
| format | Conference or Workshop Item |
| id | upm.eprints-45685 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:58:56Z |
| publishDate | 2010 |
| publisher | IEEE |
| record_format | dspace |
| spelling | upm.eprints-456852020-08-07T02:27:53Z http://psasir.upm.edu.my/id/eprint/45685/ Xanthone from Garcinia eugenifolia (Clusiaceae) Jong, Vivien Yi Mian Ee, Gwendoline Cheng Lian Khong, Heng Yen Studies on the twigs of Garcinia eugenifolia have led to the isolation of one xanthone 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)pyrano[3,2-b]xanthen-6(2H)-one (1) and one triterpenoid, sitosterol (2). Meanwhile, studies on the leaves of Garcinia eugenifolia provided another triterpenoid, friedelin (3). The structures of these compounds were determined by spectroscopic methods such as 1H NMR, 13C NMR, mass spectrometry (MS) and by comparison with previous studies. The hexane and ethyl acetate extracts of Garcinia eugenifolia indicated strong cytotoxicity towards the HL-60 cell line with IC50 values of 1.9 μg/ml and 2.5 μg/ml respectively. However, the methanol extract gave moderate inhibitory activities (IC50<10 μg/ml) towards HL-60 cell line. IEEE 2010 Conference or Workshop Item PeerReviewed text en http://psasir.upm.edu.my/id/eprint/45685/1/Xanthone%20from%20Garcinia%20eugenifolia%20%28Clusiaceae%29.pdf Jong, Vivien Yi Mian and Ee, Gwendoline Cheng Lian and Khong, Heng Yen (2010) Xanthone from Garcinia eugenifolia (Clusiaceae). In: 2010 International Conference on Science and Social Research (CSSR 2010), 5-7 Dec. 2010, Seri Pacific Hotel, Kuala Lumpur, Malaysia. (pp. 786-788). 10.1109/CSSR.2010.5773892 |
| spellingShingle | Jong, Vivien Yi Mian Ee, Gwendoline Cheng Lian Khong, Heng Yen Xanthone from Garcinia eugenifolia (Clusiaceae) |
| title | Xanthone from Garcinia eugenifolia (Clusiaceae) |
| title_full | Xanthone from Garcinia eugenifolia (Clusiaceae) |
| title_fullStr | Xanthone from Garcinia eugenifolia (Clusiaceae) |
| title_full_unstemmed | Xanthone from Garcinia eugenifolia (Clusiaceae) |
| title_short | Xanthone from Garcinia eugenifolia (Clusiaceae) |
| title_sort | xanthone from garcinia eugenifolia clusiaceae |
| url | http://psasir.upm.edu.my/id/eprint/45685/1/Xanthone%20from%20Garcinia%20eugenifolia%20%28Clusiaceae%29.pdf |
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