Tumor suppression effect of Solanum nigrum polysaccharide fraction on breast cancer animal model via immunomodulation
A polysaccharide fraction from Solanum nigrum, SN-ppF3 was shown previously to have an immunomodulatory activity where it could possibly be used to enhance the host immune response in fighting cancer. The non-toxic SN-ppF3 was fed orally to breast tumor bearing-mice with concentrations of 250 and 50...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/46777/1/Tumor%20suppression%20effect%20of%20Solanum%20nigrum%20polysaccharide%20fraction%20on%20breast%20cancer%20animal%20model%20via%20immunomodulation.pdf |
| _version_ | 1825929744620716032 |
|---|---|
| author | Razali, Faizan Naeem Sinniah, Saravana Kumar Hussin, Huzlinda Zainal Abidin, Nurhayati Shuib, Adawiyah Suriza |
| author_facet | Razali, Faizan Naeem Sinniah, Saravana Kumar Hussin, Huzlinda Zainal Abidin, Nurhayati Shuib, Adawiyah Suriza |
| author_sort | Razali, Faizan Naeem |
| collection | UPM |
| description | A polysaccharide fraction from Solanum nigrum, SN-ppF3 was shown previously to have an immunomodulatory activity where it could possibly be used to enhance the host immune response in fighting cancer. The non-toxic SN-ppF3 was fed orally to breast tumor bearing-mice with concentrations of 250 and 500mg/kg for 10days. During the treatment period, size of the tumor and weight of the mice were monitored. At the end of the treatment, blood, tumor, spleen and thymus were harvested for physiological and immunological analyses. After the treatment, the tumor volume and tumor weight were significantly inhibited by 65% and 40%, respectively. Based on the histological observation, the treatment of SN-ppF3 resulted in the disruption of tumor cells morphology. The increase in infiltrating T cells, NK cells and macrophages were observed in tumor tissues of the treated mice, which partly explained the higher apoptosis tumor cells observed in the treated mice. Moreover, the level of TNF-α, IFN-γ and IL-4 were elevated, while the level of IL-6 was decreased significantly, in serum of the treated mice. These results suggested that tumor suppression mechanisms observed in SN-ppF3-treated mice were most probably due through enhancing the host immune response. |
| first_indexed | 2024-03-06T09:01:12Z |
| format | Article |
| id | upm.eprints-46777 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:01:12Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-467772022-05-25T04:09:29Z http://psasir.upm.edu.my/id/eprint/46777/ Tumor suppression effect of Solanum nigrum polysaccharide fraction on breast cancer animal model via immunomodulation Razali, Faizan Naeem Sinniah, Saravana Kumar Hussin, Huzlinda Zainal Abidin, Nurhayati Shuib, Adawiyah Suriza A polysaccharide fraction from Solanum nigrum, SN-ppF3 was shown previously to have an immunomodulatory activity where it could possibly be used to enhance the host immune response in fighting cancer. The non-toxic SN-ppF3 was fed orally to breast tumor bearing-mice with concentrations of 250 and 500mg/kg for 10days. During the treatment period, size of the tumor and weight of the mice were monitored. At the end of the treatment, blood, tumor, spleen and thymus were harvested for physiological and immunological analyses. After the treatment, the tumor volume and tumor weight were significantly inhibited by 65% and 40%, respectively. Based on the histological observation, the treatment of SN-ppF3 resulted in the disruption of tumor cells morphology. The increase in infiltrating T cells, NK cells and macrophages were observed in tumor tissues of the treated mice, which partly explained the higher apoptosis tumor cells observed in the treated mice. Moreover, the level of TNF-α, IFN-γ and IL-4 were elevated, while the level of IL-6 was decreased significantly, in serum of the treated mice. These results suggested that tumor suppression mechanisms observed in SN-ppF3-treated mice were most probably due through enhancing the host immune response. Elsevier 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/46777/1/Tumor%20suppression%20effect%20of%20Solanum%20nigrum%20polysaccharide%20fraction%20on%20breast%20cancer%20animal%20model%20via%20immunomodulation.pdf Razali, Faizan Naeem and Sinniah, Saravana Kumar and Hussin, Huzlinda and Zainal Abidin, Nurhayati and Shuib, Adawiyah Suriza (2016) Tumor suppression effect of Solanum nigrum polysaccharide fraction on breast cancer animal model via immunomodulation. Phytomedicine, 92. pp. 185-193. ISSN 0944-7113; ESSN: 1618-095X https://www.sciencedirect.com/science/article/pii/S0141813016306262?via%3Dihub 10.1016/j.ijbiomac.2016.06.079 |
| spellingShingle | Razali, Faizan Naeem Sinniah, Saravana Kumar Hussin, Huzlinda Zainal Abidin, Nurhayati Shuib, Adawiyah Suriza Tumor suppression effect of Solanum nigrum polysaccharide fraction on breast cancer animal model via immunomodulation |
| title | Tumor suppression effect of Solanum nigrum polysaccharide fraction on breast cancer animal model via immunomodulation |
| title_full | Tumor suppression effect of Solanum nigrum polysaccharide fraction on breast cancer animal model via immunomodulation |
| title_fullStr | Tumor suppression effect of Solanum nigrum polysaccharide fraction on breast cancer animal model via immunomodulation |
| title_full_unstemmed | Tumor suppression effect of Solanum nigrum polysaccharide fraction on breast cancer animal model via immunomodulation |
| title_short | Tumor suppression effect of Solanum nigrum polysaccharide fraction on breast cancer animal model via immunomodulation |
| title_sort | tumor suppression effect of solanum nigrum polysaccharide fraction on breast cancer animal model via immunomodulation |
| url | http://psasir.upm.edu.my/id/eprint/46777/1/Tumor%20suppression%20effect%20of%20Solanum%20nigrum%20polysaccharide%20fraction%20on%20breast%20cancer%20animal%20model%20via%20immunomodulation.pdf |
| work_keys_str_mv | AT razalifaizannaeem tumorsuppressioneffectofsolanumnigrumpolysaccharidefractiononbreastcanceranimalmodelviaimmunomodulation AT sinniahsaravanakumar tumorsuppressioneffectofsolanumnigrumpolysaccharidefractiononbreastcanceranimalmodelviaimmunomodulation AT hussinhuzlinda tumorsuppressioneffectofsolanumnigrumpolysaccharidefractiononbreastcanceranimalmodelviaimmunomodulation AT zainalabidinnurhayati tumorsuppressioneffectofsolanumnigrumpolysaccharidefractiononbreastcanceranimalmodelviaimmunomodulation AT shuibadawiyahsuriza tumorsuppressioneffectofsolanumnigrumpolysaccharidefractiononbreastcanceranimalmodelviaimmunomodulation |