Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals
The present study was carried out to establish the antinociceptive and anti-inflammatory properties of Dicranopteris linearis leaves chloroform extract in experimental animals. The antinociceptive activity was measured using the abdominal constriction, formalin and hot plate tests, while the anti-in...
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| Format: | Article |
| Language: | English |
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The Pharmaceutical Society of Japan
2006
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| Online Access: | http://psasir.upm.edu.my/id/eprint/48556/1/Antinociceptive%20and%20anti-inflammatory%20activities%20of%20Dicranopteris%20linearis%20leaves%20chloroform%20extract%20in%20experimental%20animals.pdf |
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| author | Zakaria, Zainul Amiruddin Abdul Ghani, Zuleen Delina Fasya Raden Mohd Nor, Raden Nur Suraya Gopalan, Hanan Kumar Sulaiman, Mohd Roslan Abdullah, Fatimah Corazon |
| author_facet | Zakaria, Zainul Amiruddin Abdul Ghani, Zuleen Delina Fasya Raden Mohd Nor, Raden Nur Suraya Gopalan, Hanan Kumar Sulaiman, Mohd Roslan Abdullah, Fatimah Corazon |
| author_sort | Zakaria, Zainul Amiruddin |
| collection | UPM |
| description | The present study was carried out to establish the antinociceptive and anti-inflammatory properties of Dicranopteris linearis leaves chloroform extract in experimental animals. The antinociceptive activity was measured using the abdominal constriction, formalin and hot plate tests, while the anti-inflammatory activity was measured using the carrageenan-induced paw edema. The extract, obtained after 72 h soaking of the air-dried leaves in chloroform followed by evaporation under vacuo (40°C) to dryness, was dissolved in dimethyl sulfoxide to the doses of 20, 100 and 200 mg/kg and administered subcutaneously 30 min prior to subjection to the above mentioned assays. The extract, at all doses used, was found to exhibit significant (p<0.05) antinociceptive activity in a dose-dependent manner. However, the significant (p<0.05) anti-inflammatory activity observed occur in a dose-independent manner. As a conclusion, the chloroform extract of D. linearis possesses antinociceptive and anti-inflammatory activity and thus justify its traditional uses by the Malays to treat various ailments. |
| first_indexed | 2024-03-06T09:05:24Z |
| format | Article |
| id | upm.eprints-48556 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:05:24Z |
| publishDate | 2006 |
| publisher | The Pharmaceutical Society of Japan |
| record_format | dspace |
| spelling | upm.eprints-485562016-10-10T03:36:28Z http://psasir.upm.edu.my/id/eprint/48556/ Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals Zakaria, Zainul Amiruddin Abdul Ghani, Zuleen Delina Fasya Raden Mohd Nor, Raden Nur Suraya Gopalan, Hanan Kumar Sulaiman, Mohd Roslan Abdullah, Fatimah Corazon The present study was carried out to establish the antinociceptive and anti-inflammatory properties of Dicranopteris linearis leaves chloroform extract in experimental animals. The antinociceptive activity was measured using the abdominal constriction, formalin and hot plate tests, while the anti-inflammatory activity was measured using the carrageenan-induced paw edema. The extract, obtained after 72 h soaking of the air-dried leaves in chloroform followed by evaporation under vacuo (40°C) to dryness, was dissolved in dimethyl sulfoxide to the doses of 20, 100 and 200 mg/kg and administered subcutaneously 30 min prior to subjection to the above mentioned assays. The extract, at all doses used, was found to exhibit significant (p<0.05) antinociceptive activity in a dose-dependent manner. However, the significant (p<0.05) anti-inflammatory activity observed occur in a dose-independent manner. As a conclusion, the chloroform extract of D. linearis possesses antinociceptive and anti-inflammatory activity and thus justify its traditional uses by the Malays to treat various ailments. The Pharmaceutical Society of Japan 2006 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/48556/1/Antinociceptive%20and%20anti-inflammatory%20activities%20of%20Dicranopteris%20linearis%20leaves%20chloroform%20extract%20in%20experimental%20animals.pdf Zakaria, Zainul Amiruddin and Abdul Ghani, Zuleen Delina Fasya and Raden Mohd Nor, Raden Nur Suraya and Gopalan, Hanan Kumar and Sulaiman, Mohd Roslan and Abdullah, Fatimah Corazon (2006) Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals. Yakugaku Zasshi, 126 (11). pp. 1197-1203. ISSN 0031-6903; ESSN: 1347-5231 https://www.jstage.jst.go.jp/article/yakushi/126/11/126_11_1197/_article 10.1248/yakushi.126.1197 |
| spellingShingle | Zakaria, Zainul Amiruddin Abdul Ghani, Zuleen Delina Fasya Raden Mohd Nor, Raden Nur Suraya Gopalan, Hanan Kumar Sulaiman, Mohd Roslan Abdullah, Fatimah Corazon Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals |
| title | Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals |
| title_full | Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals |
| title_fullStr | Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals |
| title_full_unstemmed | Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals |
| title_short | Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals |
| title_sort | antinociceptive and anti inflammatory activities of dicranopteris linearis leaves chloroform extract in experimental animals |
| url | http://psasir.upm.edu.my/id/eprint/48556/1/Antinociceptive%20and%20anti-inflammatory%20activities%20of%20Dicranopteris%20linearis%20leaves%20chloroform%20extract%20in%20experimental%20animals.pdf |
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