Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents
Background: Carica papaya is a well known medicinal plant used in the West and Asian countries to cope several diseases. Patients were advised to eat papaya fruit frequently during dengue fever epidemic in Pakistan by physicians. This study was conducted to establish Polyphenols, flavonoids and anti...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2016
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/47518/1/47518.pdf |
| _version_ | 1825929818086047744 |
|---|---|
| author | Asghar, Nazia Naqvi, Syed Ali Raza Hussain, Zaib Rasool, Nasir Khan, Zulfiqar Ali Shahzad, Sohail Anjum Sherazi, Tauqir A. Janjua, Muhammad Ramzan Saeed Ashraf Nagra, Saeed Ahmad Zia-Ul-Haq, Muhammad Jaafar, Hawa Z. E. |
| author_facet | Asghar, Nazia Naqvi, Syed Ali Raza Hussain, Zaib Rasool, Nasir Khan, Zulfiqar Ali Shahzad, Sohail Anjum Sherazi, Tauqir A. Janjua, Muhammad Ramzan Saeed Ashraf Nagra, Saeed Ahmad Zia-Ul-Haq, Muhammad Jaafar, Hawa Z. E. |
| author_sort | Asghar, Nazia |
| collection | UPM |
| description | Background: Carica papaya is a well known medicinal plant used in the West and Asian countries to cope several diseases. Patients were advised to eat papaya fruit frequently during dengue fever epidemic in Pakistan by physicians. This study was conducted to establish Polyphenols, flavonoids and antioxidant potential profile of extracts of all major parts of the C. papaya with seven major solvents i.e. water, ethanol, methanol, n-butanol, dichloromethane, ethyl acetate, and n-hexane. Results: TPC, TFC, antioxidant and antibacterial potential were determined using different aqueous and organic solvents in addition to the determination of trace element in leaves, pulp and peel of C. papaya. Total soluble phenolics and flavonoids were found in promising quantity (≈66 mg GAE/g) especially in case of methanol and ethanol extracts. Antioxidant activity using DPPH free radical scavenging assay indicated leaves, bark, roots and pulp extracts showed >75.0 % scavenging potential while leaves and pulp showed 84.9 and 80.9 % inhibition of peroxidation, respectively. Reducing power assay showed leaves, pulp and roots extracts active to reduce Fe3+ to Fe2+ ions. The antibacterial study showed pulp extract is the best to cope infectious action of bacteria. Conclusion: This study was conducted to test the medicinal profile of all parts of C. papaya by extracting secondary metabolites with organic and aqueous solvents. Ethanol and methanol both were found to be the best solvents of choice to extract natural products to get maximum medicinal benefits and could be used to medicinal formulation against different infectious diseases. |
| first_indexed | 2024-03-06T09:02:16Z |
| format | Article |
| id | upm.eprints-47518 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:02:16Z |
| publishDate | 2016 |
| publisher | SpringerOpen |
| record_format | dspace |
| spelling | upm.eprints-475182016-05-20T02:57:48Z http://psasir.upm.edu.my/id/eprint/47518/ Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents Asghar, Nazia Naqvi, Syed Ali Raza Hussain, Zaib Rasool, Nasir Khan, Zulfiqar Ali Shahzad, Sohail Anjum Sherazi, Tauqir A. Janjua, Muhammad Ramzan Saeed Ashraf Nagra, Saeed Ahmad Zia-Ul-Haq, Muhammad Jaafar, Hawa Z. E. Background: Carica papaya is a well known medicinal plant used in the West and Asian countries to cope several diseases. Patients were advised to eat papaya fruit frequently during dengue fever epidemic in Pakistan by physicians. This study was conducted to establish Polyphenols, flavonoids and antioxidant potential profile of extracts of all major parts of the C. papaya with seven major solvents i.e. water, ethanol, methanol, n-butanol, dichloromethane, ethyl acetate, and n-hexane. Results: TPC, TFC, antioxidant and antibacterial potential were determined using different aqueous and organic solvents in addition