Directly observed therapy for clozapine with concomitant methadone prescription: a method for improving adherence and outcome
A young male presented with many years of delusions and hallucinations, with concurrent heroin use and subsequent amphetamine uses. There were no depressive or manic symptoms and psychotic symptoms prior to the amphetamine use. After the trials of two atypical antipsychotics and later clozapine due...
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| Format: | Article |
| Language: | English |
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BMJ Group
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/61490/1/Directly%20observed%20therapy%20for%20clozapine%20with%20concomitant%20methadone%20prescription%20a%20method%20for%20improving%20adherence%20and%20outcome.pdf |
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| author | Pang, Nicholas Tze Ping Mohamad Isa, Mohd Fadzli Suarn Singh, Vikram Masiran, Ruziana |
| author_facet | Pang, Nicholas Tze Ping Mohamad Isa, Mohd Fadzli Suarn Singh, Vikram Masiran, Ruziana |
| author_sort | Pang, Nicholas Tze Ping |
| collection | UPM |
| description | A young male presented with many years of delusions and hallucinations, with concurrent heroin use and subsequent amphetamine uses. There were no depressive or manic symptoms and psychotic symptoms prior to the amphetamine use. After the trials of two atypical antipsychotics and later clozapine due to treatment resistance, adherence and functionality were poor and there was still persistent drug use. As a result, a long acting injectable adjunct was commenced, but only minimal effects were observed. However after initiation of directly observed treatment of clozapine with methadone, there has been functional and clinical response and drug use has ceased. |
| first_indexed | 2024-03-06T09:40:37Z |
| format | Article |
| id | upm.eprints-61490 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:40:37Z |
| publishDate | 2017 |
| publisher | BMJ Group |
| record_format | dspace |
| spelling | upm.eprints-614902022-03-30T04:46:31Z http://psasir.upm.edu.my/id/eprint/61490/ Directly observed therapy for clozapine with concomitant methadone prescription: a method for improving adherence and outcome Pang, Nicholas Tze Ping Mohamad Isa, Mohd Fadzli Suarn Singh, Vikram Masiran, Ruziana A young male presented with many years of delusions and hallucinations, with concurrent heroin use and subsequent amphetamine uses. There were no depressive or manic symptoms and psychotic symptoms prior to the amphetamine use. After the trials of two atypical antipsychotics and later clozapine due to treatment resistance, adherence and functionality were poor and there was still persistent drug use. As a result, a long acting injectable adjunct was commenced, but only minimal effects were observed. However after initiation of directly observed treatment of clozapine with methadone, there has been functional and clinical response and drug use has ceased. BMJ Group 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/61490/1/Directly%20observed%20therapy%20for%20clozapine%20with%20concomitant%20methadone%20prescription%20a%20method%20for%20improving%20adherence%20and%20outcome.pdf Pang, Nicholas Tze Ping and Mohamad Isa, Mohd Fadzli and Suarn Singh, Vikram and Masiran, Ruziana (2017) Directly observed therapy for clozapine with concomitant methadone prescription: a method for improving adherence and outcome. BMJ Case Reports, 2017. pp. 1-3. ISSN 1757-790X https://casereports.bmj.com/content/2017/bcr-2017-221048.long 10.1136/bcr-2017-221048 |
| spellingShingle | Pang, Nicholas Tze Ping Mohamad Isa, Mohd Fadzli Suarn Singh, Vikram Masiran, Ruziana Directly observed therapy for clozapine with concomitant methadone prescription: a method for improving adherence and outcome |
| title | Directly observed therapy for clozapine with concomitant methadone prescription: a method for improving adherence and outcome |
| title_full | Directly observed therapy for clozapine with concomitant methadone prescription: a method for improving adherence and outcome |
| title_fullStr | Directly observed therapy for clozapine with concomitant methadone prescription: a method for improving adherence and outcome |
| title_full_unstemmed | Directly observed therapy for clozapine with concomitant methadone prescription: a method for improving adherence and outcome |
| title_short | Directly observed therapy for clozapine with concomitant methadone prescription: a method for improving adherence and outcome |
| title_sort | directly observed therapy for clozapine with concomitant methadone prescription a method for improving adherence and outcome |
| url | http://psasir.upm.edu.my/id/eprint/61490/1/Directly%20observed%20therapy%20for%20clozapine%20with%20concomitant%20methadone%20prescription%20a%20method%20for%20improving%20adherence%20and%20outcome.pdf |
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