Synthesis, characterization and in vitro evaluation of manganese ferrite (MnFe2O4) nanoparticles for their biocompatibility with murine breast cancer cells (4T1)
Manganese ferrite (MnFe2O4) magnetic nanoparticles were successfully prepared by a sol-gel self-combustion technique using iron nitrate and manganese nitrate, followed by calcination at 150 °C for 24 h. Calcined sample was systematically characterized by X-ray diffraction (XRD), Fourier transform in...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/52112/1/52112.pdf |
| _version_ | 1825930661627691008 |
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| author | Kanagesan, Samikannu Ab. Aziz, Sidek Hashim, Mansor Ismail, Ismayadi Subramani, Tamilselvan Mohammed Alitheen, Noorjahan Banu Swamy, Mallappa Kumara Rao, Bandaru Purna Chandra |
| author_facet | Kanagesan, Samikannu Ab. Aziz, Sidek Hashim, Mansor Ismail, Ismayadi Subramani, Tamilselvan Mohammed Alitheen, Noorjahan Banu Swamy, Mallappa Kumara Rao, Bandaru Purna Chandra |
| author_sort | Kanagesan, Samikannu |
| collection | UPM |
| description | Manganese ferrite (MnFe2O4) magnetic nanoparticles were successfully prepared by a sol-gel self-combustion technique using iron nitrate and manganese nitrate, followed by calcination at 150 °C for 24 h. Calcined sample was systematically characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and vibrational sample magnetometry (VSM) in order to identify the crystalline phase, functional group, morphology, particle size, shape and magnetic behavior. It was observed that the resultant spinal ferrites obtained at low temperature exhibit single phase, nanoparticle size and good magnetic behavior. The study results have revealed the existence of a potent dose dependent cytotoxic effect of MnFe2O4 nanoparticles against 4T1 cell lines at varying concentrations with IC50 values of 210, 198 and 171 μg/mL after 24 h, 48 h and 72 h of incubation, respectively. Cells exposed to higher concentrations of nanoparticles showed a progressive increase of apoptotic and necrotic activity. Below 125 μg/mL concentration the nanoparticles were biocompatible with 4T1 cells. |
| first_indexed | 2024-03-06T09:14:57Z |
| format | Article |
| id | upm.eprints-52112 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:14:57Z |
| publishDate | 2016 |
| publisher | MDPI |
| record_format | dspace |
| spelling | upm.eprints-521122017-05-05T02:58:15Z http://psasir.upm.edu.my/id/eprint/52112/ Synthesis, characterization and in vitro evaluation of manganese ferrite (MnFe2O4) nanoparticles for their biocompatibility with murine breast cancer cells (4T1) Kanagesan, Samikannu Ab. Aziz, Sidek Hashim, Mansor Ismail, Ismayadi Subramani, Tamilselvan Mohammed Alitheen, Noorjahan Banu Swamy, Mallappa Kumara Rao, Bandaru Purna Chandra Manganese ferrite (MnFe2O4) magnetic nanoparticles were successfully prepared by a sol-gel self-combustion technique using iron nitrate and manganese nitrate, followed by calcination at 150 °C for 24 h. Calcined sample was systematically characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and vibrational sample magnetometry (VSM) in order to identify the crystalline phase, functional group, morphology, particle size, shape and magnetic behavior. It was observed that the resultant spinal ferrites obtained at low temperature exhibit single phase, nanoparticle size and good magnetic behavior. The study results have revealed the existence of a potent dose dependent cytotoxic effect of MnFe2O4 nanoparticles against 4T1 cell lines at varying concentrations with IC50 values of 210, 198 and 171 μg/mL after 24 h, 48 h and 72 h of incubation, respectively. Cells exposed to higher concentrations of nanoparticles showed a progressive increase of apoptotic and necrotic activity. Below 125 μg/mL concentration the nanoparticles were biocompatible with 4T1 cells. MDPI 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/52112/1/52112.pdf Kanagesan, Samikannu and Ab. Aziz, Sidek and Hashim, Mansor and Ismail, Ismayadi and Subramani, Tamilselvan and Mohammed Alitheen, Noorjahan Banu and Swamy, Mallappa Kumara and Rao, Bandaru Purna Chandra (2016) Synthesis, characterization and in vitro evaluation of manganese ferrite (MnFe2O4) nanoparticles for their biocompatibility with murine breast cancer cells (4T1). Molecules, 21 (3). art. no. 312. pp. 1-9. ISSN 1420-3049 http://www.mdpi.com/1420-3049/21/3/312 10.3390/molecules21030312 |
| spellingShingle | Kanagesan, Samikannu Ab. Aziz, Sidek Hashim, Mansor Ismail, Ismayadi Subramani, Tamilselvan Mohammed Alitheen, Noorjahan Banu Swamy, Mallappa Kumara Rao, Bandaru Purna Chandra Synthesis, characterization and in vitro evaluation of manganese ferrite (MnFe2O4) nanoparticles for their biocompatibility with murine breast cancer cells (4T1) |
| title | Synthesis, characterization and in vitro evaluation of manganese ferrite (MnFe2O4) nanoparticles for their biocompatibility with murine breast cancer cells (4T1) |
| title_full | Synthesis, characterization and in vitro evaluation of manganese ferrite (MnFe2O4) nanoparticles for their biocompatibility with murine breast cancer cells (4T1) |
| title_fullStr | Synthesis, characterization and in vitro evaluation of manganese ferrite (MnFe2O4) nanoparticles for their biocompatibility with murine breast cancer cells (4T1) |
| title_full_unstemmed | Synthesis, characterization and in vitro evaluation of manganese ferrite (MnFe2O4) nanoparticles for their biocompatibility with murine breast cancer cells (4T1) |
| title_short | Synthesis, characterization and in vitro evaluation of manganese ferrite (MnFe2O4) nanoparticles for their biocompatibility with murine breast cancer cells (4T1) |
| title_sort | synthesis characterization and in vitro evaluation of manganese ferrite mnfe2o4 nanoparticles for their biocompatibility with murine breast cancer cells 4t1 |
| url | http://psasir.upm.edu.my/id/eprint/52112/1/52112.pdf |
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