Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome
Introduction: Metabolic syndrome is associated with low-grade, chronic inflammation. Our study aimed to evaluate the effects of tocotrienols supplementation on cytokines and lipid profile in adults with metabolic syndrome. Methods: In a 16-week randomised, double-blind, placebo-controlled trial, 70...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nutrition Society of Malaysia
2015
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/51979/1/Potential%20of%20mixed%20tocotrienol%20supplementation%20to%20reduce%20cholesterol%20and%20cytokines%20level%20in%20adults%20with%20metabolic%20syndrome.pdf |
| _version_ | 1825930635290607616 |
|---|---|
| author | Heng, Kiang Soon Abdul Rahman, Hejar Stanslas, Johnson Ooi, Cheow Peng Loh, Su Peng |
| author_facet | Heng, Kiang Soon Abdul Rahman, Hejar Stanslas, Johnson Ooi, Cheow Peng Loh, Su Peng |
| author_sort | Heng, Kiang Soon |
| collection | UPM |
| description | Introduction: Metabolic syndrome is associated with low-grade, chronic inflammation. Our study aimed to evaluate the effects of tocotrienols supplementation on cytokines and lipid profile in adults with metabolic syndrome. Methods: In a 16-week randomised, double-blind, placebo-controlled trial, 70 adults with metabolic syndrome aged 20-60 years were randomly assigned to a mixed tocotrienols group (n=35) that received 400mg/day of mixed tocotrienols or a placebo group (n=35) that received capsules containing soy bean oil. At baseline, week 8 and week 16, anthropometric, body composition and blood pressure measurements were conducted. At baseline and week 16 only, serum levels of total cholesterol (TC) and high density lipoprotein (HDL)-cholesterol, plasma levels of fasting plasma glucose (FPG), interleukin-6 (IL-6), tumouxr necrosis factor- a (TNF-a), leptin, adiponectin and high sensitivity C-reactive protein were also determined. Changes in dietary intake and physical activity level between baseline, week 8 and week 16 were also assessed. Results: In the tocotrienols group, significant reductions from baseline were found in diastolic blood pressure (p=0.001), TC (p=0.008), LDL-cholesterol (p=0.022), HDL-cholesterol (p<0.001), IL-6 (p=0.024) and TNF-a (p=0.013) at week sixteen. However, the changes in the tocotrienols group were not significantly different from those of the placebo group. Conclusion: The 16-week mixed tocotrienols supplementation exerted potential beneficial effects on cytokines and lipid profile in adults with metabolic syndrome. The results might have been confounded by the physiological effects produced by the soy bean oil in the placebo capsule. |
| first_indexed | 2024-03-06T09:14:33Z |
| format | Article |
| id | upm.eprints-51979 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:14:33Z |
| publishDate | 2015 |
| publisher | Nutrition Society of Malaysia |
| record_format | dspace |
| spelling | upm.eprints-519792017-05-04T04:44:28Z http://psasir.upm.edu.my/id/eprint/51979/ Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome Heng, Kiang Soon Abdul Rahman, Hejar Stanslas, Johnson Ooi, Cheow Peng Loh, Su Peng Introduction: Metabolic syndrome is associated with low-grade, chronic inflammation. Our study aimed to evaluate the effects of tocotrienols supplementation on cytokines and lipid profile in adults with metabolic syndrome. Methods: In a 16-week randomised, double-blind, placebo-controlled trial, 70 adults with metabolic syndrome aged 20-60 years were randomly assigned to a mixed tocotrienols group (n=35) that received 400mg/day of mixed tocotrienols or a placebo group (n=35) that received capsules containing soy bean oil. At baseline, week 8 and week 16, anthropometric, body composition and blood pressure measurements were conducted. At baseline and week 16 only, serum levels of total cholesterol (TC) and high density lipoprotein (HDL)-cholesterol, plasma levels of fasting plasma glucose (FPG), interleukin-6 (IL-6), tumouxr necrosis factor- a (TNF-a), leptin, adiponectin and high sensitivity C-reactive protein were also determined. Changes in dietary intake and physical activity level between baseline, week 8 and week 16 were also assessed. Results: In the tocotrienols group, significant reductions from baseline were found in diastolic blood pressure (p=0.001), TC (p=0.008), LDL-cholesterol (p=0.022), HDL-cholesterol (p<0.001), IL-6 (p=0.024) and TNF-a (p=0.013) at week sixteen. However, the changes in the tocotrienols group were not significantly different from those of the placebo group. Conclusion: The 16-week mixed tocotrienols supplementation exerted potential beneficial effects on cytokines and lipid profile in adults with metabolic syndrome. The results might have been confounded by the physiological effects produced by the soy bean oil in the placebo capsule. Nutrition Society of Malaysia 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/51979/1/Potential%20of%20mixed%20tocotrienol%20supplementation%20to%20reduce%20cholesterol%20and%20cytokines%20level%20in%20adults%20with%20metabolic%20syndrome.pdf Heng, Kiang Soon and Abdul Rahman, Hejar and Stanslas, Johnson and Ooi, Cheow Peng and Loh, Su Peng (2015) Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome. Malaysian Journal of Nutrition, 21 (2). pp. 231-243. ISSN 1394-035X http://www.nutriweb.org.my/publications/mjn0021_2/9-%20Loh%20SP%20231-244.php |
| spellingShingle | Heng, Kiang Soon Abdul Rahman, Hejar Stanslas, Johnson Ooi, Cheow Peng Loh, Su Peng Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome |
| title | Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome |
| title_full | Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome |
| title_fullStr | Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome |
| title_full_unstemmed | Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome |
| title_short | Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome |
| title_sort | potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome |
| url | http://psasir.upm.edu.my/id/eprint/51979/1/Potential%20of%20mixed%20tocotrienol%20supplementation%20to%20reduce%20cholesterol%20and%20cytokines%20level%20in%20adults%20with%20metabolic%20syndrome.pdf |
| work_keys_str_mv | AT hengkiangsoon potentialofmixedtocotrienolsupplementationtoreducecholesterolandcytokineslevelinadultswithmetabolicsyndrome AT abdulrahmanhejar potentialofmixedtocotrienolsupplementationtoreducecholesterolandcytokineslevelinadultswithmetabolicsyndrome AT stanslasjohnson potentialofmixedtocotrienolsupplementationtoreducecholesterolandcytokineslevelinadultswithmetabolicsyndrome AT ooicheowpeng potentialofmixedtocotrienolsupplementationtoreducecholesterolandcytokineslevelinadultswithmetabolicsyndrome AT lohsupeng potentialofmixedtocotrienolsupplementationtoreducecholesterolandcytokineslevelinadultswithmetabolicsyndrome |