Effect of dietary macronutrients on aflatoxicosis: a mini-review
Aflatoxin is a toxin produced by Aspergillus species of fungi. The main route of aflatoxin exposure is through the diet. Indeed, long-term aflatoxin exposure is linked to the development of hepatocellular carcinoma (HCC). Aflatoxin causes aflatoxicosis, which can be affected by several factors and i...
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| Format: | Article |
| Language: | English |
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John Wiley & Sons Ltd.
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/61554/1/Effect%20of%20dietary%20macronutrients%20on%20aflatoxicosis%2C%20a%20mini-review.pdf |
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| author | Zainuddin, Nurul Adilah Sabran, Mohd Redzwan |
| author_facet | Zainuddin, Nurul Adilah Sabran, Mohd Redzwan |
| author_sort | Zainuddin, Nurul Adilah |
| collection | UPM |
| description | Aflatoxin is a toxin produced by Aspergillus species of fungi. The main route of aflatoxin exposure is through the diet. Indeed, long-term aflatoxin exposure is linked to the development of hepatocellular carcinoma (HCC). Aflatoxin causes aflatoxicosis, which can be affected by several factors and is prevalent in many developing Asian and African countries. This mini-review discusses the effects of carbohydrate, fat and protein on aflatoxicosis based on findings from animal and human studies. It was found that high carbohydrate intake enhanced aflatoxicosis occurrence, while low ingestion of carbohydrate with caloric restriction slowed the symptoms associated with aflatoxicosis. Additionally, diets with low protein content worsened the symptoms related to HCC due to aflatoxin exposure. Nevertheless, a study reported that a high-protein diet favored detoxification of aflatoxin in vivo. There were also conflicting results on the influence of dietary fat, as high ingestion of fat enhanced aflatoxicosis development as compared with a low-fat diet. Moreover, the type of fat also plays a significant role in influencing aflatoxin toxicity. In regard to food safety, understanding the influence of macronutrients toward the progression of aflatoxicosis can improve preventive measures against human and animal exposure to aflatoxin. |
| first_indexed | 2024-03-06T09:40:45Z |
| format | Article |
| id | upm.eprints-61554 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:40:45Z |
| publishDate | 2017 |
| publisher | John Wiley & Sons Ltd. |
| record_format | dspace |
| spelling | upm.eprints-615542022-05-24T02:50:50Z http://psasir.upm.edu.my/id/eprint/61554/ Effect of dietary macronutrients on aflatoxicosis: a mini-review Zainuddin, Nurul Adilah Sabran, Mohd Redzwan Aflatoxin is a toxin produced by Aspergillus species of fungi. The main route of aflatoxin exposure is through the diet. Indeed, long-term aflatoxin exposure is linked to the development of hepatocellular carcinoma (HCC). Aflatoxin causes aflatoxicosis, which can be affected by several factors and is prevalent in many developing Asian and African countries. This mini-review discusses the effects of carbohydrate, fat and protein on aflatoxicosis based on findings from animal and human studies. It was found that high carbohydrate intake enhanced aflatoxicosis occurrence, while low ingestion of carbohydrate with caloric restriction slowed the symptoms associated with aflatoxicosis. Additionally, diets with low protein content worsened the symptoms related to HCC due to aflatoxin exposure. Nevertheless, a study reported that a high-protein diet favored detoxification of aflatoxin in vivo. There were also conflicting results on the influence of dietary fat, as high ingestion of fat enhanced aflatoxicosis development as compared with a low-fat diet. Moreover, the type of fat also plays a significant role in influencing aflatoxin toxicity. In regard to food safety, understanding the influence of macronutrients toward the progression of aflatoxicosis can improve preventive measures against human and animal exposure to aflatoxin. John Wiley & Sons Ltd. 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/61554/1/Effect%20of%20dietary%20macronutrients%20on%20aflatoxicosis%2C%20a%20mini-review.pdf Zainuddin, Nurul Adilah and Sabran, Mohd Redzwan (2017) Effect of dietary macronutrients on aflatoxicosis: a mini-review. Journal of Science and Food Agriculture, 97 (8). pp. 2277-2281. ISSN 0022-5142; ESSN: 1097-0010 https://onlinelibrary.wiley.com/doi/10.1002/jsfa.8234 10.1002/jsfa.8234 |
| spellingShingle | Zainuddin, Nurul Adilah Sabran, Mohd Redzwan Effect of dietary macronutrients on aflatoxicosis: a mini-review |
| title | Effect of dietary macronutrients on aflatoxicosis: a mini-review |
| title_full | Effect of dietary macronutrients on aflatoxicosis: a mini-review |
| title_fullStr | Effect of dietary macronutrients on aflatoxicosis: a mini-review |
| title_full_unstemmed | Effect of dietary macronutrients on aflatoxicosis: a mini-review |
| title_short | Effect of dietary macronutrients on aflatoxicosis: a mini-review |
| title_sort | effect of dietary macronutrients on aflatoxicosis a mini review |
| url | http://psasir.upm.edu.my/id/eprint/61554/1/Effect%20of%20dietary%20macronutrients%20on%20aflatoxicosis%2C%20a%20mini-review.pdf |
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