Evaluation of antioxidant and cytotoxicity activities of copper ferrite (CuFe2O4) and zinc ferrite (ZnFe2O4) nanoparticles synthesized by sol-gel self-combustion method
Spinel copper ferrite (CuFe2O4) and zinc ferrite (ZnFe2O4) nanoparticles were synthesized using a sol-gel self-combustion technique. The structural, functional, morphological and magnetic properties of the samples were investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/52108/1/52108.pdf |
| _version_ | 1825930660827627520 |
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| author | Kanagesan, Samikannu Hashim, Mansor Ab. Aziz, Sidek Ismail, Ismayadi Subramani, Tamilselvan Mohammed Alitheen, Noorjahan Banu Swamy, Mallappa Kumara Rao, Bandaru Purna Chandra |
| author_facet | Kanagesan, Samikannu Hashim, Mansor Ab. Aziz, Sidek Ismail, Ismayadi Subramani, Tamilselvan Mohammed Alitheen, Noorjahan Banu Swamy, Mallappa Kumara Rao, Bandaru Purna Chandra |
| author_sort | Kanagesan, Samikannu |
| collection | UPM |
| description | Spinel copper ferrite (CuFe2O4) and zinc ferrite (ZnFe2O4) nanoparticles were synthesized using a sol-gel self-combustion technique. The structural, functional, morphological and magnetic properties of the samples were investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Transmission electron microscopy (TEM) and vibrating sample magnetometry (VSM). XRD patterns conform to the copper ferrite and zinc ferrite formation, and the average particle sizes were calculated by using a transmission electron microscope, the measured particle sizes being 56 nm for CuFe2O4 and 68 nm for ZnFe2O4. Both spinel ferrite nanoparticles exhibit ferromagnetic behavior with saturation magnetization of 31 emug-1 for copper ferrite (50.63Am2/Kg) and 28.8 Am2/Kg for zinc ferrite. Both synthesized ferrite nanoparticles were equally effective in scavenging 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) free radicals. ZnFe2O4 and CuFe2O4 nanoparticles showed 30.57% ± 1.0% and 28.69% ± 1.14% scavenging activity at 125 μg/mL concentrations. In vitro cytotoxicity study revealed higher concentrations (> 125 μg/mL) of ZnFe2O4 and CuFe2O4 with increased toxicity against MCF-7 cells, but were found to be non-toxic at lower concentrations suggesting their biocompatibility. |
| first_indexed | 2024-03-06T09:14:56Z |
| format | Article |
| id | upm.eprints-52108 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:14:56Z |
| publishDate | 2016 |
| publisher | MDPI |
| record_format | dspace |
| spelling | upm.eprints-521082017-05-05T02:58:20Z http://psasir.upm.edu.my/id/eprint/52108/ Evaluation of antioxidant and cytotoxicity activities of copper ferrite (CuFe2O4) and zinc ferrite (ZnFe2O4) nanoparticles synthesized by sol-gel self-combustion method Kanagesan, Samikannu Hashim, Mansor Ab. Aziz, Sidek Ismail, Ismayadi Subramani, Tamilselvan Mohammed Alitheen, Noorjahan Banu Swamy, Mallappa Kumara Rao, Bandaru Purna Chandra Spinel copper ferrite (CuFe2O4) and zinc ferrite (ZnFe2O4) nanoparticles were synthesized using a sol-gel self-combustion technique. The structural, functional, morphological and magnetic properties of the samples were investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Transmission electron microscopy (TEM) and vibrating sample magnetometry (VSM). XRD patterns conform to the copper ferrite and zinc ferrite formation, and the average particle sizes were calculated by using a transmission electron microscope, the measured particle sizes being 56 nm for CuFe2O4 and 68 nm for ZnFe2O4. Both spinel ferrite nanoparticles exhibit ferromagnetic behavior with saturation magnetization of 31 emug-1 for copper ferrite (50.63Am2/Kg) and 28.8 Am2/Kg for zinc ferrite. Both synthesized ferrite nanoparticles were equally effective in scavenging 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) free radicals. ZnFe2O4 and CuFe2O4 nanoparticles showed 30.57% ± 1.0% and 28.69% ± 1.14% scavenging activity at 125 μg/mL concentrations. In vitro cytotoxicity study revealed higher concentrations (> 125 μg/mL) of ZnFe2O4 and CuFe2O4 with increased toxicity against MCF-7 cells, but were found to be non-toxic at lower concentrations suggesting their biocompatibility. MDPI 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/52108/1/52108.pdf Kanagesan, Samikannu and Hashim, Mansor and Ab. Aziz, Sidek and Ismail, Ismayadi and Subramani, Tamilselvan and Mohammed Alitheen, Noorjahan Banu and Swamy, Mallappa Kumara and Rao, Bandaru Purna Chandra (2016) Evaluation of antioxidant and cytotoxicity activities of copper ferrite (CuFe2O4) and zinc ferrite (ZnFe2O4) nanoparticles synthesized by sol-gel self-combustion method. Applied Sciences, 6 (9). art. no. 184. pp. 1-13. ISSN 2076-3417 http://www.mdpi.com/2076-3417/6/9/184 10.3390/app6090184 |
| spellingShingle | Kanagesan, Samikannu Hashim, Mansor Ab. Aziz, Sidek Ismail, Ismayadi Subramani, Tamilselvan Mohammed Alitheen, Noorjahan Banu Swamy, Mallappa Kumara Rao, Bandaru Purna Chandra Evaluation of antioxidant and cytotoxicity activities of copper ferrite (CuFe2O4) and zinc ferrite (ZnFe2O4) nanoparticles synthesized by sol-gel self-combustion method |
| title | Evaluation of antioxidant and cytotoxicity activities of copper ferrite (CuFe2O4) and zinc ferrite (ZnFe2O4) nanoparticles synthesized by sol-gel self-combustion method |
| title_full | Evaluation of antioxidant and cytotoxicity activities of copper ferrite (CuFe2O4) and zinc ferrite (ZnFe2O4) nanoparticles synthesized by sol-gel self-combustion method |
| title_fullStr | Evaluation of antioxidant and cytotoxicity activities of copper ferrite (CuFe2O4) and zinc ferrite (ZnFe2O4) nanoparticles synthesized by sol-gel self-combustion method |
| title_full_unstemmed | Evaluation of antioxidant and cytotoxicity activities of copper ferrite (CuFe2O4) and zinc ferrite (ZnFe2O4) nanoparticles synthesized by sol-gel self-combustion method |
| title_short | Evaluation of antioxidant and cytotoxicity activities of copper ferrite (CuFe2O4) and zinc ferrite (ZnFe2O4) nanoparticles synthesized by sol-gel self-combustion method |
| title_sort | evaluation of antioxidant and cytotoxicity activities of copper ferrite cufe2o4 and zinc ferrite znfe2o4 nanoparticles synthesized by sol gel self combustion method |
| url | http://psasir.upm.edu.my/id/eprint/52108/1/52108.pdf |
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