Determination of the 99th percentile upper reference limit for highsensitivity cardiac troponin I in Malaysian population
Introduction of high-sensitivity cardiac troponin I (hscTn I) assays for routine clinical use in Malaysia requires determination of the 99th percentile upper reference limit (URL) for each assay to suit local context. Hence, this study aimed to determine the 99th percentile URL for hscTn I in the Ma...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Malaysian Society of Pathologists
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/61431/1/Determination%20of%20the%2099th%20percentile%20upper%20reference%20limit%20for%20high-sensitivity%20cardiac%20.pdf |
| _version_ | 1825932336041033728 |
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| author | Lim, Say Min Chellappah Thambiah, Subashini Zahari Sham, Siti Yazmin Omar, Roslina Hambali, Zarida Samsudin, Intan Nureslyna |
| author_facet | Lim, Say Min Chellappah Thambiah, Subashini Zahari Sham, Siti Yazmin Omar, Roslina Hambali, Zarida Samsudin, Intan Nureslyna |
| author_sort | Lim, Say Min |
| collection | UPM |
| description | Introduction of high-sensitivity cardiac troponin I (hscTn I) assays for routine clinical use in Malaysia requires determination of the 99th percentile upper reference limit (URL) for each assay to suit local context. Hence, this study aimed to determine the 99th percentile URL for hscTn I in the Malaysian population. A total of 250 (120 males and 130 females) healthy Malaysian blood donors aged 18 to 60 years old were recruited. Blood samples for hscTn I were measured using Abbott Diagnostics hscTn I assay on Architect i2000sr analyser. The 99th percentile was calculated using a non-parametric method and gender specific results were compared. The 99th percentile URL for hscTn I for the overall population was 23.7 ng/L, with gender specific values being 29.9 ng/L and 18.6 ng/L for male and female, respectively. Females had significantly lower hscTn I compared to males. This study confirms the use of gender specific 99th percentile URL for hscTn I for clinical use in a multi-ethnic Malaysian population. |
| first_indexed | 2024-03-06T09:40:28Z |
| format | Article |
| id | upm.eprints-61431 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:40:28Z |
| publishDate | 2017 |
| publisher | Malaysian Society of Pathologists |
| record_format | dspace |
| spelling | upm.eprints-614312018-05-23T01:41:16Z http://psasir.upm.edu.my/id/eprint/61431/ Determination of the 99th percentile upper reference limit for highsensitivity cardiac troponin I in Malaysian population Lim, Say Min Chellappah Thambiah, Subashini Zahari Sham, Siti Yazmin Omar, Roslina Hambali, Zarida Samsudin, Intan Nureslyna Introduction of high-sensitivity cardiac troponin I (hscTn I) assays for routine clinical use in Malaysia requires determination of the 99th percentile upper reference limit (URL) for each assay to suit local context. Hence, this study aimed to determine the 99th percentile URL for hscTn I in the Malaysian population. A total of 250 (120 males and 130 females) healthy Malaysian blood donors aged 18 to 60 years old were recruited. Blood samples for hscTn I were measured using Abbott Diagnostics hscTn I assay on Architect i2000sr analyser. The 99th percentile was calculated using a non-parametric method and gender specific results were compared. The 99th percentile URL for hscTn I for the overall population was 23.7 ng/L, with gender specific values being 29.9 ng/L and 18.6 ng/L for male and female, respectively. Females had significantly lower hscTn I compared to males. This study confirms the use of gender specific 99th percentile URL for hscTn I for clinical use in a multi-ethnic Malaysian population. Malaysian Society of Pathologists 2017 Article NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/61431/1/Determination%20of%20the%2099th%20percentile%20upper%20reference%20limit%20for%20high-sensitivity%20cardiac%20.pdf Lim, Say Min and Chellappah Thambiah, Subashini and Zahari Sham, Siti Yazmin and Omar, Roslina and Hambali, Zarida and Samsudin, Intan Nureslyna (2017) Determination of the 99th percentile upper reference limit for highsensitivity cardiac troponin I in Malaysian population. The Malaysian Journal of Pathology, 39 (2). 135 - 140. ISSN 0126-8635 http://www.mjpath.org.my/2017/v39n2/index.php |
| spellingShingle | Lim, Say Min Chellappah Thambiah, Subashini Zahari Sham, Siti Yazmin Omar, Roslina Hambali, Zarida Samsudin, Intan Nureslyna Determination of the 99th percentile upper reference limit for highsensitivity cardiac troponin I in Malaysian population |
| title | Determination of the 99th percentile upper reference limit for highsensitivity cardiac troponin I in Malaysian population |
| title_full | Determination of the 99th percentile upper reference limit for highsensitivity cardiac troponin I in Malaysian population |
| title_fullStr | Determination of the 99th percentile upper reference limit for highsensitivity cardiac troponin I in Malaysian population |
| title_full_unstemmed | Determination of the 99th percentile upper reference limit for highsensitivity cardiac troponin I in Malaysian population |
| title_short | Determination of the 99th percentile upper reference limit for highsensitivity cardiac troponin I in Malaysian population |
| title_sort | determination of the 99th percentile upper reference limit for highsensitivity cardiac troponin i in malaysian population |
| url | http://psasir.upm.edu.my/id/eprint/61431/1/Determination%20of%20the%2099th%20percentile%20upper%20reference%20limit%20for%20high-sensitivity%20cardiac%20.pdf |
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