Detection of active site conformation changes of gamma-secretase, a key enzyme associated with Alzheimer disease, with small molecules

Detection of active site conformation changes of gamma-secretase, a key enzyme associated with Alzheimer disease, with small molecules

Gamma-secretase is a membrane-bound aspartyl-protease that cleaves many membrane substrates including Amyloid Precursor Protein (APP), Notch, E-cadherin, Her4 and CD44. APP is a particularly notable substrate because of its association with Alzheimer disease. Together, gamma-secretase and beta-secre...

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Bibliographic Details
Main Authors: Gertsik, Natalya, Li, Yue Ming, Chau, De Ming
Format: Conference or Workshop Item
Language:English
Published: 2016
Online Access:http://psasir.upm.edu.my/id/eprint/53874/1/Detection%20of%20active%20site%20conformation%20changes%20of%20gamma-secretase%2C%20a%20key%20enzyme%20associated%20with%20Alzheimer%20disease%2C%20with%20small%20molecules.pdf

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http://psasir.upm.edu.my/id/eprint/53874/1/Detection%20of%20active%20site%20conformation%20changes%20of%20gamma-secretase%2C%20a%20key%20enzyme%20associated%20with%20Alzheimer%20disease%2C%20with%20small%20molecules.pdf

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