The value of 18F-fluorodeoxyglucose-positron emission tomography/ computed tomography (18F- FDG PET/CT) in the staging and impact on the management of patients with nasopharyngeal carcinoma
This study sought to prospectively evaluate the influence of contrasted fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDGPET/CT) in the staging of and impact on the management plan for treatment in patients with nasopharyngeal carcinoma (NPC). A total of 14 his...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Universiti Putra Malaysia Press
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/57858/1/03%20JST%20Vol%2025%20%283%29%20July%202017_JST-0601-2016_pg687-696.pdf |
| _version_ | 1796976780055150592 |
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| author | Subha, Sethu Thakachy Ahmad Saad, Fathinul Fikri Nordin, Abdul Jalil Abu Bakar, Saraiza |
| author_facet | Subha, Sethu Thakachy Ahmad Saad, Fathinul Fikri Nordin, Abdul Jalil Abu Bakar, Saraiza |
| author_sort | Subha, Sethu Thakachy |
| collection | UPM |
| description | This study sought to prospectively evaluate the influence of contrasted fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDGPET/CT) in the staging of and impact on the management plan for treatment in patients with nasopharyngeal carcinoma (NPC). A total of 14 histologically proven NPC patients (mean age: 44.64±4.01years) were included in the study. These patients underwent contrasted Computed Tomography (CT) as well as 18F-FDGPET/CT imaging. Staging was based on the 7th edition of the American Joint Committee on Cancer Tumor Node Metastases (AJCC-TNM) recommendations. The oncologist was asked to prospectively assign a treatment plan for all patients being evaluated by CT and 18F-FDGPET/CT. The treatment plans were compared with the incremental information supplied by the FDG-PET/CT. The maximum standardised uptake value (SUVmax) and the widest dimension of the primary tumour, cervical lymph nodes size and the distant metastatic lesions were quantified on the co-registered PET/CT images by two experienced nuclear radiologists. The contrasted 18F-FDGPET/CT changed the management intent in nine patients (64.7%). A univariate analysis showed that there were significant correlations between SUVmax and the size of the metastatic lymph nodes (R2 =0.0761, p<0.01), lymph node volume (R2=0.695, p<0.01) and the T-stage (R2=0.647, p<0.01). Multiple linear regression analysis revealed the tumour SUVmax to be the independent predictor of the T-stage (adjusted R2=0.889, p<0.05). The SUVmax may potentially be a surrogate marker for the T-stage in the NPC patients. The use of the combined imaging modality, 18F-FDGPET/CT, substantially impacted on the management strategy for treatment of NPC patients. |
| first_indexed | 2024-03-06T09:30:39Z |
| format | Article |
| id | upm.eprints-57858 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:30:39Z |
| publishDate | 2017 |
| publisher | Universiti Putra Malaysia Press |
| record_format | dspace |
| spelling | upm.eprints-578582017-10-26T08:48:25Z http://psasir.upm.edu.my/id/eprint/57858/ The value of 18F-fluorodeoxyglucose-positron emission tomography/ computed tomography (18F- FDG PET/CT) in the staging and impact on the management of patients with nasopharyngeal carcinoma Subha, Sethu Thakachy Ahmad Saad, Fathinul Fikri Nordin, Abdul Jalil Abu Bakar, Saraiza This study sought to prospectively evaluate the influence of contrasted fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDGPET/CT) in the staging of and impact on the management plan for treatment in patients with nasopharyngeal carcinoma (NPC). A total of 14 histologically proven NPC patients (mean age: 44.64±4.01years) were included in the study. These patients underwent contrasted Computed Tomography (CT) as well as 18F-FDGPET/CT imaging. Staging was based on the 7th edition of the American Joint Committee on Cancer Tumor Node Metastases (AJCC-TNM) recommendations. The oncologist was asked to prospectively assign a treatment plan for all patients being evaluated by CT and 18F-FDGPET/CT. The treatment plans were compared with the incremental information supplied by the FDG-PET/CT. The maximum standardised uptake value (SUVmax) and the widest dimension of the primary tumour, cervical lymph nodes size and the distant metastatic lesions were quantified on the co-registered PET/CT images by two experienced nuclear radiologists. The contrasted 18F-FDGPET/CT changed the management intent in nine patients (64.7%). A univariate analysis showed that there were significant correlations between SUVmax and the size of the metastatic lymph nodes (R2 =0.0761, p<0.01), lymph node volume (R2=0.695, p<0.01) and the T-stage (R2=0.647, p<0.01). Multiple linear regression analysis revealed the tumour SUVmax to be the independent predictor of the T-stage (adjusted R2=0.889, p<0.05). The SUVmax may potentially be a surrogate marker for the T-stage in the NPC patients. The use of the combined imaging modality, 18F-FDGPET/CT, substantially impacted on the management strategy for treatment of NPC patients. Universiti Putra Malaysia Press 2017 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/57858/1/03%20JST%20Vol%2025%20%283%29%20July%202017_JST-0601-2016_pg687-696.pdf Subha, Sethu Thakachy and Ahmad Saad, Fathinul Fikri and Nordin, Abdul Jalil and Abu Bakar, Saraiza (2017) The value of 18F-fluorodeoxyglucose-positron emission tomography/ computed tomography (18F- FDG PET/CT) in the staging and impact on the management of patients with nasopharyngeal carcinoma. Pertanika Journal of Science & Technology, 25 (3). pp. 687-696. ISSN 0128-7680; ESSN: 2231-8526 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JST%20Vol.%2025%20(3)%20Jul.%202017/03%20JST%20Vol%2025%20(3)%20July%202017_JST-0601-2016_pg687-696.pdf |
| spellingShingle | Subha, Sethu Thakachy Ahmad Saad, Fathinul Fikri Nordin, Abdul Jalil Abu Bakar, Saraiza The value of 18F-fluorodeoxyglucose-positron emission tomography/ computed tomography (18F- FDG PET/CT) in the staging and impact on the management of patients with nasopharyngeal carcinoma |
| title | The value of 18F-fluorodeoxyglucose-positron emission tomography/ computed tomography (18F- FDG PET/CT) in the staging and impact on the management of patients with nasopharyngeal carcinoma |
| title_full | The value of 18F-fluorodeoxyglucose-positron emission tomography/ computed tomography (18F- FDG PET/CT) in the staging and impact on the management of patients with nasopharyngeal carcinoma |
| title_fullStr | The value of 18F-fluorodeoxyglucose-positron emission tomography/ computed tomography (18F- FDG PET/CT) in the staging and impact on the management of patients with nasopharyngeal carcinoma |
| title_full_unstemmed | The value of 18F-fluorodeoxyglucose-positron emission tomography/ computed tomography (18F- FDG PET/CT) in the staging and impact on the management of patients with nasopharyngeal carcinoma |
| title_short | The value of 18F-fluorodeoxyglucose-positron emission tomography/ computed tomography (18F- FDG PET/CT) in the staging and impact on the management of patients with nasopharyngeal carcinoma |
| title_sort | value of 18f fluorodeoxyglucose positron emission tomography computed tomography 18f fdg pet ct in the staging and impact on the management of patients with nasopharyngeal carcinoma |
| url | http://psasir.upm.edu.my/id/eprint/57858/1/03%20JST%20Vol%2025%20%283%29%20July%202017_JST-0601-2016_pg687-696.pdf |
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