Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro
Endothelial dysfunction has been implicated in the pathogenesis of atherosclerosis. Salvia miltiorrhiza (danshen) is a traditional Chinese medicine that has been effectively used to treat cardiovascular disease. Cryptotanshinone (CTS), a major lipophilic compound isolated from S. miltiorrhiza, has b...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/55402/1/Cryptotanshinone%20inhibits%20TNF-%CE%B1-induced%20early%20atherogenic%20events%20in%20.pdf |
| _version_ | 1825931211751555072 |
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| author | Ahmad, Zuraini Chin, Theng Ng Lai, Yen Fong Abu Bakar, Nurul Ain Mohd Hussain, Nor Hayuti Kok, Pian Ang Cheng , Gwendoline Lian Ee , Muhammad Nazrul Hakim |
| author_facet | Ahmad, Zuraini Chin, Theng Ng Lai, Yen Fong Abu Bakar, Nurul Ain Mohd Hussain, Nor Hayuti Kok, Pian Ang Cheng , Gwendoline Lian Ee , Muhammad Nazrul Hakim |
| author_sort | Ahmad, Zuraini |
| collection | UPM |
| description | Endothelial dysfunction has been implicated in the pathogenesis of atherosclerosis. Salvia miltiorrhiza (danshen) is a traditional Chinese medicine that has been effectively used to treat cardiovascular disease. Cryptotanshinone (CTS), a major lipophilic compound isolated from S. miltiorrhiza, has been reported to possess cardioprotective effects. However, the anti-atherogenic effects of CTS, particularly on tumor necrosis factor-α (TNF-α)-induced endothelial cell activation, are still unclear. This study aimed to determine the effect of CTS on TNF-α-induced increased endothelial permeability, monocyte adhesion, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), monocyte chemoattractant protein 1 (MCP-1) and impaired nitric oxide production in human umbilical vein endothelial cells (HUVECs), all of which are early events occurring in atherogenesis. We showed that CTS significantly suppressed TNF-α-induced increased endothelial permeability, monocyte adhesion, sICAM-1, sVCAM-1 and MCP-1, and restored nitric oxide production. These observations suggest that CTS possesses anti-inflammatory properties and could be a promising treatment for the prevention of cytokine-induced early atherogenesis. |
| first_indexed | 2024-03-06T09:23:18Z |
| format | Article |
| id | upm.eprints-55402 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:23:18Z |
| publishDate | 2016 |
| publisher | Springer |
| record_format | dspace |
| spelling | upm.eprints-554022017-10-02T09:20:24Z http://psasir.upm.edu.my/id/eprint/55402/ Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro Ahmad, Zuraini Chin, Theng Ng Lai, Yen Fong Abu Bakar, Nurul Ain Mohd Hussain, Nor Hayuti Kok, Pian Ang Cheng , Gwendoline Lian Ee , Muhammad Nazrul Hakim Endothelial dysfunction has been implicated in the pathogenesis of atherosclerosis. Salvia miltiorrhiza (danshen) is a traditional Chinese medicine that has been effectively used to treat cardiovascular disease. Cryptotanshinone (CTS), a major lipophilic compound isolated from S. miltiorrhiza, has been reported to possess cardioprotective effects. However, the anti-atherogenic effects of CTS, particularly on tumor necrosis factor-α (TNF-α)-induced endothelial cell activation, are still unclear. This study aimed to determine the effect of CTS on TNF-α-induced increased endothelial permeability, monocyte adhesion, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), monocyte chemoattractant protein 1 (MCP-1) and impaired nitric oxide production in human umbilical vein endothelial cells (HUVECs), all of which are early events occurring in atherogenesis. We showed that CTS significantly suppressed TNF-α-induced increased endothelial permeability, monocyte adhesion, sICAM-1, sVCAM-1 and MCP-1, and restored nitric oxide production. These observations suggest that CTS possesses anti-inflammatory properties and could be a promising treatment for the prevention of cytokine-induced early atherogenesis. Springer 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/55402/1/Cryptotanshinone%20inhibits%20TNF-%CE%B1-induced%20early%20atherogenic%20events%20in%20.pdf Ahmad, Zuraini and Chin, Theng Ng and Lai, Yen Fong and Abu Bakar, Nurul Ain and Mohd Hussain, Nor Hayuti and Kok, Pian Ang and Cheng , Gwendoline Lian Ee and , Muhammad Nazrul Hakim (2016) Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro. The Journal of Physiological Sciences, 66 (3). pp. 213-220. ISSN 1880-6546 10.1007/s12576-015-0410-7 |
| spellingShingle | Ahmad, Zuraini Chin, Theng Ng Lai, Yen Fong Abu Bakar, Nurul Ain Mohd Hussain, Nor Hayuti Kok, Pian Ang Cheng , Gwendoline Lian Ee , Muhammad Nazrul Hakim Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro |
| title | Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro |
| title_full | Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro |
| title_fullStr | Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro |
| title_full_unstemmed | Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro |
| title_short | Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro |
| title_sort | cryptotanshinone inhibits tnf α induced early atherogenic events in vitro |
| url | http://psasir.upm.edu.my/id/eprint/55402/1/Cryptotanshinone%20inhibits%20TNF-%CE%B1-induced%20early%20atherogenic%20events%20in%20.pdf |
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