RCMV ALL-03 model and study of CMV pathogenesis in congenital infection
Cytomegalovirus (CMV) is one of the most commonly studied members of the Herpesviridae family. So far several strains have been identified but human CMV (HCMV) remains the most important due to its ability to infect humans and also cross the placenta causing neonatal infection and mortality. However...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Science Publications
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/46083/1/RCMV%20ALL-03%20model%20and%20study%20of%20CMV%20pathogenesis%20in%20congenital%20infection.pdf |
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| author | Abdullah, Ashwaq Ahmed Balakrishnan, Krishnan Nair Abba, Yusuf Jesse A, Faez Firdaus Allaudin Nazariah, Zeenathul Abdullah, Rasedee M Mustapha, Noordin Mohd Lila, Mohd Azmi |
| author_facet | Abdullah, Ashwaq Ahmed Balakrishnan, Krishnan Nair Abba, Yusuf Jesse A, Faez Firdaus Allaudin Nazariah, Zeenathul Abdullah, Rasedee M Mustapha, Noordin Mohd Lila, Mohd Azmi |
| author_sort | Abdullah, Ashwaq Ahmed |
| collection | UPM |
| description | Cytomegalovirus (CMV) is one of the most commonly studied members of the Herpesviridae family. So far several strains have been identified but human CMV (HCMV) remains the most important due to its ability to infect humans and also cross the placenta causing neonatal infection and mortality. However, there are several limitations in the study of this strain which includes availability and use of model animals. Although strains such as Rhesus CMV (RhCMV), Guinea pig CMV (GPCMV) and Rat CMV (RCMV ALL-03) have been shown to cross the placenta and exhibit similar pathogenesis to HCMV, only RCMV ALL-03 can be conveniently used without much limitations as guinea pigs are resistant to antiviral drugs, while rhesus monkeys are seropositive, considered costly and have ethical use restrictions. We therefore propose the use of RCMV ALL-03 as a model for the study of CMV infection. |
| first_indexed | 2024-03-06T08:59:38Z |
| format | Article |
| id | upm.eprints-46083 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:59:38Z |
| publishDate | 2015 |
| publisher | Science Publications |
| record_format | dspace |
| spelling | upm.eprints-460832022-03-23T04:26:31Z http://psasir.upm.edu.my/id/eprint/46083/ RCMV ALL-03 model and study of CMV pathogenesis in congenital infection Abdullah, Ashwaq Ahmed Balakrishnan, Krishnan Nair Abba, Yusuf Jesse A, Faez Firdaus Allaudin Nazariah, Zeenathul Abdullah, Rasedee M Mustapha, Noordin Mohd Lila, Mohd Azmi Cytomegalovirus (CMV) is one of the most commonly studied members of the Herpesviridae family. So far several strains have been identified but human CMV (HCMV) remains the most important due to its ability to infect humans and also cross the placenta causing neonatal infection and mortality. However, there are several limitations in the study of this strain which includes availability and use of model animals. Although strains such as Rhesus CMV (RhCMV), Guinea pig CMV (GPCMV) and Rat CMV (RCMV ALL-03) have been shown to cross the placenta and exhibit similar pathogenesis to HCMV, only RCMV ALL-03 can be conveniently used without much limitations as guinea pigs are resistant to antiviral drugs, while rhesus monkeys are seropositive, considered costly and have ethical use restrictions. We therefore propose the use of RCMV ALL-03 as a model for the study of CMV infection. Science Publications 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/46083/1/RCMV%20ALL-03%20model%20and%20study%20of%20CMV%20pathogenesis%20in%20congenital%20infection.pdf Abdullah, Ashwaq Ahmed and Balakrishnan, Krishnan Nair and Abba, Yusuf and Jesse A, Faez Firdaus and Allaudin Nazariah, Zeenathul and Abdullah, Rasedee and M Mustapha, Noordin and Mohd Lila, Mohd Azmi (2015) RCMV ALL-03 model and study of CMV pathogenesis in congenital infection. American Journal of Animal and Veterinary Sciences, 10 (3). pp. 170-186. ISSN 1557-4555; ESSN: 1557-4563 https://thescipub.com/abstract/10.3844/ajavsp.2015.170.186 10.3844/ajavsp.2015.170.186 |
| spellingShingle | Abdullah, Ashwaq Ahmed Balakrishnan, Krishnan Nair Abba, Yusuf Jesse A, Faez Firdaus Allaudin Nazariah, Zeenathul Abdullah, Rasedee M Mustapha, Noordin Mohd Lila, Mohd Azmi RCMV ALL-03 model and study of CMV pathogenesis in congenital infection |
| title | RCMV ALL-03 model and study of CMV pathogenesis in congenital infection |
| title_full | RCMV ALL-03 model and study of CMV pathogenesis in congenital infection |
| title_fullStr | RCMV ALL-03 model and study of CMV pathogenesis in congenital infection |
| title_full_unstemmed | RCMV ALL-03 model and study of CMV pathogenesis in congenital infection |
| title_short | RCMV ALL-03 model and study of CMV pathogenesis in congenital infection |
| title_sort | rcmv all 03 model and study of cmv pathogenesis in congenital infection |
| url | http://psasir.upm.edu.my/id/eprint/46083/1/RCMV%20ALL-03%20model%20and%20study%20of%20CMV%20pathogenesis%20in%20congenital%20infection.pdf |
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