Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats
Introduction: This study was conducted to determine immunological and metabolic effects of different concentrations of ginger rhizome (Zingiber officinale Roscoe) in streptozotocin (STZ)-nicotinamide (NA) induced diabetic rats. Methods: Forty-eight fasted male Sprague-Dawley rats were induced diabet...
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| Format: | Article |
| Language: | English |
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Nutrition Society of Malaysia
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/54791/1/Metabolic%20and%20immunologic%20alterations%20of%20ginger%20rhizome%20among%20streptozotocin-nicotinamide%20induced%20diabetic%20rats.pdf |
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| author | Mojani, Mansooreh Sadat Rahmat, Asmah Ramasamy, Rajesh Sarmadi, Vahid Hosseinpour Sandrasaigaran, Pratheep Vellasamy, Shalini Hejazi, Seyed Majid Akhavan |
| author_facet | Mojani, Mansooreh Sadat Rahmat, Asmah Ramasamy, Rajesh Sarmadi, Vahid Hosseinpour Sandrasaigaran, Pratheep Vellasamy, Shalini Hejazi, Seyed Majid Akhavan |
| author_sort | Mojani, Mansooreh Sadat |
| collection | UPM |
| description | Introduction: This study was conducted to determine immunological and metabolic effects of different concentrations of ginger rhizome (Zingiber officinale Roscoe) in streptozotocin (STZ)-nicotinamide (NA) induced diabetic rats. Methods: Forty-eight fasted male Sprague-Dawley rats were induced diabetes using a single intraperitoneal injection of NA(110 mg/kg b.w.) and STZ (65 mg/kg b.w, 15 min after NA). Diabetic rats orally received either different concentrations (250, 500 and 750 mg/kg body weight) of ginger rhizome suspension or glibenclamide (10 mg/kg body weight) for 6 weeks. Two control diabetic and normal groups were gavaged with only distilled water as a vehicle. Results: The results indicated that the lower concentrations of ginger modulated body weight, fasting blood glucose, level of triglyceride and tumor necrosis factor-α (TNF-α) (p<0.05). In contrast, ginger could not enhance atherogenic indices due to a decline in the level of HDL-c. Immunological features of ginger were evident by a significant lymphocyte proliferation in all treated groups at stimulation by 5 mg/ml PHA (p<0.001). Level of CD45ra+ (B cell marker) increased significantly in the lowest dose of ginger (p<0.05, 58%), and 250 mg/kg body weight of ginger was found to be safe for not altering the level of CD4+CD25+ marker (p>0.05). Conclusion: Ginger indicated better impact on metabolic and immunologic parameters in lower doses of supplementation compared with high doses of treatment. |
| first_indexed | 2024-03-06T09:21:34Z |
| format | Article |
| id | upm.eprints-54791 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:21:34Z |
| publishDate | 2016 |
| publisher | Nutrition Society of Malaysia |
| record_format | dspace |
| spelling | upm.eprints-547912018-04-24T04:59:49Z http://psasir.upm.edu.my/id/eprint/54791/ Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats Mojani, Mansooreh Sadat Rahmat, Asmah Ramasamy, Rajesh Sarmadi, Vahid Hosseinpour Sandrasaigaran, Pratheep Vellasamy, Shalini Hejazi, Seyed Majid Akhavan Introduction: This study was conducted to determine immunological and metabolic effects of different concentrations of ginger rhizome (Zingiber officinale Roscoe) in streptozotocin (STZ)-nicotinamide (NA) induced diabetic rats. Methods: Forty-eight fasted male Sprague-Dawley rats were induced diabetes using a single intraperitoneal injection of NA(110 mg/kg b.w.) and STZ (65 mg/kg b.w, 15 min after NA). Diabetic rats orally received either different concentrations (250, 500 and 750 mg/kg body weight) of ginger rhizome suspension or glibenclamide (10 mg/kg body weight) for 6 weeks. Two control diabetic and normal groups were gavaged with only distilled water as a vehicle. Results: The results indicated that the lower concentrations of ginger modulated body weight, fasting blood glucose, level of triglyceride and tumor necrosis factor-α (TNF-α) (p<0.05). In contrast, ginger could not enhance atherogenic indices due to a decline in the level of HDL-c. Immunological features of ginger were evident by a significant lymphocyte proliferation in all treated groups at stimulation by 5 mg/ml PHA (p<0.001). Level of CD45ra+ (B cell marker) increased significantly in the lowest dose of ginger (p<0.05, 58%), and 250 mg/kg body weight of ginger was found to be safe for not altering the level of CD4+CD25+ marker (p>0.05). Conclusion: Ginger indicated better impact on metabolic and immunologic parameters in lower doses of supplementation compared with high doses of treatment. Nutrition Society of Malaysia 2016 Article NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/54791/1/Metabolic%20and%20immunologic%20alterations%20of%20ginger%20rhizome%20among%20streptozotocin-nicotinamide%20induced%20diabetic%20rats.pdf Mojani, Mansooreh Sadat and Rahmat, Asmah and Ramasamy, Rajesh and Sarmadi, Vahid Hosseinpour and Sandrasaigaran, Pratheep and Vellasamy, Shalini and Hejazi, Seyed Majid Akhavan (2016) Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats. Malaysian Journal of Nutrition, 22 (3). pp. 421-432. ISSN 1394-035X https://www.cabdirect.org/cabdirect/abstract/20173161042 |
| spellingShingle | Mojani, Mansooreh Sadat Rahmat, Asmah Ramasamy, Rajesh Sarmadi, Vahid Hosseinpour Sandrasaigaran, Pratheep Vellasamy, Shalini Hejazi, Seyed Majid Akhavan Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats |
| title | Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats |
| title_full | Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats |
| title_fullStr | Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats |
| title_full_unstemmed | Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats |
| title_short | Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats |
| title_sort | metabolic and immunologic alterations of ginger rhizome among streptozotocin nicotinamide induced diabetic rats |
| url | http://psasir.upm.edu.my/id/eprint/54791/1/Metabolic%20and%20immunologic%20alterations%20of%20ginger%20rhizome%20among%20streptozotocin-nicotinamide%20induced%20diabetic%20rats.pdf |
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