Vitamin C and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat
The effects of vitamin C and aloe vera gel extract supplementation on induced hepatocarcinogenesis in male Sprague-Dawley rats (120–150 g) by diethylnitrosamine (DEN) and 2-acetylaminofluorene (AAF) was investigated. The severity of the carcinogenesis process was determined by measuring γ-glutamyl t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Elsevier Science
1998
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| Online Access: | http://psasir.upm.edu.my/id/eprint/51343/1/51343.pdf http://psasir.upm.edu.my/id/eprint/51343/7/1-s2.0-S0899900798001075-main.pdf |
| _version_ | 1811137480698626048 |
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| author | Shamaan, Nor Aripin Abdul Kadir, Khalid Rahmat, Asmah Wan Ngah, Wan Zurinah |
| author_facet | Shamaan, Nor Aripin Abdul Kadir, Khalid Rahmat, Asmah Wan Ngah, Wan Zurinah |
| author_sort | Shamaan, Nor Aripin |
| collection | UPM |
| description | The effects of vitamin C and aloe vera gel extract supplementation on induced hepatocarcinogenesis in male Sprague-Dawley rats (120–150 g) by diethylnitrosamine (DEN) and 2-acetylaminofluorene (AAF) was investigated. The severity of the carcinogenesis process was determined by measuring γ-glutamyl transpeptidase (GGT) and the placental form of glutathione S-transferase (GSTP) histochemically in situ and in plasma and liver fractions. In addition, plasma alkaline phosphatase (ALP) and liver microsomal uridine diphosphate glucuronyl transferase (UDPGT) activity were also determined. Administration of DEN/AAF caused an increase in the surface area and number of enzyme-positive foci (both GGT and GSTP) compared with control. Supplementation of vitamin C or aloe vera gel extract to the cancer-induced rats suppressed this increase significantly (P < 0.05; P < 0.001). Increases in liver UDPGT, GGT, and GSTP activities were also observed with cancer induction that were again suppressed with either vitamin C or aloe vera gel supplementation. Plasma GGT in the DEN/AAF rats were determined monthly for the duration of the experiment and found to be reduced as early as 1 mo with aloe vera gel supplementation and 2 mo with vitamin C supplementation. In conclusion, vitamin C and aloe vera gel extract supplementation were found to be able to reduce the severity of chemical hepatocarcinogenesis. |
| first_indexed | 2024-03-06T09:12:39Z |
| format | Article |
| id | upm.eprints-51343 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-09-25T03:34:58Z |
| publishDate | 1998 |
| publisher | Elsevier Science |
| record_format | dspace |
| spelling | upm.eprints-513432024-08-05T08:26:35Z http://psasir.upm.edu.my/id/eprint/51343/ Vitamin C and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat Shamaan, Nor Aripin Abdul Kadir, Khalid Rahmat, Asmah Wan Ngah, Wan Zurinah The effects of vitamin C and aloe vera gel extract supplementation on induced hepatocarcinogenesis in male Sprague-Dawley rats (120–150 g) by diethylnitrosamine (DEN) and 2-acetylaminofluorene (AAF) was investigated. The severity of the carcinogenesis process was determined by measuring γ-glutamyl transpeptidase (GGT) and the placental form of glutathione S-transferase (GSTP) histochemically in situ and in plasma and liver fractions. In addition, plasma alkaline phosphatase (ALP) and liver microsomal uridine diphosphate glucuronyl transferase (UDPGT) activity were also determined. Administration of DEN/AAF caused an increase in the surface area and number of enzyme-positive foci (both GGT and GSTP) compared with control. Supplementation of vitamin C or aloe vera gel extract to the cancer-induced rats suppressed this increase significantly (P < 0.05; P < 0.001). Increases in liver UDPGT, GGT, and GSTP activities were also observed with cancer induction that were again suppressed with either vitamin C or aloe vera gel supplementation. Plasma GGT in the DEN/AAF rats were determined monthly for the duration of the experiment and found to be reduced as early as 1 mo with aloe vera gel supplementation and 2 mo with vitamin C supplementation. In conclusion, vitamin C and aloe vera gel extract supplementation were found to be able to reduce the severity of chemical hepatocarcinogenesis. Elsevier Science 1998 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/51343/1/51343.pdf text en http://psasir.upm.edu.my/id/eprint/51343/7/1-s2.0-S0899900798001075-main.pdf Shamaan, Nor Aripin and Abdul Kadir, Khalid and Rahmat, Asmah and Wan Ngah, Wan Zurinah (1998) Vitamin C and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat. Nutrition, 14 (11/12). pp. 846-852. ISSN 0899-9007; ESSN: 1873-1244 http://www.sciencedirect.com/science/article/pii/S0899900798001075 10.1016/S0899-9007(98)00107-5 |
| spellingShingle | Shamaan, Nor Aripin Abdul Kadir, Khalid Rahmat, Asmah Wan Ngah, Wan Zurinah Vitamin C and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat |
| title | Vitamin C and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat |
| title_full | Vitamin C and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat |
| title_fullStr | Vitamin C and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat |
| title_full_unstemmed | Vitamin C and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat |
| title_short | Vitamin C and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat |
| title_sort | vitamin c and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat |
| url | http://psasir.upm.edu.my/id/eprint/51343/1/51343.pdf http://psasir.upm.edu.my/id/eprint/51343/7/1-s2.0-S0899900798001075-main.pdf |
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