Structure–activity relationship study of secondary metabolites from Mesua beccariana, Mesua ferrea and Mesua congestiflora for anti-cholinesterase activity
Our search for potential anti-acetylcholinesterase (AChE) inhibitors for treatment of Alzheimer’s disease has led to the discovery of two bioactive compounds, α-mangostin (11) and congestiflorone acetate (13). This discovery was achieved from a preliminary screening of the anti-AChE activity on the...
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| Format: | Article |
| Language: | English |
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Springer Verlag
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/53914/1/Structure%E2%80%93activity%20relationship%20study%20of%20secondary%20metabolites%20from%20Mesua%20beccariana.pdf |
| _version_ | 1796975980544262144 |
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| author | Teh, Soek Sin Cheng, Gwendoline Lian Ee Mah, Siau Hui Ahmad, Zuraini |
| author_facet | Teh, Soek Sin Cheng, Gwendoline Lian Ee Mah, Siau Hui Ahmad, Zuraini |
| author_sort | Teh, Soek Sin |
| collection | UPM |
| description | Our search for potential anti-acetylcholinesterase (AChE) inhibitors for treatment of Alzheimer’s disease has led to the discovery of two bioactive compounds, α-mangostin (11) and congestiflorone acetate (13). This discovery was achieved from a preliminary screening of the anti-AChE activity on the extracts of three Mesua species namely M. ferrea, M. beccariana and M. congestiflora using Ellman’s method. The pure metabolites, 1–12 which were isolated from the Mesua species, along with a synthetic derivative, compound 13 were then evaluated for their activities in order to identify the compounds that correspond to the enzyme inhibitory activities. Compounds 11 and 13 were found to give significant anti-AChE activities with IC50 values of 17.51 and 20.25 µM. |
| first_indexed | 2024-03-06T09:19:12Z |
| format | Article |
| id | upm.eprints-53914 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:19:12Z |
| publishDate | 2016 |
| publisher | Springer Verlag |
| record_format | dspace |
| spelling | upm.eprints-539142018-02-21T03:52:13Z http://psasir.upm.edu.my/id/eprint/53914/ Structure–activity relationship study of secondary metabolites from Mesua beccariana, Mesua ferrea and Mesua congestiflora for anti-cholinesterase activity Teh, Soek Sin Cheng, Gwendoline Lian Ee Mah, Siau Hui Ahmad, Zuraini Our search for potential anti-acetylcholinesterase (AChE) inhibitors for treatment of Alzheimer’s disease has led to the discovery of two bioactive compounds, α-mangostin (11) and congestiflorone acetate (13). This discovery was achieved from a preliminary screening of the anti-AChE activity on the extracts of three Mesua species namely M. ferrea, M. beccariana and M. congestiflora using Ellman’s method. The pure metabolites, 1–12 which were isolated from the Mesua species, along with a synthetic derivative, compound 13 were then evaluated for their activities in order to identify the compounds that correspond to the enzyme inhibitory activities. Compounds 11 and 13 were found to give significant anti-AChE activities with IC50 values of 17.51 and 20.25 µM. Springer Verlag 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/53914/1/Structure%E2%80%93activity%20relationship%20study%20of%20secondary%20metabolites%20from%20Mesua%20beccariana.pdf Teh, Soek Sin and Cheng, Gwendoline Lian Ee and Mah, Siau Hui and Ahmad, Zuraini (2016) Structure–activity relationship study of secondary metabolites from Mesua beccariana, Mesua ferrea and Mesua congestiflora for anti-cholinesterase activity. Medicinal Chemistry Research, 25 (5). pp. 819-823. ISSN 1054-2523; ESSN: 1554-8120 https://link.springer.com/article/10.1007/s00044-016-1531-0 Anti-acetylcholinesterase; Mesua ferrea; Mesua beccariana; Mesua congestiflora; α-mangostin; Congestiflorone acetate 10.1007/s00044-016-1531-0 |
| spellingShingle | Anti-acetylcholinesterase; Mesua ferrea; Mesua beccariana; Mesua congestiflora; α-mangostin; Congestiflorone acetate Teh, Soek Sin Cheng, Gwendoline Lian Ee Mah, Siau Hui Ahmad, Zuraini Structure–activity relationship study of secondary metabolites from Mesua beccariana, Mesua ferrea and Mesua congestiflora for anti-cholinesterase activity |
| title | Structure–activity relationship study of secondary metabolites from Mesua beccariana, Mesua ferrea and Mesua congestiflora for anti-cholinesterase activity |
| title_full | Structure–activity relationship study of secondary metabolites from Mesua beccariana, Mesua ferrea and Mesua congestiflora for anti-cholinesterase activity |
| title_fullStr | Structure–activity relationship study of secondary metabolites from Mesua beccariana, Mesua ferrea and Mesua congestiflora for anti-cholinesterase activity |
| title_full_unstemmed | Structure–activity relationship study of secondary metabolites from Mesua beccariana, Mesua ferrea and Mesua congestiflora for anti-cholinesterase activity |
| title_short | Structure–activity relationship study of secondary metabolites from Mesua beccariana, Mesua ferrea and Mesua congestiflora for anti-cholinesterase activity |
| title_sort | structure activity relationship study of secondary metabolites from mesua beccariana mesua ferrea and mesua congestiflora for anti cholinesterase activity |
| topic | Anti-acetylcholinesterase; Mesua ferrea; Mesua beccariana; Mesua congestiflora; α-mangostin; Congestiflorone acetate |
| url | http://psasir.upm.edu.my/id/eprint/53914/1/Structure%E2%80%93activity%20relationship%20study%20of%20secondary%20metabolites%20from%20Mesua%20beccariana.pdf |
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