Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge
Creutzfeldt-Jakob disease (CJD) is a rare disorder that presents with a myriad of symptoms. Early features may include pyramidal and cerebellar signs with very vague history of dementia. This makes diagnosis particularly challenging; especially when a different diagnosis is more common. Unavailabili...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Pakistan Medical Association
2017
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/61247/1/CJD.pdf |
| _version_ | 1796977436514058240 |
|---|---|
| author | Abdul Rashid, Anna Misya'il Md Noh, Mohamad Syafeeq Faeez Hoo, Fan Kee Wan Sulaiman, Wan Aliaa Inche Mat, Liyana Najwa Basri, Hamidon |
| author_facet | Abdul Rashid, Anna Misya'il Md Noh, Mohamad Syafeeq Faeez Hoo, Fan Kee Wan Sulaiman, Wan Aliaa Inche Mat, Liyana Najwa Basri, Hamidon |
| author_sort | Abdul Rashid, Anna Misya'il |
| collection | UPM |
| description | Creutzfeldt-Jakob disease (CJD) is a rare disorder that presents with a myriad of symptoms. Early features may include pyramidal and cerebellar signs with very vague history of dementia. This makes diagnosis particularly challenging; especially when a different diagnosis is more common. Unavailability of laboratory testing in most centers also limits the diagnosis. Newer literature agrees on the reliability of neuroimaging, namely magnetic resonance imaging (MRI) and its role in providing a clear diagnosis in CJD. We report a patient presenting with dementia, pyramidal symptoms and later had myoclonic jerks. He refused lumbar puncture, and electroencephalogram (EEG) changes were not typical of CJD. Only on MRI were we able to prove his diagnosis as workup for alternative diagnoses were negative. Though there is no curative intervention, supportive treatment proves of utmost importance during the course of illness. |
| first_indexed | 2024-03-06T09:40:06Z |
| format | Article |
| id | upm.eprints-61247 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:40:06Z |
| publishDate | 2017 |
| publisher | Pakistan Medical Association |
| record_format | dspace |
| spelling | upm.eprints-612472021-07-17T22:59:27Z http://psasir.upm.edu.my/id/eprint/61247/ Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge Abdul Rashid, Anna Misya'il Md Noh, Mohamad Syafeeq Faeez Hoo, Fan Kee Wan Sulaiman, Wan Aliaa Inche Mat, Liyana Najwa Basri, Hamidon Creutzfeldt-Jakob disease (CJD) is a rare disorder that presents with a myriad of symptoms. Early features may include pyramidal and cerebellar signs with very vague history of dementia. This makes diagnosis particularly challenging; especially when a different diagnosis is more common. Unavailability of laboratory testing in most centers also limits the diagnosis. Newer literature agrees on the reliability of neuroimaging, namely magnetic resonance imaging (MRI) and its role in providing a clear diagnosis in CJD. We report a patient presenting with dementia, pyramidal symptoms and later had myoclonic jerks. He refused lumbar puncture, and electroencephalogram (EEG) changes were not typical of CJD. Only on MRI were we able to prove his diagnosis as workup for alternative diagnoses were negative. Though there is no curative intervention, supportive treatment proves of utmost importance during the course of illness. Pakistan Medical Association 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/61247/1/CJD.pdf Abdul Rashid, Anna Misya'il and Md Noh, Mohamad Syafeeq Faeez and Hoo, Fan Kee and Wan Sulaiman, Wan Aliaa and Inche Mat, Liyana Najwa and Basri, Hamidon (2017) Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge. Rawal Medical Journal, 42 (4). 587 - 589. ISSN 0303-5212 https://www.bibliomed.org/?mno=258700 |
| spellingShingle | Abdul Rashid, Anna Misya'il Md Noh, Mohamad Syafeeq Faeez Hoo, Fan Kee Wan Sulaiman, Wan Aliaa Inche Mat, Liyana Najwa Basri, Hamidon Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge |
| title | Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge |
| title_full | Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge |
| title_fullStr | Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge |
| title_full_unstemmed | Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge |
| title_short | Creutzfeldt-Jakob Disease (CJD) in Southeast Asia: a diagnostic challenge |
| title_sort | creutzfeldt jakob disease cjd in southeast asia a diagnostic challenge |
| url | http://psasir.upm.edu.my/id/eprint/61247/1/CJD.pdf |
| work_keys_str_mv | AT abdulrashidannamisyail creutzfeldtjakobdiseasecjdinsoutheastasiaadiagnosticchallenge AT mdnohmohamadsyafeeqfaeez creutzfeldtjakobdiseasecjdinsoutheastasiaadiagnosticchallenge AT hoofankee creutzfeldtjakobdiseasecjdinsoutheastasiaadiagnosticchallenge AT wansulaimanwanaliaa creutzfeldtjakobdiseasecjdinsoutheastasiaadiagnosticchallenge AT inchematliyananajwa creutzfeldtjakobdiseasecjdinsoutheastasiaadiagnosticchallenge AT basrihamidon creutzfeldtjakobdiseasecjdinsoutheastasiaadiagnosticchallenge |