to the determination of trace element in leaves, pulp and peel of C. papaya. Total soluble phenolics and flavonoids were found in promising quantity (≈66 mg GAE/g) especially in case of methanol and ethanol extracts. Antioxidant activity using DPPH free radical scavenging assay indicated leaves, bark, roots and pulp extracts showed >75.0 % scavenging potential while leaves and pulp showed 84.9 and 80.9 % inhibition of peroxidation, respectively. Reducing power assay showed leaves, pulp and roots extracts active to reduce Fe3+ to Fe2+ ions. The antibacterial study showed pulp extract is the best to cope infectious action of bacteria. Conclusion: This study was conducted to test the medicinal profile of all parts of C. papaya by extracting secondary metabolites with organic and aqueous solvents. Ethanol and methanol both were found to be the best solvents of choice to extract natural products to get maximum medicinal benefits and could be used to medicinal formulation against different infectious diseases. SpringerOpen 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/47518/1/47518.pdf Asghar, Nazia and Naqvi, Syed Ali Raza and Hussain, Zaib and Rasool, Nasir and Khan, Zulfiqar Ali and Shahzad, Sohail Anjum and Sherazi, Tauqir A. and Janjua, Muhammad Ramzan Saeed Ashraf and Nagra, Saeed Ahmad and Zia-Ul-Haq, Muhammad and Jaafar, Hawa Z. E. (2016) Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents. Chemistry Central Journal, 10 (1). art. no. 5. pp. 1-11. ISSN 1752-153X http://link.springer.com/article/10.1186/s13065-016-0149-0?view=classic 10.1186/s13065-016-0149-0 |
| spellingShingle | Asghar, Nazia Naqvi, Syed Ali Raza Hussain, Zaib Rasool, Nasir Khan, Zulfiqar Ali Shahzad, Sohail Anjum Sherazi, Tauqir A. Janjua, Muhammad Ramzan Saeed Ashraf Nagra, Saeed Ahmad Zia-Ul-Haq, Muhammad Jaafar, Hawa Z. E. Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents |
| title | Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents |
| title_full | Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents |
| title_fullStr | Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents |
| title_full_unstemmed | Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents |
| title_short | Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents |
| title_sort | compositional difference in antioxidant and antibacterial activity of all parts of the carica papaya using different solvents |
| url | http://psasir.upm.edu.my/id/eprint/47518/1/47518.pdf |
| work_keys_str_mv | AT asgharnazia compositionaldifferenceinantioxidantandantibacterialactivityofallpartsofthecaricapapayausingdifferentsolvents AT naqvisyedaliraza compositionaldifferenceinantioxidantandantibacterialactivityofallpartsofthecaricapapayausingdifferentsolvents AT hussainzaib compositionaldifferenceinantioxidantandantibacterialactivityofallpartsofthecaricapapayausingdifferentsolvents AT rasoolnasir compositionaldifferenceinantioxidantandantibacterialactivityofallpartsofthecaricapapayausingdifferentsolvents AT khanzulfiqarali compositionaldifferenceinantioxidantandantibacterialactivityofallpartsofthecaricapapayausingdifferentsolvents AT shahzadsohailanjum compositionaldifferenceinantioxidantandantibacterialactivityofallpartsofthecaricapapayausingdifferentsolvents AT sherazitauqira compositionaldifferenceinantioxidantandantibacterialactivityofallpartsofthecaricapapayausingdifferentsolvents AT janjuamuhammadramzansaeedashraf compositionaldifferenceinantioxidantandantibacterialactivityofallpartsofthecaricapapayausingdifferentsolvents AT nagrasaeedahmad compositionaldifferenceinantioxidantandantibacterialactivityofallpartsofthecaricapapayausingdifferentsolvents AT ziaulhaqmuhammad compositionaldifferenceinantioxidantandantibacterialactivityofallpartsofthecaricapapayausingdifferentsolvents AT jaafarhawaze compositionaldifferenceinantioxidantandantibacterialactivityofallpartsofthecaricapapayausingdifferentsolvents |