Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: possible involvement of the opioid system
Neuropathic pain arises from the injury of nervous system. The condition is extremely difficult to be treated due to the ineffectiveness and presence of various adverse effects of the currently available drugs. In the present study, we investigated the antiallodynic and antihyperlagesic properties o...
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| Format: | Article |
| Language: | English |
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Elsevier
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/61051/1/Cardamonin%20attenuates%20hyperalgesia%20and%20allodynia%20in%20a%20mouse%20model%20of%20chronic%20constriction%20injury-induced%20neuropathic%20pain%20possible%20involvement%20of%20the%20opioid%20system.pdf |
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| author | Sambasevam, Yogesvari Omar Farouk, Ahmad Akira Tengku Mohamad, Tengku Azam Shah Sulaiman, Mohd Roslan Bharatham, B. Hemabarathy Perimal, Enoch Kumar |
| author_facet | Sambasevam, Yogesvari Omar Farouk, Ahmad Akira Tengku Mohamad, Tengku Azam Shah Sulaiman, Mohd Roslan Bharatham, B. Hemabarathy Perimal, Enoch Kumar |
| author_sort | Sambasevam, Yogesvari |
| collection | UPM |
| description | Neuropathic pain arises from the injury of nervous system. The condition is extremely difficult to be treated due to the ineffectiveness and presence of various adverse effects of the currently available drugs. In the present study, we investigated the antiallodynic and antihyperlagesic properties of cardamonin, a naturally occurring chalcone in chronic constriction injury (CCI)-induced neuropathic pain mice model. Our findings showed that single and repeated dose of intra-peritoneal administration of cardamonin (3, 10, 30 mg/kg) significantly inhibited (P<0.001) the chronic constriction injury-induced neuropathic pain using the Hargreaves plantar test, Randall-Selitto analgesiometer test, dynamic plantar anesthesiometer test and the cold plate test in comparison with the positive control drug used (amitriptyline hydrochloride, 20 mg/kg, i.p.). Pre-treatment with naloxone hydrochloride (1 mg/kg, i.p.) and naloxone methiodide (1 mg/kg, s.c) significantly reversed the antiallodynic and antihyperalgesic effects of cardamonin in dynamic plantar anesthesiometer test and Hargreaves plantar test, respectively. In conclusion, the current findings demonstrated novel antiallodynic and antihyperalgesic effects of cardamonin through the activation of the opioidergic system both peripherally and centrally and may prove to be a potent lead compound for the development of neuropathic pain drugs in the future. |
| first_indexed | 2024-03-06T09:39:33Z |
| format | Article |
| id | upm.eprints-61051 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:39:33Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-610512019-01-31T01:55:44Z http://psasir.upm.edu.my/id/eprint/61051/ Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: possible involvement of the opioid system Sambasevam, Yogesvari Omar Farouk, Ahmad Akira Tengku Mohamad, Tengku Azam Shah Sulaiman, Mohd Roslan Bharatham, B. Hemabarathy Perimal, Enoch Kumar Neuropathic pain arises from the injury of nervous system. The condition is extremely difficult to be treated due to the ineffectiveness and presence of various adverse effects of the currently available drugs. In the present study, we investigated the antiallodynic and antihyperlagesic properties of cardamonin, a naturally occurring chalcone in chronic constriction injury (CCI)-induced neuropathic pain mice model. Our findings showed that single and repeated dose of intra-peritoneal administration of cardamonin (3, 10, 30 mg/kg) significantly inhibited (P<0.001) the chronic constriction injury-induced neuropathic pain using the Hargreaves plantar test, Randall-Selitto analgesiometer test, dynamic plantar anesthesiometer test and the cold plate test in comparison with the positive control drug used (amitriptyline hydrochloride, 20 mg/kg, i.p.). Pre-treatment with naloxone hydrochloride (1 mg/kg, i.p.) and naloxone methiodide (1 mg/kg, s.c) significantly reversed the antiallodynic and antihyperalgesic effects of cardamonin in dynamic plantar anesthesiometer test and Hargreaves plantar test, respectively. In conclusion, the current findings demonstrated novel antiallodynic and antihyperalgesic effects of cardamonin through the activation of the opioidergic system both peripherally and centrally and may prove to be a potent lead compound for the development of neuropathic pain drugs in the future. Elsevier 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/61051/1/Cardamonin%20attenuates%20hyperalgesia%20and%20allodynia%20in%20a%20mouse%20model%20of%20chronic%20constriction%20injury-induced%20neuropathic%20pain%20possible%20involvement%20of%20the%20opioid%20system.pdf Sambasevam, Yogesvari and Omar Farouk, Ahmad Akira and Tengku Mohamad, Tengku Azam Shah and Sulaiman, Mohd Roslan and Bharatham, B. Hemabarathy and Perimal, Enoch Kumar (2016) Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: possible involvement of the opioid system. European Journal of Pharmacology, 796. pp. 32-38. ISSN 0014-2999; ESSN: 1879-0712 10.1016/j.ejphar.2016.12.020 |
| spellingShingle | Sambasevam, Yogesvari Omar Farouk, Ahmad Akira Tengku Mohamad, Tengku Azam Shah Sulaiman, Mohd Roslan Bharatham, B. Hemabarathy Perimal, Enoch Kumar Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: possible involvement of the opioid system |
| title | Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: possible involvement of the opioid system |
| title_full | Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: possible involvement of the opioid system |
| title_fullStr | Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: possible involvement of the opioid system |
| title_full_unstemmed | Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: possible involvement of the opioid system |
| title_short | Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: possible involvement of the opioid system |
| title_sort | cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury induced neuropathic pain possible involvement of the opioid system |
| url | http://psasir.upm.edu.my/id/eprint/61051/1/Cardamonin%20attenuates%20hyperalgesia%20and%20allodynia%20in%20a%20mouse%20model%20of%20chronic%20constriction%20injury-induced%20neuropathic%20pain%20possible%20involvement%20of%20the%20opioid%20system.pdf |
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