Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals
The present study was carried out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of the aqueous extract of Melastoma malabathricum leaves in experimental animals. The antinociceptive activity was measured using abdominal constriction, hot-plate, and formalin tests, w...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
NRC Research Press
2006
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/48579/1/Antinociceptive%2C%20anti-inflammatory%20and%20antipyretic%20properties%20of%20Melastoma%20malabathricum%20leaves%20aqueous%20extract%20in%20experimental%20animals.pdf |
| _version_ | 1796975023029747712 |
|---|---|
| author | Zakaria, Zainul Amiruddin Raden Mohd Nor, Raden Nur Suraya Gopalan, Hanan Kumar Abdul Ghani, Zuleen Delina Fasya Sulaiman, Mohd Roslan Ganeson, Rathna Devi Mat Jais, Abdul Manan Somchit, Muhammad Nazrul Abdullah, Fatimah Corazon |
| author_facet | Zakaria, Zainul Amiruddin Raden Mohd Nor, Raden Nur Suraya Gopalan, Hanan Kumar Abdul Ghani, Zuleen Delina Fasya Sulaiman, Mohd Roslan Ganeson, Rathna Devi Mat Jais, Abdul Manan Somchit, Muhammad Nazrul Abdullah, Fatimah Corazon |
| author_sort | Zakaria, Zainul Amiruddin |
| collection | UPM |
| description | The present study was carried out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of the aqueous extract of Melastoma malabathricum leaves in experimental animals. The antinociceptive activity was measured using abdominal constriction, hot-plate, and formalin tests, whereas the anti-inflammatory and antipyretic activities were measured using carrageenan-induced paw edema and brewer’s yeast-induced pyrexia tests, respectively. The extract, which was obtained after soaking the air-dried leaves in distilled water for 72 h and then preparing in concentrations of 10%, 50%, and 100% (v/v), was administered subcutaneously 30 min prior to subjection to the above mentioned assays. At all concentrations tested, the extract was found to exhibit significant (P < 0.05) antinociceptive, anti-inflammatory, and antipyretic activities in a concentration-independent manner. Our findings that the aqueous extract of M. malabathricum possesses antinociceptive, anti-inflammatory, and antipyretic activities supports previous claims on its traditional uses to treat various ailments. |
| first_indexed | 2024-03-06T09:05:28Z |
| format | Article |
| id | upm.eprints-48579 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:05:28Z |
| publishDate | 2006 |
| publisher | NRC Research Press |
| record_format | dspace |
| spelling | upm.eprints-485792020-07-23T00:55:38Z http://psasir.upm.edu.my/id/eprint/48579/ Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals Zakaria, Zainul Amiruddin Raden Mohd Nor, Raden Nur Suraya Gopalan, Hanan Kumar Abdul Ghani, Zuleen Delina Fasya Sulaiman, Mohd Roslan Ganeson, Rathna Devi Mat Jais, Abdul Manan Somchit, Muhammad Nazrul Abdullah, Fatimah Corazon The present study was carried out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of the aqueous extract of Melastoma malabathricum leaves in experimental animals. The antinociceptive activity was measured using abdominal constriction, hot-plate, and formalin tests, whereas the anti-inflammatory and antipyretic activities were measured using carrageenan-induced paw edema and brewer’s yeast-induced pyrexia tests, respectively. The extract, which was obtained after soaking the air-dried leaves in distilled water for 72 h and then preparing in concentrations of 10%, 50%, and 100% (v/v), was administered subcutaneously 30 min prior to subjection to the above mentioned assays. At all concentrations tested, the extract was found to exhibit significant (P < 0.05) antinociceptive, anti-inflammatory, and antipyretic activities in a concentration-independent manner. Our findings that the aqueous extract of M. malabathricum possesses antinociceptive, anti-inflammatory, and antipyretic activities supports previous claims on its traditional uses to treat various ailments. NRC Research Press 2006 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/48579/1/Antinociceptive%2C%20anti-inflammatory%20and%20antipyretic%20properties%20of%20Melastoma%20malabathricum%20leaves%20aqueous%20extract%20in%20experimental%20animals.pdf Zakaria, Zainul Amiruddin and Raden Mohd Nor, Raden Nur Suraya and Gopalan, Hanan Kumar and Abdul Ghani, Zuleen Delina Fasya and Sulaiman, Mohd Roslan and Ganeson, Rathna Devi and Mat Jais, Abdul Manan and Somchit, Muhammad Nazrul and Abdullah, Fatimah Corazon (2006) Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals. Canadian Journal of Physiology and Pharmacology, 84 (12). pp. 1291-1299. ISSN 0008-4212; ESSN: 1205-7541 http://www.nrcresearchpress.com/doi/abs/10.1139/y06-083?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&#.V8eUnTVrsZM 10.1139/y06-083 |
| spellingShingle | Zakaria, Zainul Amiruddin Raden Mohd Nor, Raden Nur Suraya Gopalan, Hanan Kumar Abdul Ghani, Zuleen Delina Fasya Sulaiman, Mohd Roslan Ganeson, Rathna Devi Mat Jais, Abdul Manan Somchit, Muhammad Nazrul Abdullah, Fatimah Corazon Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals |
| title | Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals |
| title_full | Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals |
| title_fullStr | Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals |
| title_full_unstemmed | Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals |
| title_short | Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals |
| title_sort | antinociceptive anti inflammatory and antipyretic properties of melastoma malabathricum leaves aqueous extract in experimental animals |
| url | http://psasir.upm.edu.my/id/eprint/48579/1/Antinociceptive%2C%20anti-inflammatory%20and%20antipyretic%20properties%20of%20Melastoma%20malabathricum%20leaves%20aqueous%20extract%20in%20experimental%20animals.pdf |
| work_keys_str_mv | AT zakariazainulamiruddin antinociceptiveantiinflammatoryandantipyreticpropertiesofmelastomamalabathricumleavesaqueousextractinexperimentalanimals AT radenmohdnorradennursuraya antinociceptiveantiinflammatoryandantipyreticpropertiesofmelastomamalabathricumleavesaqueousextractinexperimentalanimals AT gopalanhanankumar antinociceptiveantiinflammatoryandantipyreticpropertiesofmelastomamalabathricumleavesaqueousextractinexperimentalanimals AT abdulghanizuleendelinafasya antinociceptiveantiinflammatoryandantipyreticpropertiesofmelastomamalabathricumleavesaqueousextractinexperimentalanimals AT sulaimanmohdroslan antinociceptiveantiinflammatoryandantipyreticpropertiesofmelastomamalabathricumleavesaqueousextractinexperimentalanimals AT ganesonrathnadevi antinociceptiveantiinflammatoryandantipyreticpropertiesofmelastomamalabathricumleavesaqueousextractinexperimentalanimals AT matjaisabdulmanan antinociceptiveantiinflammatoryandantipyreticpropertiesofmelastomamalabathricumleavesaqueousextractinexperimentalanimals AT somchitmuhammadnazrul antinociceptiveantiinflammatoryandantipyreticpropertiesofmelastomamalabathricumleavesaqueousextractinexperimentalanimals AT abdullahfatimahcorazon antinociceptiveantiinflammatoryandantipyreticpropertiesofmelastomamalabathricumleavesaqueousextractinexperimentalanimals |