Crude extracts, flavokawain B and alpinetin compounds from the rhizome of Alpinia mutica induce cell death via UCK2 enzyme inhibition and in turn reduce 18S rRNA biosynthesis in HT-29 cells
Uridine-cytidine kinase 2 is an enzyme that is overexpressed in abnormal cell growth and its implication is considered a hallmark of cancer. Due to the selective expression of UCK2 in cancer cells, a selective inhibition of this key enzyme necessitates the discovery of its potential inhibitors for c...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/61259/1/Crude%20extracts%2C%20flavokawain%20B%20and%20alpinetin%20compounds%20from%20the%20rhizome%20of%20Alpinia%20mutica%20induce%20cell%20death%20via%20UCK2%20enzyme%20inhibition%20and%20in%20turn%20reduce%2018S%20rRNA%20biosynthesis%20in%20HT-29%20cells.pdf |