New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II)
A series of aminoanthraquinone derivatives were synthesized via two reaction steps. The starting material of 1,4-dihydroxyanthraquinone (1) was subjected toamination and the major product obtained was then further reacted under reduction, methylation and acylation separately to produce 2-(butylamino...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/53379/1/New%20synthesised%20aminoanthraquinone%20derivatives.pdf |
| _version_ | 1825930841647218688 |
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| author | Juhan, Siti Fadilah Md Sukari, Mohd Aspollah Syed Abdul Azziz, Saripah Salbiah Wong, Chee Fah Alimon, Hasimah Mohd Nor, Siti Mariam |
| author_facet | Juhan, Siti Fadilah Md Sukari, Mohd Aspollah Syed Abdul Azziz, Saripah Salbiah Wong, Chee Fah Alimon, Hasimah Mohd Nor, Siti Mariam |
| author_sort | Juhan, Siti Fadilah |
| collection | UPM |
| description | A series of aminoanthraquinone derivatives were synthesized via two reaction steps. The starting material of 1,4-dihydroxyanthraquinone (1) was subjected toamination and the major product obtained was then further reacted under reduction, methylation and acylation separately to produce 2-(butylamino)anthracene-1,4-dione (2), 2-(butylamino)-1-hydroxy-4-methoxyanthracene-9,10-dione (9), 2-(butylamino)-1,4-dimethoxyanthracene-9,10-dione (10), 3-(butylamino)-4-hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-yl-acetate (11), 2-(butylamino)-4-hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-yl-acetate (12) and 2-(butylamino)-9,10-dioxo-9,10-dihydroanthracene-1-yl-acetate (13). Aminoanthraquinone13 exhibitedstrong antimicrobial activities toward Methicillin-Resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Candida albicans and Escherichia coli with MIC values of 0.1, 0.1, 0.1 and 0.5 mg/mL respectively. Aminoanthraquinones 9, 10 and 13 showed strong cytotoxicity against both MCF-7 (IC50 2.0-11.0μg/mL)and Hep-G2 (IC50 1.1-14.0μg/mL) cell lines. |
| first_indexed | 2024-03-06T09:17:42Z |
| format | Article |
| id | upm.eprints-53379 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:17:42Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | upm.eprints-533792017-10-25T06:50:42Z http://psasir.upm.edu.my/id/eprint/53379/ New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II) Juhan, Siti Fadilah Md Sukari, Mohd Aspollah Syed Abdul Azziz, Saripah Salbiah Wong, Chee Fah Alimon, Hasimah Mohd Nor, Siti Mariam A series of aminoanthraquinone derivatives were synthesized via two reaction steps. The starting material of 1,4-dihydroxyanthraquinone (1) was subjected toamination and the major product obtained was then further reacted under reduction, methylation and acylation separately to produce 2-(butylamino)anthracene-1,4-dione (2), 2-(butylamino)-1-hydroxy-4-methoxyanthracene-9,10-dione (9), 2-(butylamino)-1,4-dimethoxyanthracene-9,10-dione (10), 3-(butylamino)-4-hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-yl-acetate (11), 2-(butylamino)-4-hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-yl-acetate (12) and 2-(butylamino)-9,10-dioxo-9,10-dihydroanthracene-1-yl-acetate (13). Aminoanthraquinone13 exhibitedstrong antimicrobial activities toward Methicillin-Resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Candida albicans and Escherichia coli with MIC values of 0.1, 0.1, 0.1 and 0.5 mg/mL respectively. Aminoanthraquinones 9, 10 and 13 showed strong cytotoxicity against both MCF-7 (IC50 2.0-11.0μg/mL)and Hep-G2 (IC50 1.1-14.0μg/mL) cell lines. 2016-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/53379/1/New%20synthesised%20aminoanthraquinone%20derivatives.pdf Juhan, Siti Fadilah and Md Sukari, Mohd Aspollah and Syed Abdul Azziz, Saripah Salbiah and Wong, Chee Fah and Alimon, Hasimah and Mohd Nor, Siti Mariam (2016) New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II). International Journal of Contemporary Applied Sciences, 3 (1). pp. 18-33. ISSN 2308-1365 |
| spellingShingle | Juhan, Siti Fadilah Md Sukari, Mohd Aspollah Syed Abdul Azziz, Saripah Salbiah Wong, Chee Fah Alimon, Hasimah Mohd Nor, Siti Mariam New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II) |
| title | New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II) |
| title_full | New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II) |
| title_fullStr | New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II) |
| title_full_unstemmed | New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II) |
| title_short | New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II) |
| title_sort | new synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities route ii |
| url | http://psasir.upm.edu.my/id/eprint/53379/1/New%20synthesised%20aminoanthraquinone%20derivatives.pdf |
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