Gadolinium-based layered double hydroxide and graphene oxide nano-carriers for magnetic resonance imaging and drug delivery
Gadolinium (Gd)-based contrasts remain one of the most accepted contrast agents for magnetic resonance imaging, which is among the world most recognized noninvasive techniques employed in clinical diagnosis of patients. At ionic state, Gd is considered toxic but less toxic in chelate form. A variety...
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| Format: | Article |
| Language: | English |
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Chemistry Central
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/61931/1/Gadolinium-based%20layered%20double%20hydroxide%20and%20graphene%20oxide%20nano-carriers%20for%20magnetic%20resonance%20imaging%20and%20drug%20delivery.pdf |
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| author | Usman, Muhammad Sani Hussein, Mohd Zobir Fakurazi, Sharida Ahmad Saad, Fathinul Fikri |
| author_facet | Usman, Muhammad Sani Hussein, Mohd Zobir Fakurazi, Sharida Ahmad Saad, Fathinul Fikri |
| author_sort | Usman, Muhammad Sani |
| collection | UPM |
| description | Gadolinium (Gd)-based contrasts remain one of the most accepted contrast agents for magnetic resonance imaging, which is among the world most recognized noninvasive techniques employed in clinical diagnosis of patients. At ionic state, Gd is considered toxic but less toxic in chelate form. A variety of nano-carriers, including gadolinium oxide (Gd2O3) nanoparticles have been used by researchers to improve the T1 and T2 contrasts of MR images. Even more recently, a few researchers have tried to incorporate contrast agents simultaneously with therapeutic agents using single nano-carrier for theranostic applications. The benefit of this concept is to deliver the drugs, such as anticancer drugs and at the same time to observe what happens to the cancerous cells. The delivery of both agents occurs concurrently. In addition, the toxicity of the anticancer drugs as well as the contrast agents will be significantly reduced due to the presence of the nano-carriers. The use of graphene oxide (GO) and layered double hydroxides (LDH) as candidates for this purpose is the subject of current research, due to their low toxicity and biocompatibility, which have the capacity to be used in theranostic researches. We review here, some of the key features of LDH and GO for simultaneous drugs and diagnostic agents delivery systems for use in theranostics applications. |
| first_indexed | 2024-03-06T09:41:38Z |
| format | Article |
| id | upm.eprints-61931 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:41:38Z |
| publishDate | 2017 |
| publisher | Chemistry Central |
| record_format | dspace |
| spelling | upm.eprints-619312019-02-27T08:56:17Z http://psasir.upm.edu.my/id/eprint/61931/ Gadolinium-based layered double hydroxide and graphene oxide nano-carriers for magnetic resonance imaging and drug delivery Usman, Muhammad Sani Hussein, Mohd Zobir Fakurazi, Sharida Ahmad Saad, Fathinul Fikri Gadolinium (Gd)-based contrasts remain one of the most accepted contrast agents for magnetic resonance imaging, which is among the world most recognized noninvasive techniques employed in clinical diagnosis of patients. At ionic state, Gd is considered toxic but less toxic in chelate form. A variety of nano-carriers, including gadolinium oxide (Gd2O3) nanoparticles have been used by researchers to improve the T1 and T2 contrasts of MR images. Even more recently, a few researchers have tried to incorporate contrast agents simultaneously with therapeutic agents using single nano-carrier for theranostic applications. The benefit of this concept is to deliver the drugs, such as anticancer drugs and at the same time to observe what happens to the cancerous cells. The delivery of both agents occurs concurrently. In addition, the toxicity of the anticancer drugs as well as the contrast agents will be significantly reduced due to the presence of the nano-carriers. The use of graphene oxide (GO) and layered double hydroxides (LDH) as candidates for this purpose is the subject of current research, due to their low toxicity and biocompatibility, which have the capacity to be used in theranostic researches. We review here, some of the key features of LDH and GO for simultaneous drugs and diagnostic agents delivery systems for use in theranostics applications. Chemistry Central 2017-12 Article NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/61931/1/Gadolinium-based%20layered%20double%20hydroxide%20and%20graphene%20oxide%20nano-carriers%20for%20magnetic%20resonance%20imaging%20and%20drug%20delivery.pdf Usman, Muhammad Sani and Hussein, Mohd Zobir and Fakurazi, Sharida and Ahmad Saad, Fathinul Fikri (2017) Gadolinium-based layered double hydroxide and graphene oxide nano-carriers for magnetic resonance imaging and drug delivery. Chemistry Central Journal, 11. pp. 1-10. ISSN 1752-153X https://link.springer.com/article/10.1186/s13065-017-0275-3 10.1186/s13065-017-0275-3 |
| spellingShingle | Usman, Muhammad Sani Hussein, Mohd Zobir Fakurazi, Sharida Ahmad Saad, Fathinul Fikri Gadolinium-based layered double hydroxide and graphene oxide nano-carriers for magnetic resonance imaging and drug delivery |
| title | Gadolinium-based layered double hydroxide and graphene oxide nano-carriers for magnetic resonance imaging and drug delivery |
| title_full | Gadolinium-based layered double hydroxide and graphene oxide nano-carriers for magnetic resonance imaging and drug delivery |
| title_fullStr | Gadolinium-based layered double hydroxide and graphene oxide nano-carriers for magnetic resonance imaging and drug delivery |
| title_full_unstemmed | Gadolinium-based layered double hydroxide and graphene oxide nano-carriers for magnetic resonance imaging and drug delivery |
| title_short | Gadolinium-based layered double hydroxide and graphene oxide nano-carriers for magnetic resonance imaging and drug delivery |
| title_sort | gadolinium based layered double hydroxide and graphene oxide nano carriers for magnetic resonance imaging and drug delivery |
| url | http://psasir.upm.edu.my/id/eprint/61931/1/Gadolinium-based%20layered%20double%20hydroxide%20and%20graphene%20oxide%20nano-carriers%20for%20magnetic%20resonance%20imaging%20and%20drug%20delivery.pdf |
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