Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities
Background: Pharmacogenetics is the study of genetic polymorphisms affecting responses to drug therapy. The common rs7903146 (C.T) polymorphism of the TCF7L2 gene has recently been associated with type 2 diabetes (T2D). In this study, prevalence of the rs7903146 (C.T) polymorphism in the TCF7L2 gene...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/45993/1/Prevalence%20of%20the%20rs7903146CT%20polymorphism%20in%20TCF7L2%20gene%20for%20prediction%20of%20type%202%20diabetes%20risk%20among%20Iranians%20of%20different%20ethnicities.pdf |
| _version_ | 1825929624186519552 |
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| author | Allahdini, Mojgan Kamalidehghan, Behnam Akbari, Leila Azadfar, Parisa Rahmani, Ali Ahmadipour, Fatemeh Goh, Yong Meng Masserrat, Abbas Houshmand, Massoud |
| author_facet | Allahdini, Mojgan Kamalidehghan, Behnam Akbari, Leila Azadfar, Parisa Rahmani, Ali Ahmadipour, Fatemeh Goh, Yong Meng Masserrat, Abbas Houshmand, Massoud |
| author_sort | Allahdini, Mojgan |
| collection | UPM |
| description | Background: Pharmacogenetics is the study of genetic polymorphisms affecting responses to drug therapy. The common rs7903146 (C.T) polymorphism of the TCF7L2 gene has recently been associated with type 2 diabetes (T2D). In this study, prevalence of the rs7903146 (C.T) polymorphism in the TCF7L2 gene for prediction of T2D risk was examined in an Iranian population of different ethnicities. Methods: The prevalence of rs7903146 (C.T) and the predicted phenotypes, including extensive metabolizers, intermediate metabolizers, and poor metabolizers were investigated in blood samples of 300 unrelated healthy individuals in an Iranian population, including Fars, Turk, Lure, and Kurd, using polymerase chain reaction restriction fragment length polymorphism and direct genomic DNA sequencing. Results: The homozygous wild-type (C/C), heterozygous (C/T), and homozygous (T/T) allelic frequencies of rs7903146 (C.T) in the TCF7L2 gene were 29% (extensive metabolizers), 66.34% (intermediate metabolizers), and 4.66% (poor metabolizers), respectively. The C/C, C/T, and T/T genotypic frequencies of the rs7903146 (C.T) allele were significantly different (P,0.01) among Iranians of different ethnicities. The frequency of the homozygous T/T variant of the rs7903146 (C.T) allele was significantly low in the Lure (P,0.01) and high in the Fars (P,0.001) ethnicities. Additionally, the frequency of the T/T variant of the rs7903146 (C.T) allele in the South of Iran was the highest (P,0.04), while the East of Iran had the lowest frequency (P,0.01). Conclusion: The prediction of rs7903146 (C.T) is required in drug research and routine treatment, where the information would be helpful for clinicians to optimize therapy and adverse drug reactions and predict drug response in individuals at risk of T2D. |
| first_indexed | 2024-03-06T08:59:26Z |
| format | Article |
| id | upm.eprints-45993 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:59:26Z |
| publishDate | 2015 |
| publisher | Dove Medical Press |
| record_format | dspace |
| spelling | upm.eprints-459932022-05-19T01:39:26Z http://psasir.upm.edu.my/id/eprint/45993/ Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities Allahdini, Mojgan Kamalidehghan, Behnam Akbari, Leila Azadfar, Parisa Rahmani, Ali Ahmadipour, Fatemeh Goh, Yong Meng Masserrat, Abbas Houshmand, Massoud Background: Pharmacogenetics is the study of genetic polymorphisms affecting responses to drug therapy. The common rs7903146 (C.T) polymorphism of the TCF7L2 gene has recently been associated with type 2 diabetes (T2D). In this study, prevalence of the rs7903146 (C.T) polymorphism in the TCF7L2 gene for prediction of T2D risk was examined in an Iranian population of different ethnicities. Methods: The prevalence of rs7903146 (C.T) and the predicted phenotypes, including extensive metabolizers, intermediate metabolizers, and poor metabolizers were investigated in blood samples of 300 unrelated healthy individuals in an Iranian population, including Fars, Turk, Lure, and Kurd, using polymerase chain reaction restriction fragment length polymorphism and direct genomic DNA sequencing. Results: The homozygous wild-type (C/C), heterozygous (C/T), and homozygous (T/T) allelic frequencies of rs7903146 (C.T) in the TCF7L2 gene were 29% (extensive metabolizers), 66.34% (intermediate metabolizers), and 4.66% (poor metabolizers), respectively. The C/C, C/T, and T/T genotypic frequencies of the rs7903146 (C.T) allele were significantly different (P,0.01) among Iranians of different ethnicities. The frequency of the homozygous T/T variant of the rs7903146 (C.T) allele was significantly low in the Lure (P,0.01) and high in the Fars (P,0.001) ethnicities. Additionally, the frequency of the T/T variant of the rs7903146 (C.T) allele in the South of Iran was the highest (P,0.04), while the East of Iran had the lowest frequency (P,0.01). Conclusion: The prediction of rs7903146 (C.T) is required in drug research and routine treatment, where the information would be helpful for clinicians to optimize therapy and adverse drug reactions and predict drug response in individuals at risk of T2D. Dove Medical Press 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/45993/1/Prevalence%20of%20the%20rs7903146CT%20polymorphism%20in%20TCF7L2%20gene%20for%20prediction%20of%20type%202%20diabetes%20risk%20among%20Iranians%20of%20different%20ethnicities.pdf Allahdini, Mojgan and Kamalidehghan, Behnam and Akbari, Leila and Azadfar, Parisa and Rahmani, Ali and Ahmadipour, Fatemeh and Goh, Yong Meng and Masserrat, Abbas and Houshmand, Massoud (2015) Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities. Drug Design, Development and Therapy, 2015. art. no. 9. pp. 5835-5841. ISSN 1177-8881 https://www.dovepress.com/prevalence-of-the-rs7903146cgtt-polymorphism-in-tcf7l2-gene-for-predic-peer-reviewed-fulltext-article-DDDT 10.2147/DDDT.S82485 |
| spellingShingle | Allahdini, Mojgan Kamalidehghan, Behnam Akbari, Leila Azadfar, Parisa Rahmani, Ali Ahmadipour, Fatemeh Goh, Yong Meng Masserrat, Abbas Houshmand, Massoud Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities |
| title | Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities |
| title_full | Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities |
| title_fullStr | Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities |
| title_full_unstemmed | Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities |
| title_short | Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities |
| title_sort | prevalence of the rs7903146c t polymorphism in tcf7l2 gene for prediction of type 2 diabetes risk among iranians of different ethnicities |
| url | http://psasir.upm.edu.my/id/eprint/45993/1/Prevalence%20of%20the%20rs7903146CT%20polymorphism%20in%20TCF7L2%20gene%20for%20prediction%20of%20type%202%20diabetes%20risk%20among%20Iranians%20of%20different%20ethnicities.pdf |
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