In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates
Four compounds, R3PAu[S2CN(CH2CH2OH)2], R = Ph (1) and cyclohexyl (2), and Et3PAuS2CNRꞌ2, Rꞌ = Rꞌ = Et (3) and Rꞌ2 = (CH2)4 (4), have been evaluated for antibacterial activity against a panel of 24 Gram positive (8) and Gram negative (16) bacteria. Based on minimum inhibitory concentration (MIC) sco...
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| Format: | Article |
| Language: | English |
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Elsevier
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/54533/1/In%20vitro%20antibacterial%20and%20time%20kill%20evaluation%20of%20mononuclear%20phosphanegold%20%28I%29%20dithiocarbamates.pdf |
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| author | Chen, Bao Jing Jamaludin, Nazzatush Shimar Khoo, Chai Hoon See, Tian Hong Sim, Jiun Horng Cheah, Yoke Kqueen Abdul Halim, Siti Nadiah Seng, Hoi Ling Tiekink, Edward R.T. |
| author_facet | Chen, Bao Jing Jamaludin, Nazzatush Shimar Khoo, Chai Hoon See, Tian Hong Sim, Jiun Horng Cheah, Yoke Kqueen Abdul Halim, Siti Nadiah Seng, Hoi Ling Tiekink, Edward R.T. |
| author_sort | Chen, Bao Jing |
| collection | UPM |
| description | Four compounds, R3PAu[S2CN(CH2CH2OH)2], R = Ph (1) and cyclohexyl (2), and Et3PAuS2CNRꞌ2, Rꞌ = Rꞌ = Et (3) and Rꞌ2 = (CH2)4 (4), have been evaluated for antibacterial activity against a panel of 24 Gram positive (8) and Gram negative (16) bacteria. Based on minimum inhibitory concentration (MIC) scores, compounds 1 and 2 were shown to be specifically potent against Gram positive bacteria whereas compounds 3 and, to a lesser extent, 4 exhibited broad range activity. All four compounds were active against methicillin resistant Staphylococcus aureus (MRSA). Time kill assays revealed the compounds to exhibit both time- and concentration-dependent pharmacokinetics against susceptible bacteria. Each compound was bactericidal against one or more bacteria with 3 being especially potent after 8 h exposure; compounds 1 and 3 were bactericidal against MRSA. Compound 3 was the most effective bactericide across the series especially toward B. subtilis, S. saprophyticus, A. hydrophila, P. vulgaris, and V. parahaemolyticus. This study demonstrates the potential of this class of compounds as antibacterial agents, either broad range or against specific bacteria. |
| first_indexed | 2024-03-06T09:20:57Z |
| format | Article |
| id | upm.eprints-54533 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:20:57Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-545332018-03-27T04:29:29Z http://psasir.upm.edu.my/id/eprint/54533/ In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates Chen, Bao Jing Jamaludin, Nazzatush Shimar Khoo, Chai Hoon See, Tian Hong Sim, Jiun Horng Cheah, Yoke Kqueen Abdul Halim, Siti Nadiah Seng, Hoi Ling Tiekink, Edward R.T. Four compounds, R3PAu[S2CN(CH2CH2OH)2], R = Ph (1) and cyclohexyl (2), and Et3PAuS2CNRꞌ2, Rꞌ = Rꞌ = Et (3) and Rꞌ2 = (CH2)4 (4), have been evaluated for antibacterial activity against a panel of 24 Gram positive (8) and Gram negative (16) bacteria. Based on minimum inhibitory concentration (MIC) scores, compounds 1 and 2 were shown to be specifically potent against Gram positive bacteria whereas compounds 3 and, to a lesser extent, 4 exhibited broad range activity. All four compounds were active against methicillin resistant Staphylococcus aureus (MRSA). Time kill assays revealed the compounds to exhibit both time- and concentration-dependent pharmacokinetics against susceptible bacteria. Each compound was bactericidal against one or more bacteria with 3 being especially potent after 8 h exposure; compounds 1 and 3 were bactericidal against MRSA. Compound 3 was the most effective bactericide across the series especially toward B. subtilis, S. saprophyticus, A. hydrophila, P. vulgaris, and V. parahaemolyticus. This study demonstrates the potential of this class of compounds as antibacterial agents, either broad range or against specific bacteria. Elsevier 2016-10 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/54533/1/In%20vitro%20antibacterial%20and%20time%20kill%20evaluation%20of%20mononuclear%20phosphanegold%20%28I%29%20dithiocarbamates.pdf Chen, Bao Jing and Jamaludin, Nazzatush Shimar and Khoo, Chai Hoon and See, Tian Hong and Sim, Jiun Horng and Cheah, Yoke Kqueen and Abdul Halim, Siti Nadiah and Seng, Hoi Ling and Tiekink, Edward R.T. (2016) In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates. Journal of Inorganic Biochemistry, 163. pp. 68-80. ISSN 0162-0134; ESSN: 1873-3344 https://www.sciencedirect.com/science/article/pii/S0162013416302264 Phosphanegold(I) compounds; Dithiocarbamate; Thiolate; Antimicrobial; Time kill assay 10.1016/j.jinorgbio.2016.08.002 |
| spellingShingle | Phosphanegold(I) compounds; Dithiocarbamate; Thiolate; Antimicrobial; Time kill assay Chen, Bao Jing Jamaludin, Nazzatush Shimar Khoo, Chai Hoon See, Tian Hong Sim, Jiun Horng Cheah, Yoke Kqueen Abdul Halim, Siti Nadiah Seng, Hoi Ling Tiekink, Edward R.T. In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates |
| title | In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates |
| title_full | In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates |
| title_fullStr | In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates |
| title_full_unstemmed | In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates |
| title_short | In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates |
| title_sort | in vitro antibacterial and time kill evaluation of mononuclear phosphanegold i dithiocarbamates |
| topic | Phosphanegold(I) compounds; Dithiocarbamate; Thiolate; Antimicrobial; Time kill assay |
| url | http://psasir.upm.edu.my/id/eprint/54533/1/In%20vitro%20antibacterial%20and%20time%20kill%20evaluation%20of%20mononuclear%20phosphanegold%20%28I%29%20dithiocarbamates.pdf |
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