Effect of dehydration on the pharmacokinetics of oxytetracycline hydrochloride administered intravenously in goats (Capra hircus)
1. The effects of various levels of dehydration induced by water deprivation were studied in six Nubian goats on the pharmacokinetics of oxytetracycline after intravenous administration (5 mg/kg). 2. In goats that had lost an average of 7.6% body weight after 2 days of water deprivation, the elimi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Elsevier Science
1998
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| Online Access: | http://psasir.upm.edu.my/id/eprint/51658/1/51658.pdf http://psasir.upm.edu.my/id/eprint/51658/7/1-s2.0-S0306362398000135-main.pdf |
| _version_ | 1811137483096719360 |
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| author | Elsheikh, Hatim Ali Intisar, A. M. Osman Eltayeb, Idris Babiker Abdullah, Abdul Salam |
| author_facet | Elsheikh, Hatim Ali Intisar, A. M. Osman Eltayeb, Idris Babiker Abdullah, Abdul Salam |
| author_sort | Elsheikh, Hatim Ali |
| collection | UPM |
| description | 1. The effects of various levels of dehydration induced by water deprivation were studied in six Nubian goats on the pharmacokinetics of oxytetracycline after intravenous administration (5 mg/kg).
2. In goats that had lost an average of 7.6% body weight after 2 days of water deprivation, the elimination rate constant of the drug was significantly decreased (P<0.01) and the total body clearance was significantly slower (P<0.001). No statistically significant changes were observed in the pharmacokinetic parameters describing the distribution of the drug at this dehydration level.
3. Water deprivation for 3 or 4 days resulted in a level of dehydration at which the goats lost an average of 10.3% or 12.7% of their body weight, respectively; significant changes were observed in the pharmacokinetic distribution and elimination parameters of oxytetracycline. The volume of distribution at steady state was significantly decreased (P<0.01). Significantly slower total body clearance (P<0.001) and subsequent prolongation of the elimination half-life were found at these dehydration levels.
4. The alterations caused by dehydration on the disposition kinetics of the drug should be considered for better definition of dosage regimens for sick, dehydrated animals. |
| first_indexed | 2024-03-06T09:13:34Z |
| format | Article |
| id | upm.eprints-51658 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-09-25T03:35:01Z |
| publishDate | 1998 |
| publisher | Elsevier Science |
| record_format | dspace |
| spelling | upm.eprints-516582024-08-08T00:08:46Z http://psasir.upm.edu.my/id/eprint/51658/ Effect of dehydration on the pharmacokinetics of oxytetracycline hydrochloride administered intravenously in goats (Capra hircus) Elsheikh, Hatim Ali Intisar, A. M. Osman Eltayeb, Idris Babiker Abdullah, Abdul Salam 1. The effects of various levels of dehydration induced by water deprivation were studied in six Nubian goats on the pharmacokinetics of oxytetracycline after intravenous administration (5 mg/kg). 2. In goats that had lost an average of 7.6% body weight after 2 days of water deprivation, the elimination rate constant of the drug was significantly decreased (P<0.01) and the total body clearance was significantly slower (P<0.001). No statistically significant changes were observed in the pharmacokinetic parameters describing the distribution of the drug at this dehydration level. 3. Water deprivation for 3 or 4 days resulted in a level of dehydration at which the goats lost an average of 10.3% or 12.7% of their body weight, respectively; significant changes were observed in the pharmacokinetic distribution and elimination parameters of oxytetracycline. The volume of distribution at steady state was significantly decreased (P<0.01). Significantly slower total body clearance (P<0.001) and subsequent prolongation of the elimination half-life were found at these dehydration levels. 4. The alterations caused by dehydration on the disposition kinetics of the drug should be considered for better definition of dosage regimens for sick, dehydrated animals. Elsevier Science 1998 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/51658/1/51658.pdf text en http://psasir.upm.edu.my/id/eprint/51658/7/1-s2.0-S0306362398000135-main.pdf Elsheikh, Hatim Ali and Intisar, A. M. Osman and Eltayeb, Idris Babiker and Abdullah, Abdul Salam (1998) Effect of dehydration on the pharmacokinetics of oxytetracycline hydrochloride administered intravenously in goats (Capra hircus). General Pharmacology: the Vascular System, 31 (3). pp. 455-458. ISSN 0306-3623 http://www.sciencedirect.com/science/article/pii/S0306362398000135 10.1016/S0306-3623(98)00013-5 |
| spellingShingle | Elsheikh, Hatim Ali Intisar, A. M. Osman Eltayeb, Idris Babiker Abdullah, Abdul Salam Effect of dehydration on the pharmacokinetics of oxytetracycline hydrochloride administered intravenously in goats (Capra hircus) |
| title | Effect of dehydration on the pharmacokinetics of oxytetracycline hydrochloride administered intravenously in goats (Capra hircus) |
| title_full | Effect of dehydration on the pharmacokinetics of oxytetracycline hydrochloride administered intravenously in goats (Capra hircus) |
| title_fullStr | Effect of dehydration on the pharmacokinetics of oxytetracycline hydrochloride administered intravenously in goats (Capra hircus) |
| title_full_unstemmed | Effect of dehydration on the pharmacokinetics of oxytetracycline hydrochloride administered intravenously in goats (Capra hircus) |
| title_short | Effect of dehydration on the pharmacokinetics of oxytetracycline hydrochloride administered intravenously in goats (Capra hircus) |
| title_sort | effect of dehydration on the pharmacokinetics of oxytetracycline hydrochloride administered intravenously in goats capra hircus |
| url | http://psasir.upm.edu.my/id/eprint/51658/1/51658.pdf http://psasir.upm.edu.my/id/eprint/51658/7/1-s2.0-S0306362398000135-main.pdf |
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