Evaluation of the Insulinotrophic Activity of Malaysian Traditional Plants Extract
In this study, methanolic extracts of 14 traditional plants in Malaysia were screened for insulinotrophic properties, using rat pancreatic B-cell lines, BRIN-BD11 cells. In 30min acute static incubation test, all 14 plants showed varying degree of responsivess in insulin release with Labisa pumila,...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
Asian Network for Scientific Information
2008
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/5664/1/Evaluation%20of%20the%20Insulinotrophic%20Activity%20of%20Malaysian%20Traditional%20Plants%20Extract.pdf |
| _version_ | 1796967007588974592 |
|---|---|
| author | Hamid, Muhajir Mohd Bohari, Siti Pauliena Bastami, Mohd Saufi Ali, Abdul Manaf Mustapha, Nik Musa'adah Shari, Khozirah |
| author_facet | Hamid, Muhajir Mohd Bohari, Siti Pauliena Bastami, Mohd Saufi Ali, Abdul Manaf Mustapha, Nik Musa'adah Shari, Khozirah |
| author_sort | Hamid, Muhajir |
| collection | UPM |
| description | In this study, methanolic extracts of 14 traditional plants in Malaysia were screened for insulinotrophic properties, using rat pancreatic B-cell lines, BRIN-BD11 cells. In 30min acute static incubation test, all 14 plants showed varying degree of responsivess in insulin release with Labisa pumila, Morinda charantia and Tinospora crispa having high insulinotrophic activities. These plants also displayed appreciably low cyotoxic activities. These results show a promising avenue for development of novel insulin secretagogues. |
| first_indexed | 2024-03-06T07:07:34Z |
| format | Article |
| id | upm.eprints-5664 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:07:34Z |
| publishDate | 2008 |
| publisher | Asian Network for Scientific Information |
| record_format | dspace |
| spelling | upm.eprints-56642015-09-17T00:59:43Z http://psasir.upm.edu.my/id/eprint/5664/ Evaluation of the Insulinotrophic Activity of Malaysian Traditional Plants Extract Hamid, Muhajir Mohd Bohari, Siti Pauliena Bastami, Mohd Saufi Ali, Abdul Manaf Mustapha, Nik Musa'adah Shari, Khozirah In this study, methanolic extracts of 14 traditional plants in Malaysia were screened for insulinotrophic properties, using rat pancreatic B-cell lines, BRIN-BD11 cells. In 30min acute static incubation test, all 14 plants showed varying degree of responsivess in insulin release with Labisa pumila, Morinda charantia and Tinospora crispa having high insulinotrophic activities. These plants also displayed appreciably low cyotoxic activities. These results show a promising avenue for development of novel insulin secretagogues. Asian Network for Scientific Information 2008 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/5664/1/Evaluation%20of%20the%20Insulinotrophic%20Activity%20of%20Malaysian%20Traditional%20Plants%20Extract.pdf Hamid, Muhajir and Mohd Bohari, Siti Pauliena and Bastami, Mohd Saufi and Ali, Abdul Manaf and Mustapha, Nik Musa'adah and Shari, Khozirah (2008) Evaluation of the Insulinotrophic Activity of Malaysian Traditional Plants Extract. Journal of Biological Sciences, 8 (1). pp. 201-204. ISSN 1727-3048 http://dx.doi.org/10.3923/jbs.2008.201.204 10.3923/jbs.2008.201.204 English |
| spellingShingle | Hamid, Muhajir Mohd Bohari, Siti Pauliena Bastami, Mohd Saufi Ali, Abdul Manaf Mustapha, Nik Musa'adah Shari, Khozirah Evaluation of the Insulinotrophic Activity of Malaysian Traditional Plants Extract |
| title | Evaluation of the Insulinotrophic Activity of Malaysian Traditional Plants Extract |
| title_full | Evaluation of the Insulinotrophic Activity of Malaysian Traditional Plants Extract |
| title_fullStr | Evaluation of the Insulinotrophic Activity of Malaysian Traditional Plants Extract |
| title_full_unstemmed | Evaluation of the Insulinotrophic Activity of Malaysian Traditional Plants Extract |
| title_short | Evaluation of the Insulinotrophic Activity of Malaysian Traditional Plants Extract |
| title_sort | evaluation of the insulinotrophic activity of malaysian traditional plants extract |
| url | http://psasir.upm.edu.my/id/eprint/5664/1/Evaluation%20of%20the%20Insulinotrophic%20Activity%20of%20Malaysian%20Traditional%20Plants%20Extract.pdf |
| work_keys_str_mv | AT hamidmuhajir evaluationoftheinsulinotrophicactivityofmalaysiantraditionalplantsextract AT mohdboharisitipauliena evaluationoftheinsulinotrophicactivityofmalaysiantraditionalplantsextract AT bastamimohdsaufi evaluationoftheinsulinotrophicactivityofmalaysiantraditionalplantsextract AT aliabdulmanaf evaluationoftheinsulinotrophicactivityofmalaysiantraditionalplantsextract AT mustaphanikmusaadah evaluationoftheinsulinotrophicactivityofmalaysiantraditionalplantsextract AT sharikhozirah evaluationoftheinsulinotrophicactivityofmalaysiantraditionalplantsextract |