Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles
Nanoparticle sulphated zirconia with Brønsted acidic sites were prepared here by an impregnation reaction followed by calcination at 600°C for 3 hours. The characterization was completed using X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, Brunner-Emmett-Te...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/45852/1/ZIRCONIA.pdf |
| _version_ | 1796974583944839168 |
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| author | Yap, Taufiq Yun Hin Abdullah, Rasedee Mftah, Ae Alhassan, Fatah H. El Zowalaty, Mohamed Ezzat Webster, Thomas Jay Sh-Eldin, Mohammed Ali Rashid, Shah Samiur Al-Qubaisi, Mothanna Sadiq |
| author_facet | Yap, Taufiq Yun Hin Abdullah, Rasedee Mftah, Ae Alhassan, Fatah H. El Zowalaty, Mohamed Ezzat Webster, Thomas Jay Sh-Eldin, Mohammed Ali Rashid, Shah Samiur Al-Qubaisi, Mothanna Sadiq |
| author_sort | Yap, Taufiq Yun Hin |
| collection | UPM |
| description | Nanoparticle sulphated zirconia with Brønsted acidic sites were prepared here by an impregnation reaction followed by calcination at 600°C for 3 hours. The characterization was completed using X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, Brunner-Emmett-Teller surface area measurements, scanning electron microscopy with energy dispersive X-ray spectroscopy, and transmission electron microscopy. Moreover, the anticancer and antimicrobial effects were investigated for the first time. This study showed for the first time that the exposure of cancer cells to sulphated zirconia nanoparticles (3.9–1,000 μg/mL for 24 hours) resulted in a dose-dependent inhibition of cell growth, as determined by (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Similar promising results were observed for reducing bacteria functions. In this manner, this study demonstrated that sulphated zirconia nanoparticles with Brønsted acidic sites should be further studied for a wide range of anticancer and antibacterial applications. |
| first_indexed | 2024-03-06T08:59:10Z |
| format | Article |
| id | upm.eprints-45852 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:59:10Z |
| publishDate | 2015 |
| publisher | Dove Medical Press |
| record_format | dspace |
| spelling | upm.eprints-458522021-01-21T16:27:49Z http://psasir.upm.edu.my/id/eprint/45852/ Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles Yap, Taufiq Yun Hin Abdullah, Rasedee Mftah, Ae Alhassan, Fatah H. El Zowalaty, Mohamed Ezzat Webster, Thomas Jay Sh-Eldin, Mohammed Ali Rashid, Shah Samiur Al-Qubaisi, Mothanna Sadiq Nanoparticle sulphated zirconia with Brønsted acidic sites were prepared here by an impregnation reaction followed by calcination at 600°C for 3 hours. The characterization was completed using X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, Brunner-Emmett-Teller surface area measurements, scanning electron microscopy with energy dispersive X-ray spectroscopy, and transmission electron microscopy. Moreover, the anticancer and antimicrobial effects were investigated for the first time. This study showed for the first time that the exposure of cancer cells to sulphated zirconia nanoparticles (3.9–1,000 μg/mL for 24 hours) resulted in a dose-dependent inhibition of cell growth, as determined by (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Similar promising results were observed for reducing bacteria functions. In this manner, this study demonstrated that sulphated zirconia nanoparticles with Brønsted acidic sites should be further studied for a wide range of anticancer and antibacterial applications. Dove Medical Press 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/45852/1/ZIRCONIA.pdf Yap, Taufiq Yun Hin and Abdullah, Rasedee and Mftah, Ae and Alhassan, Fatah H. and El Zowalaty, Mohamed Ezzat and Webster, Thomas Jay and Sh-Eldin, Mohammed Ali and Rashid, Shah Samiur and Al-Qubaisi, Mothanna Sadiq (2015) Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles. International Journal of Nanomedicine, 10. pp. 765-774. ISSN 1178-2013; ESSN: 1176-9114 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304593/ 10.2147/IJN.S66058 |
| spellingShingle | Yap, Taufiq Yun Hin Abdullah, Rasedee Mftah, Ae Alhassan, Fatah H. El Zowalaty, Mohamed Ezzat Webster, Thomas Jay Sh-Eldin, Mohammed Ali Rashid, Shah Samiur Al-Qubaisi, Mothanna Sadiq Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles |
| title | Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles |
| title_full | Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles |
| title_fullStr | Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles |
| title_full_unstemmed | Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles |
| title_short | Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles |
| title_sort | physicochemical properties cytotoxicity and antimicrobial activity of sulphated zirconia nanoparticles |
| url | http://psasir.upm.edu.my/id/eprint/45852/1/ZIRCONIA.pdf |
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