No compensatory relationship between the innate and adaptive immune system in wild-living European badgers
The innate immune system provides the primary vertebrate defence system against pathogen invasion, but it is energetically costly and can have immune pathological effects. A previous study in sticklebacks found that intermediate major histocompatibility complex (MHC) diversity correlated with a lowe...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/53388/1/No%20compensatory%20relationship%20between%20the%20innate%20and%20adaptive%20immune%20system.pdf |
| _version_ | 1796975878315442176 |
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| author | Sin, Yung Wa Newman, Chris Dugdale, Hannah L. Buesching, Christina Mannarelli, Maria-Elena Annavi, Geetha Burke, Terry Macdonald, David W. |
| author_facet | Sin, Yung Wa Newman, Chris Dugdale, Hannah L. Buesching, Christina Mannarelli, Maria-Elena Annavi, Geetha Burke, Terry Macdonald, David W. |
| author_sort | Sin, Yung Wa |
| collection | UPM |
| description | The innate immune system provides the primary vertebrate defence system against pathogen invasion, but it is energetically costly and can have immune pathological effects. A previous study in sticklebacks found that intermediate major histocompatibility complex (MHC) diversity correlated with a lower leukocyte coping capacity (LCC), compared to individuals with fewer, or many, MHC alleles. The organization of the MHC genes in mammals, however, differs to the highly duplicated MHC genes in sticklebacks by having far fewer loci. Using European badgers (Meles meles), we therefore investigated whether innate immune activity, estimated functionally as the ability of an individual’s leukocytes to produce a respiratory burst, was influenced by MHC diversity. We also investigated whether LCC was influenced by factors such as age-class, sex, body condition, season, year, neutrophil and lymphocyte counts, and intensity of infection with five different pathogens. We found that LCC was not associated with specific MHC haplotypes, MHC alleles, or MHC diversity, indicating that the innate immune system did not compensate for the adaptive immune system even when there were susceptible MHC alleles/haplotypes, or when the MHC diversity was low. We also identified a seasonal and annual variation of LCC. This temporal variation of innate immunity was potentially due to physiological trade-offs or temporal variation in pathogen infections. The innate immunity, estimated as LCC, does not compensate for MHC diversity suggests that the immune system may function differently between vertebrates with different MHC organizations, with implications for the evolution of immune systems in different taxa. |
| first_indexed | 2024-03-06T09:17:43Z |
| format | Article |
| id | upm.eprints-53388 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:17:43Z |
| publishDate | 2016 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | upm.eprints-533882019-10-01T02:19:53Z http://psasir.upm.edu.my/id/eprint/53388/ No compensatory relationship between the innate and adaptive immune system in wild-living European badgers Sin, Yung Wa Newman, Chris Dugdale, Hannah L. Buesching, Christina Mannarelli, Maria-Elena Annavi, Geetha Burke, Terry Macdonald, David W. The innate immune system provides the primary vertebrate defence system against pathogen invasion, but it is energetically costly and can have immune pathological effects. A previous study in sticklebacks found that intermediate major histocompatibility complex (MHC) diversity correlated with a lower leukocyte coping capacity (LCC), compared to individuals with fewer, or many, MHC alleles. The organization of the MHC genes in mammals, however, differs to the highly duplicated MHC genes in sticklebacks by having far fewer loci. Using European badgers (Meles meles), we therefore investigated whether innate immune activity, estimated functionally as the ability of an individual’s leukocytes to produce a respiratory burst, was influenced by MHC diversity. We also investigated whether LCC was influenced by factors such as age-class, sex, body condition, season, year, neutrophil and lymphocyte counts, and intensity of infection with five different pathogens. We found that LCC was not associated with specific MHC haplotypes, MHC alleles, or MHC diversity, indicating that the innate immune system did not compensate for the adaptive immune system even when there were susceptible MHC alleles/haplotypes, or when the MHC diversity was low. We also identified a seasonal and annual variation of LCC. This temporal variation of innate immunity was potentially due to physiological trade-offs or temporal variation in pathogen infections. The innate immunity, estimated as LCC, does not compensate for MHC diversity suggests that the immune system may function differently between vertebrates with different MHC organizations, with implications for the evolution of immune systems in different taxa. Public Library of Science 2016-10 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/53388/1/No%20compensatory%20relationship%20between%20the%20innate%20and%20adaptive%20immune%20system.pdf Sin, Yung Wa and Newman, Chris and Dugdale, Hannah L. and Buesching, Christina and Mannarelli, Maria-Elena and Annavi, Geetha and Burke, Terry and Macdonald, David W. (2016) No compensatory relationship between the innate and adaptive immune system in wild-living European badgers. PLOS ONE, 11 (10). art. no. e0163773. pp. 1-16. ISSN 1932-6203 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163773 10.1371/journal.pone.0163773 |
| spellingShingle | Sin, Yung Wa Newman, Chris Dugdale, Hannah L. Buesching, Christina Mannarelli, Maria-Elena Annavi, Geetha Burke, Terry Macdonald, David W. No compensatory relationship between the innate and adaptive immune system in wild-living European badgers |
| title | No compensatory relationship between the innate and adaptive immune system in wild-living European badgers |
| title_full | No compensatory relationship between the innate and adaptive immune system in wild-living European badgers |
| title_fullStr | No compensatory relationship between the innate and adaptive immune system in wild-living European badgers |
| title_full_unstemmed | No compensatory relationship between the innate and adaptive immune system in wild-living European badgers |
| title_short | No compensatory relationship between the innate and adaptive immune system in wild-living European badgers |
| title_sort | no compensatory relationship between the innate and adaptive immune system in wild living european badgers |
| url | http://psasir.upm.edu.my/id/eprint/53388/1/No%20compensatory%20relationship%20between%20the%20innate%20and%20adaptive%20immune%20system.pdf |
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