Nanoparticle preparation of mefenamic acid by electrospray drying
Nanoparticles preparation of Mefenamic acid (MA) by using an electrospray drying method was conducted in this study. Electrospray drying is a process that uses electrostatic force to disperse a conductive liquid stream into fine charged droplets through the coulomb fission of charges in the liquid a...
| Main Authors: | , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
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AIP Publishing LLC
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/57601/1/Nanoparticle%20preparation%20of%20mefenamic%20acid%20by%20electrospray%20drying.pdf |
| _version_ | 1825931644823928832 |
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| author | Zolkepali, Nurul Karimah Abu Bakar, Noor Fitrah Naim, Mohd Nazli Anuar, Nornizar Abu Bakar, Mohd Rushdi |
| author_facet | Zolkepali, Nurul Karimah Abu Bakar, Noor Fitrah Naim, Mohd Nazli Anuar, Nornizar Abu Bakar, Mohd Rushdi |
| author_sort | Zolkepali, Nurul Karimah |
| collection | UPM |
| description | Nanoparticles preparation of Mefenamic acid (MA) by using an electrospray drying method was conducted in this study. Electrospray drying is a process that uses electrostatic force to disperse a conductive liquid stream into fine charged droplets through the coulomb fission of charges in the liquid and finally dry into fine particles. Electrospray drying modes operation usually in Taylor cone jet, and it was formed by controlling applied voltage and liquid flow rate. A conductive liquid (2.77–8.55μScm−1) which is MA solution was prepared by using acetone with concentration 0.041 and 0.055 M before pumping at a flow rate of 3–6ml/h. By applying the applied voltage at 1.3–1.5 kV, Taylor cone jet mode was formed prior to the electrospray. During electrospray drying process, solvent evaporation from the droplet was occurring that leads to coulomb disruption and may generate to nanoparticles. The dried nanoparticles were collected on a grounded substrate that was placed at varying distance from the electrospray. MA particle with size range of 100–400 nm were produced by electrospray drying process. Characterization of particles by using X-ray diffractometry (XRD) and differential scanning calorimetry (DSC) show that particles formed into polymorph I. |
| first_indexed | 2024-03-06T09:29:53Z |
| format | Conference or Workshop Item |
| id | upm.eprints-57601 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:29:53Z |
| publishDate | 2013 |
| publisher | AIP Publishing LLC |
| record_format | dspace |
| spelling | upm.eprints-576012017-10-24T07:34:46Z http://psasir.upm.edu.my/id/eprint/57601/ Nanoparticle preparation of mefenamic acid by electrospray drying Zolkepali, Nurul Karimah Abu Bakar, Noor Fitrah Naim, Mohd Nazli Anuar, Nornizar Abu Bakar, Mohd Rushdi Nanoparticles preparation of Mefenamic acid (MA) by using an electrospray drying method was conducted in this study. Electrospray drying is a process that uses electrostatic force to disperse a conductive liquid stream into fine charged droplets through the coulomb fission of charges in the liquid and finally dry into fine particles. Electrospray drying modes operation usually in Taylor cone jet, and it was formed by controlling applied voltage and liquid flow rate. A conductive liquid (2.77–8.55μScm−1) which is MA solution was prepared by using acetone with concentration 0.041 and 0.055 M before pumping at a flow rate of 3–6ml/h. By applying the applied voltage at 1.3–1.5 kV, Taylor cone jet mode was formed prior to the electrospray. During electrospray drying process, solvent evaporation from the droplet was occurring that leads to coulomb disruption and may generate to nanoparticles. The dried nanoparticles were collected on a grounded substrate that was placed at varying distance from the electrospray. MA particle with size range of 100–400 nm were produced by electrospray drying process. Characterization of particles by using X-ray diffractometry (XRD) and differential scanning calorimetry (DSC) show that particles formed into polymorph I. AIP Publishing LLC 2013 Conference or Workshop Item PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/57601/1/Nanoparticle%20preparation%20of%20mefenamic%20acid%20by%20electrospray%20drying.pdf Zolkepali, Nurul Karimah and Abu Bakar, Noor Fitrah and Naim, Mohd Nazli and Anuar, Nornizar and Abu Bakar, Mohd Rushdi (2013) Nanoparticle preparation of mefenamic acid by electrospray drying. In: 5th Nanoscience and Nanotechnology Symposium (NNS 2013), 23-25 Oct. 2013, Surabaya, Indonesia. (pp. 113-118). 10.1063/1.4866742 |
| spellingShingle | Zolkepali, Nurul Karimah Abu Bakar, Noor Fitrah Naim, Mohd Nazli Anuar, Nornizar Abu Bakar, Mohd Rushdi Nanoparticle preparation of mefenamic acid by electrospray drying |
| title | Nanoparticle preparation of mefenamic acid by electrospray drying |
| title_full | Nanoparticle preparation of mefenamic acid by electrospray drying |
| title_fullStr | Nanoparticle preparation of mefenamic acid by electrospray drying |
| title_full_unstemmed | Nanoparticle preparation of mefenamic acid by electrospray drying |
| title_short | Nanoparticle preparation of mefenamic acid by electrospray drying |
| title_sort | nanoparticle preparation of mefenamic acid by electrospray drying |
| url | http://psasir.upm.edu.my/id/eprint/57601/1/Nanoparticle%20preparation%20of%20mefenamic%20acid%20by%20electrospray%20drying.pdf |
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