Obesity and Risk of Colorectal Adenomatous Polyps: a Case-Control Study in Hospital Kuala Lumpur
Colorectal adenomas are precursor lesions of colorectal cancer. Several studies have proposed that obesity is a risk factor for colorectal adenoma. This case-control study examined the relationship between body mass index (BMI), waist circumference, waistto-hip ratio (WHR), body fat percentage and c...
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| Format: | Article |
| Language: | English English |
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Nutrition Society of Malaysia
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/6189/1/vol_15_%281%29.pdf |
| _version_ | 1796967115148754944 |
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| author | Ramadas, Amutha Hambali, Zarida Alif Gul, Yunus Gul Jabal, Mohd Faizal Kandiah, Marlini |
| author_facet | Ramadas, Amutha Hambali, Zarida Alif Gul, Yunus Gul Jabal, Mohd Faizal Kandiah, Marlini |
| author_sort | Ramadas, Amutha |
| collection | UPM |
| description | Colorectal adenomas are precursor lesions of colorectal cancer. Several studies have proposed that obesity is a risk factor for colorectal adenoma. This case-control study examined the relationship between body mass index (BMI), waist circumference, waistto-hip ratio (WHR), body fat percentage and colorectal adenomatous polyps (CRA) in patients who have had a colonoscopy at the Hospital Kuala Lumpur (HKL). Fifty-nine patients (42 males and 17 females) positively identified as having CRA and 59 polypfree subjects were recruited as controls (33 males and 26 females). A pre-tested questionnaire was used to collect socio-economic information, while anthropometric measurements were determined directly by established methods. The mean BMI of female case subjects was significantly higher than control females (25.63 + 4.87 kg/m2 vs. 23.86 + 3.70 kg/m2, p<0.05) but the difference in BMI was not significant in men. The mean WHR of male subjects was significantly higher in the case group (0.92 + 0.07 vs. 0.90 + 0.06, p<0.05). After adjusting for confounders, waist circumference was the only indicator that was found to significantly increase the risk for CRA in women (OR = 6.349, 95% CI = 1.063 � 37.919). Higher BMI, WHR and body fat percentage showed a non-significant risk in female subjects. In men, none of the obesity indicators were found to be significant risk factors for CRA. These findings suggest that abdominal obesity may be a contributing factor to CRA risk particularly in women. A prospective study is needed to confirm the role of obesity in the development of CRA in Malaysians.
A1, Kandiah M2, H3, & JA4
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| first_indexed | 2024-03-06T07:09:11Z |
| format | Article |
| id | upm.eprints-6189 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:09:11Z |
| publishDate | 2009 |
| publisher | Nutrition Society of Malaysia |
| record_format | dspace |
| spelling | upm.eprints-61892013-05-27T07:27:47Z http://psasir.upm.edu.my/id/eprint/6189/ Obesity and Risk of Colorectal Adenomatous Polyps: a Case-Control Study in Hospital Kuala Lumpur Ramadas, Amutha Hambali, Zarida Alif Gul, Yunus Gul Jabal, Mohd Faizal Kandiah, Marlini Colorectal adenomas are precursor lesions of colorectal cancer. Several studies have proposed that obesity is a risk factor for colorectal adenoma. This case-control study examined the relationship between body mass index (BMI), waist circumference, waistto-hip ratio (WHR), body fat percentage and colorectal adenomatous polyps (CRA) in patients who have had a colonoscopy at the Hospital Kuala Lumpur (HKL). Fifty-nine patients (42 males and 17 females) positively identified as having CRA and 59 polypfree subjects were recruited as controls (33 males and 26 females). A pre-tested questionnaire was used to collect socio-economic information, while anthropometric measurements were determined directly by established methods. The mean BMI of female case subjects was significantly higher than control females (25.63 + 4.87 kg/m2 vs. 23.86 + 3.70 kg/m2, p<0.05) but the difference in BMI was not significant in men. The mean WHR of male subjects was significantly higher in the case group (0.92 + 0.07 vs. 0.90 + 0.06, p<0.05). After adjusting for confounders, waist circumference was the only indicator that was found to significantly increase the risk for CRA in women (OR = 6.349, 95% CI = 1.063 � 37.919). Higher BMI, WHR and body fat percentage showed a non-significant risk in female subjects. In men, none of the obesity indicators were found to be significant risk factors for CRA. These findings suggest that abdominal obesity may be a contributing factor to CRA risk particularly in women. A prospective study is needed to confirm the role of obesity in the development of CRA in Malaysians. A1, Kandiah M2, H3, & JA4 Nutrition Society of Malaysia 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/6189/1/vol_15_%281%29.pdf Ramadas, Amutha and Hambali, Zarida and Alif Gul, Yunus Gul and Jabal, Mohd Faizal and Kandiah, Marlini (2009) Obesity and Risk of Colorectal Adenomatous Polyps: a Case-Control Study in Hospital Kuala Lumpur. Malaysian Journal of Nutrition, 15 (1). pp. 2-10. ISSN 1394-035X English |
| spellingShingle | Ramadas, Amutha Hambali, Zarida Alif Gul, Yunus Gul Jabal, Mohd Faizal Kandiah, Marlini Obesity and Risk of Colorectal Adenomatous Polyps: a Case-Control Study in Hospital Kuala Lumpur |
| title | Obesity and Risk of Colorectal Adenomatous Polyps: a Case-Control Study in Hospital Kuala Lumpur
|
| title_full | Obesity and Risk of Colorectal Adenomatous Polyps: a Case-Control Study in Hospital Kuala Lumpur
|
| title_fullStr | Obesity and Risk of Colorectal Adenomatous Polyps: a Case-Control Study in Hospital Kuala Lumpur
|
| title_full_unstemmed | Obesity and Risk of Colorectal Adenomatous Polyps: a Case-Control Study in Hospital Kuala Lumpur
|
| title_short | Obesity and Risk of Colorectal Adenomatous Polyps: a Case-Control Study in Hospital Kuala Lumpur
|
| title_sort | obesity and risk of colorectal adenomatous polyps a case control study in hospital kuala lumpur |
| url | http://psasir.upm.edu.my/id/eprint/6189/1/vol_15_%281%29.pdf |
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