Cytotoxic prenylated xanthone and coumarin derivatives from Malaysian Mesua beccariana
Our recent research on the phytochemical constituents of the stem bark of Mesua beccariana gave one new xanthone, beccarixanthone T (1) and one new coumarin, beccamarin T (2) together with three known xanthones mesuarianone (3), mesuasinone (4), 1,5-dihydroxyxanthone (5) and four known terpenoids, f...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/55415/1/Cytotoxic%20prenylated%20xanthone%20and%20coumarin%20derivatives%20from%20Malaysian%20Mesua%20beccariana.pdf |
| _version_ | 1825931214442201088 |
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| author | Karunakaran, Thiruventhan Ee, Gwendoline C. L. Keng, H. Tee Ismail, Intan S. Zamakshshari, Nor H. Peter, Waziri M. |
| author_facet | Karunakaran, Thiruventhan Ee, Gwendoline C. L. Keng, H. Tee Ismail, Intan S. Zamakshshari, Nor H. Peter, Waziri M. |
| author_sort | Karunakaran, Thiruventhan |
| collection | UPM |
| description | Our recent research on the phytochemical constituents of the stem bark of Mesua beccariana gave one new xanthone, beccarixanthone T (1) and one new coumarin, beccamarin T (2) together with three known xanthones mesuarianone (3), mesuasinone (4), 1,5-dihydroxyxanthone (5) and four known terpenoids, friedelin (6), stigmasterol (7), beta-sitosterol (8) and gamma-sitosterol (9). The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS. The cytotoxic activities of compounds 1-4 as well as the crude extracts were tested against two cancer cell lines, Hep G2 (liver cancer cell line) and HT-29 (colon cancer cell line) using MTT assays. Mesuarianone (3) gave a significant activity on the HT-29 cell line while mesuasinone (4) gave moderate activity against HT-29 cell line. |
| first_indexed | 2024-03-06T09:23:21Z |
| format | Article |
| id | upm.eprints-55415 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:23:21Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-554152017-10-02T06:23:33Z http://psasir.upm.edu.my/id/eprint/55415/ Cytotoxic prenylated xanthone and coumarin derivatives from Malaysian Mesua beccariana Karunakaran, Thiruventhan Ee, Gwendoline C. L. Keng, H. Tee Ismail, Intan S. Zamakshshari, Nor H. Peter, Waziri M. Our recent research on the phytochemical constituents of the stem bark of Mesua beccariana gave one new xanthone, beccarixanthone T (1) and one new coumarin, beccamarin T (2) together with three known xanthones mesuarianone (3), mesuasinone (4), 1,5-dihydroxyxanthone (5) and four known terpenoids, friedelin (6), stigmasterol (7), beta-sitosterol (8) and gamma-sitosterol (9). The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS. The cytotoxic activities of compounds 1-4 as well as the crude extracts were tested against two cancer cell lines, Hep G2 (liver cancer cell line) and HT-29 (colon cancer cell line) using MTT assays. Mesuarianone (3) gave a significant activity on the HT-29 cell line while mesuasinone (4) gave moderate activity against HT-29 cell line. Elsevier 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/55415/1/Cytotoxic%20prenylated%20xanthone%20and%20coumarin%20derivatives%20from%20Malaysian%20Mesua%20beccariana.pdf Karunakaran, Thiruventhan and Ee, Gwendoline C. L. and Keng, H. Tee and Ismail, Intan S. and Zamakshshari, Nor H. and Peter, Waziri M. (2016) Cytotoxic prenylated xanthone and coumarin derivatives from Malaysian Mesua beccariana. Phytochemistry Letters, 17 (2016). pp. 131-134. ISSN 1874-3900; ESSN: 1876-7486 http://www.sciencedirect.com/science/article/pii/S1874390016301239 10.1016/j.phytol.2016.07.026 |
| spellingShingle | Karunakaran, Thiruventhan Ee, Gwendoline C. L. Keng, H. Tee Ismail, Intan S. Zamakshshari, Nor H. Peter, Waziri M. Cytotoxic prenylated xanthone and coumarin derivatives from Malaysian Mesua beccariana |
| title | Cytotoxic prenylated xanthone and coumarin derivatives from Malaysian Mesua beccariana |
| title_full | Cytotoxic prenylated xanthone and coumarin derivatives from Malaysian Mesua beccariana |
| title_fullStr | Cytotoxic prenylated xanthone and coumarin derivatives from Malaysian Mesua beccariana |
| title_full_unstemmed | Cytotoxic prenylated xanthone and coumarin derivatives from Malaysian Mesua beccariana |
| title_short | Cytotoxic prenylated xanthone and coumarin derivatives from Malaysian Mesua beccariana |
| title_sort | cytotoxic prenylated xanthone and coumarin derivatives from malaysian mesua beccariana |
| url | http://psasir.upm.edu.my/id/eprint/55415/1/Cytotoxic%20prenylated%20xanthone%20and%20coumarin%20derivatives%20from%20Malaysian%20Mesua%20beccariana.pdf |
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