| Summary: | Phytochemical and biological studies were carried out the stem bark of Cratoxylum arborescens collected from Sarawak, Malaysia. Chromatographic separation of the plant extracts led to the isolation of three xanthones, a-mangostin (1), ß-mangostin (2) and fuscaxanthone C (3) together with the commom stigmasterol. The structural elucidation of the compound was determined by detail spectroscopic analysis and comparison with literature reports. a-Mangostin exhibited strong inhibition on the growth of bacteria, B. subtilis, B. cereus, S. typhimurium and S. aureus with inhibition zone of 16, 20, 17 and 20 mm, respectively. Both a-mangostin and ß-mangostin showed the most significant cytotoxic activity against MCF7 cells with IC50 values of 12.48 μg/ml and 28.42 μg/ml, respectively. However, when tested for antioxidant activity by using DPPH, the extracts and the xanthones failed to give good results.
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