Horizontal gene transfer: a vehicle for the dissemination of resistance and virulence determinants during colonization and disease
The successful in vivo horizontal transfer of mobile genetic elements carrying resistance and virulence determinants have contributed immensely to a global dissemination of virulent and multi-drug resistant pathogens. In addition, the pathogenesis of MRSA infection is enhanced via initial colonizati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Universiti Putra Malaysia Press
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/58636/1/Horizontal%20gene%20transfer.pdf |
| _version_ | 1825931848881012736 |
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| author | Bitrus, Asinamai Athliamai Zakaria, Zunita Bejo, Siti Khairani Othman, Siti Sarah |
| author_facet | Bitrus, Asinamai Athliamai Zakaria, Zunita Bejo, Siti Khairani Othman, Siti Sarah |
| author_sort | Bitrus, Asinamai Athliamai |
| collection | UPM |
| description | The successful in vivo horizontal transfer of mobile genetic elements carrying resistance and virulence determinants have contributed immensely to a global dissemination of virulent and multi-drug resistant pathogens. In addition, the pathogenesis of MRSA infection is enhanced via initial colonization of the skin through the component of the microbial surface antigen recognizing adhesive matrix molecules and by their ability to evade host immune response. Furthermore, it was also observed that the genetic diversity of pathogenic MRSA is due to its’ ability to rapidly acquire resistance and virulence determinants. A characteristic feature that made it one of the most important nosocomial pathogen worldwide. Similarly, the expression of virulence gene in MRSA has been observed to be regulated by the accessory gene regulator system (agr). These system is made up of a series of genes whose product build up quorum-sensing regulatory mechanisms that is growth dependent. In addition, at a certain growth stage, the agr systems triggers a pronounced changes in the expression of genes called the quorum sensing. The findings of this review affirms the importance of horizontal gene transfer in the dissemination of resistance and virulence determinants and as well as the genetic diversity of MRSA. |
| first_indexed | 2024-03-06T09:32:58Z |
| format | Article |
| id | upm.eprints-58636 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:32:58Z |
| publishDate | 2017 |
| publisher | Universiti Putra Malaysia Press |
| record_format | dspace |
| spelling | upm.eprints-586362018-01-24T07:41:00Z http://psasir.upm.edu.my/id/eprint/58636/ Horizontal gene transfer: a vehicle for the dissemination of resistance and virulence determinants during colonization and disease Bitrus, Asinamai Athliamai Zakaria, Zunita Bejo, Siti Khairani Othman, Siti Sarah The successful in vivo horizontal transfer of mobile genetic elements carrying resistance and virulence determinants have contributed immensely to a global dissemination of virulent and multi-drug resistant pathogens. In addition, the pathogenesis of MRSA infection is enhanced via initial colonization of the skin through the component of the microbial surface antigen recognizing adhesive matrix molecules and by their ability to evade host immune response. Furthermore, it was also observed that the genetic diversity of pathogenic MRSA is due to its’ ability to rapidly acquire resistance and virulence determinants. A characteristic feature that made it one of the most important nosocomial pathogen worldwide. Similarly, the expression of virulence gene in MRSA has been observed to be regulated by the accessory gene regulator system (agr). These system is made up of a series of genes whose product build up quorum-sensing regulatory mechanisms that is growth dependent. In addition, at a certain growth stage, the agr systems triggers a pronounced changes in the expression of genes called the quorum sensing. The findings of this review affirms the importance of horizontal gene transfer in the dissemination of resistance and virulence determinants and as well as the genetic diversity of MRSA. Universiti Putra Malaysia Press 2017 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/58636/1/Horizontal%20gene%20transfer.pdf Bitrus, Asinamai Athliamai and Zakaria, Zunita and Bejo, Siti Khairani and Othman, Siti Sarah (2017) Horizontal gene transfer: a vehicle for the dissemination of resistance and virulence determinants during colonization and disease. Pertanika Journal of Scholarly Research Reviews, 3 (3). pp. 51-60. ISSN 2462-2028 http://pjsrr.upm.edu.my/index.php/pjsrr/article/view/55 |
| spellingShingle | Bitrus, Asinamai Athliamai Zakaria, Zunita Bejo, Siti Khairani Othman, Siti Sarah Horizontal gene transfer: a vehicle for the dissemination of resistance and virulence determinants during colonization and disease |
| title | Horizontal gene transfer: a vehicle for the dissemination of resistance and virulence determinants during colonization and disease |
| title_full | Horizontal gene transfer: a vehicle for the dissemination of resistance and virulence determinants during colonization and disease |
| title_fullStr | Horizontal gene transfer: a vehicle for the dissemination of resistance and virulence determinants during colonization and disease |
| title_full_unstemmed | Horizontal gene transfer: a vehicle for the dissemination of resistance and virulence determinants during colonization and disease |
| title_short | Horizontal gene transfer: a vehicle for the dissemination of resistance and virulence determinants during colonization and disease |
| title_sort | horizontal gene transfer a vehicle for the dissemination of resistance and virulence determinants during colonization and disease |
| url | http://psasir.upm.edu.my/id/eprint/58636/1/Horizontal%20gene%20transfer.pdf |
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