Antinociceptive effect of 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in mice models of induced nociception
The antinociceptive effects produced by intraperitoneal administration of a novel synthetic chalcone, 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one (DMFP), were investigated in several mouse models of induced nociception. The administration of DMFP (0.1, 0.5, 1.0 and 5.0 mg/kg) produ...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/52006/1/52006.pdf |
| _version_ | 1825930640716988416 |
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| author | Ismail, Nur Izzati Lee, Ming Tatt Lajis, Md. Nordin Akhtar, Muhammad Nadeem Omar Farouk, Ahmad Akira Perimal, Enoch Kumar Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan |
| author_facet | Ismail, Nur Izzati Lee, Ming Tatt Lajis, Md. Nordin Akhtar, Muhammad Nadeem Omar Farouk, Ahmad Akira Perimal, Enoch Kumar Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan |
| author_sort | Ismail, Nur Izzati |
| collection | UPM |
| description | The antinociceptive effects produced by intraperitoneal administration of a novel synthetic chalcone, 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one (DMFP), were investigated in several mouse models of induced nociception. The administration of DMFP (0.1, 0.5, 1.0 and 5.0 mg/kg) produced significant attenuation on the acetic acid-induced abdominal-writhing test. It also produced a significant increase in response latency time in the hot-plate test and a marked reduction in time spent licking the injected paw in both phases of the formalin-induced paw-licking test. In addition, it was also demonstrated that DMFP exhibited significant inhibition of the neurogenic nociceptive response induced by intraplantar injections of capsaicin and glutamate. Moreover, the antinociceptive effect of DMFP in the acetic acid-induced abdominal-writhing test and the hot-plate test was not antagonized by pretreatment with a non-selective opioid receptor antagonist, naloxone. Finally, DMFP did not show any toxic effects and/or mortality in a study of acute toxicity and did not interfere with motor coordination during the Rota-rod test. Our present results show that DMFP exhibits both peripheral and central antinociceptive effects. It was suggested that its peripheral antinociceptive activity is associated with attenuated production and/or release of NO and various pro-inflammatory mediators, while central antinociceptive activity seems to be unrelated to the opioidergic system, but could involve, at least in part, an interaction with the inhibition of capsaicin-sensitive fibers and the glutamatergic system. |
| first_indexed | 2024-03-06T09:14:38Z |
| format | Article |
| id | upm.eprints-52006 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:14:38Z |
| publishDate | 2016 |
| publisher | MDPI |
| record_format | dspace |
| spelling | upm.eprints-520062017-05-04T08:40:49Z http://psasir.upm.edu.my/id/eprint/52006/ Antinociceptive effect of 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in mice models of induced nociception Ismail, Nur Izzati Lee, Ming Tatt Lajis, Md. Nordin Akhtar, Muhammad Nadeem Omar Farouk, Ahmad Akira Perimal, Enoch Kumar Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan The antinociceptive effects produced by intraperitoneal administration of a novel synthetic chalcone, 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one (DMFP), were investigated in several mouse models of induced nociception. The administration of DMFP (0.1, 0.5, 1.0 and 5.0 mg/kg) produced significant attenuation on the acetic acid-induced abdominal-writhing test. It also produced a significant increase in response latency time in the hot-plate test and a marked reduction in time spent licking the injected paw in both phases of the formalin-induced paw-licking test. In addition, it was also demonstrated that DMFP exhibited significant inhibition of the neurogenic nociceptive response induced by intraplantar injections of capsaicin and glutamate. Moreover, the antinociceptive effect of DMFP in the acetic acid-induced abdominal-writhing test and the hot-plate test was not antagonized by pretreatment with a non-selective opioid receptor antagonist, naloxone. Finally, DMFP did not show any toxic effects and/or mortality in a study of acute toxicity and did not interfere with motor coordination during the Rota-rod test. Our present results show that DMFP exhibits both peripheral and central antinociceptive effects. It was suggested that its peripheral antinociceptive activity is associated with attenuated production and/or release of NO and various pro-inflammatory mediators, while central antinociceptive activity seems to be unrelated to the opioidergic system, but could involve, at least in part, an interaction with the inhibition of capsaicin-sensitive fibers and the glutamatergic system. MDPI 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/52006/1/52006.pdf Ismail, Nur Izzati and Lee, Ming Tatt and Lajis, Md. Nordin and Akhtar, Muhammad Nadeem and Omar Farouk, Ahmad Akira and Perimal, Enoch Kumar and Israf Ali, Daud Ahmad and Sulaiman, Mohd Roslan (2016) Antinociceptive effect of 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in mice models of induced nociception. Molecules, 21 (8). art. no. 1077. pp. 1-16. ISSN 1420-3049 http://www.mdpi.com/1420-3049/21/8/1077 10.3390/molecules21081077 |
| spellingShingle | Ismail, Nur Izzati Lee, Ming Tatt Lajis, Md. Nordin Akhtar, Muhammad Nadeem Omar Farouk, Ahmad Akira Perimal, Enoch Kumar Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan Antinociceptive effect of 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in mice models of induced nociception |
| title | Antinociceptive effect of 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in mice models of induced nociception |
| title_full | Antinociceptive effect of 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in mice models of induced nociception |
| title_fullStr | Antinociceptive effect of 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in mice models of induced nociception |
| title_full_unstemmed | Antinociceptive effect of 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in mice models of induced nociception |
| title_short | Antinociceptive effect of 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in mice models of induced nociception |
| title_sort | antinociceptive effect of 3 2 3 dimethoxyphenyl 1 5 methylfuran 2 yl prop 2 en 1 one in mice models of induced nociception |
| url | http://psasir.upm.edu.my/id/eprint/52006/1/52006.pdf |
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