The rationale behind antibiotic resistance pattern in Klebsiella pneumoniae
Presently, there is an increase in antibiotic resistance in bacteria, due to relax prescription of antibiotics, especially in Iran. Undoubtedly, in toxin antitoxin (TA) system, a toxin neutralized by antitoxin, which known as a potent antimicrobial target; but there is no extensive survey on the pre...
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| Format: | Article |
| Language: | English |
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Malaysian Society of Parasitology and Tropical Medicine
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/53071/1/The%20rationale%20behind%20antibiotic%20resistance%20pattern%20in%20Klebsiella%20pneumonia.pdf |
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| author | Valian, F. Sadeghifard, N. Pakzad, I. Valizadeh, N. Karami, Shahriar Badakhsh, Badakhsh Sekawi, Zamberi Taherikalani, M. Valadbeigi, H. Ghafourian, Sobhan |
| author_facet | Valian, F. Sadeghifard, N. Pakzad, I. Valizadeh, N. Karami, Shahriar Badakhsh, Badakhsh Sekawi, Zamberi Taherikalani, M. Valadbeigi, H. Ghafourian, Sobhan |
| author_sort | Valian, F. |
| collection | UPM |
| description | Presently, there is an increase in antibiotic resistance in bacteria, due to relax prescription of antibiotics, especially in Iran. Undoubtedly, in toxin antitoxin (TA) system, a toxin neutralized by antitoxin, which known as a potent antimicrobial target; but there is no extensive survey on the prevalence of TA loci in large scale of Klebsiella pneumoniae. Therefore, this study aims to determine the prevalence of different TA loci in clinical and environmental K. pneumoniae isolates. For this reason, 48 K. pneumoniae clinical isolates and 49 K. pneumoniae environmental isolates were subjected for evaluation of different TA loci. The results of current study indicated that there is no association between antibiotic resistances and presence of TA loci in clinical and environmental K. pneumoniae. The role of TA loci as a potent target in antibiotic resistant K. pneumoniae has been complicated. Therefore, more studies should be performed to explain why TA loci are presented in K. pneumoniae and what is the rationale behind antibiotic resistant K. pneumoniae?. |
| first_indexed | 2024-03-06T09:17:02Z |
| format | Article |
| id | upm.eprints-53071 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:17:02Z |
| publishDate | 2016 |
| publisher | Malaysian Society of Parasitology and Tropical Medicine |
| record_format | dspace |
| spelling | upm.eprints-530712017-11-15T09:12:48Z http://psasir.upm.edu.my/id/eprint/53071/ The rationale behind antibiotic resistance pattern in Klebsiella pneumoniae Valian, F. Sadeghifard, N. Pakzad, I. Valizadeh, N. Karami, Shahriar Badakhsh, Badakhsh Sekawi, Zamberi Taherikalani, M. Valadbeigi, H. Ghafourian, Sobhan Presently, there is an increase in antibiotic resistance in bacteria, due to relax prescription of antibiotics, especially in Iran. Undoubtedly, in toxin antitoxin (TA) system, a toxin neutralized by antitoxin, which known as a potent antimicrobial target; but there is no extensive survey on the prevalence of TA loci in large scale of Klebsiella pneumoniae. Therefore, this study aims to determine the prevalence of different TA loci in clinical and environmental K. pneumoniae isolates. For this reason, 48 K. pneumoniae clinical isolates and 49 K. pneumoniae environmental isolates were subjected for evaluation of different TA loci. The results of current study indicated that there is no association between antibiotic resistances and presence of TA loci in clinical and environmental K. pneumoniae. The role of TA loci as a potent target in antibiotic resistant K. pneumoniae has been complicated. Therefore, more studies should be performed to explain why TA loci are presented in K. pneumoniae and what is the rationale behind antibiotic resistant K. pneumoniae?. Malaysian Society of Parasitology and Tropical Medicine 2016-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/53071/1/The%20rationale%20behind%20antibiotic%20resistance%20pattern%20in%20Klebsiella%20pneumonia.pdf Valian, F. and Sadeghifard, N. and Pakzad, I. and Valizadeh, N. and Karami, Shahriar and Badakhsh, Badakhsh and Sekawi, Zamberi and Taherikalani, M. and Valadbeigi, H. and Ghafourian, Sobhan (2016) The rationale behind antibiotic resistance pattern in Klebsiella pneumoniae. Tropical Biomedicine, 33 (2). pp. 383-386. ISSN 0127-5720 http://www.msptm.org/journal.html |
| spellingShingle | Valian, F. Sadeghifard, N. Pakzad, I. Valizadeh, N. Karami, Shahriar Badakhsh, Badakhsh Sekawi, Zamberi Taherikalani, M. Valadbeigi, H. Ghafourian, Sobhan The rationale behind antibiotic resistance pattern in Klebsiella pneumoniae |
| title | The rationale behind antibiotic resistance pattern in Klebsiella pneumoniae |
| title_full | The rationale behind antibiotic resistance pattern in Klebsiella pneumoniae |
| title_fullStr | The rationale behind antibiotic resistance pattern in Klebsiella pneumoniae |
| title_full_unstemmed | The rationale behind antibiotic resistance pattern in Klebsiella pneumoniae |
| title_short | The rationale behind antibiotic resistance pattern in Klebsiella pneumoniae |
| title_sort | rationale behind antibiotic resistance pattern in klebsiella pneumoniae |
| url | http://psasir.upm.edu.my/id/eprint/53071/1/The%20rationale%20behind%20antibiotic%20resistance%20pattern%20in%20Klebsiella%20pneumonia.pdf |
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