Ultrastructural pathology of nasal and tracheal mucosa of rabbits experimentally infected with Pasteurella multocida serotype D:1
Sixteen 8- to 9-week-old Pasteurella multocida-free New Zealand White rabbits were divided into two equal groups. The first group was inoculated intranasally with P multocida serotype D:1 strain and the second group that was inoculated with phosphate-buffered saline (PBS) only was used as a contro...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
Harcourt Publishers Limited
2001
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/6251/1/Ultrastructural%20pathology%20of%20nasal%20and%20tracheal%20mucosa%20of%20rabbits%20experimentally%20infected%20with%20Pasteurella%20multocida%20serotype%20D.pdf |
| _version_ | 1796967127532437504 |
|---|---|
| author | Muthaffar Hussain, Al-Haddawi Sabri, Jasni Israf Ali, Daud Ahmad Saad, Mohd Zamri Mutalib, Abdul Rahim Abdul Rahman, Sheikh Omar |
| author_facet | Muthaffar Hussain, Al-Haddawi Sabri, Jasni Israf Ali, Daud Ahmad Saad, Mohd Zamri Mutalib, Abdul Rahim Abdul Rahman, Sheikh Omar |
| author_sort | Muthaffar Hussain, Al-Haddawi |
| collection | UPM |
| description | Sixteen 8- to 9-week-old Pasteurella multocida-free New Zealand White rabbits were divided into two equal groups. The first group
was inoculated intranasally with P multocida serotype D:1 strain and the second group that was inoculated with phosphate-buffered
saline (PBS) only was used as a control group. Pasteurella multocida was isolated from the nasal cavity of all infected rabbits in group
1 and from tracheal swabs of seven rabbits in this group. Four rabbits in group 1 died with clinical signs of septicaemia, two rabbits
had mucopurulent nasal discharge and pneumonic lesions and the other two did not show any clinical signs or gross lesions. The
ultrastructural changes detected were deciliation or clumping of cilia of ciliated epithelium, cellular swelling, vacuolation and sloughing. The subepithelial capillaries showed congestion, intravascular fibrin deposition, platelets aggregation and endothelial injury. Pasteurella multocida was observed attached to the injured endothelial cells. Heterophils, mast cells, vacuolated monocytes and macrophages infiltrated the lamina propria and between the degenerated epithelial cells. ©2001 Harcourt Publishers Ltd |
| first_indexed | 2024-03-06T07:09:22Z |
| format | Article |
| id | upm.eprints-6251 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:09:22Z |
| publishDate | 2001 |
| publisher | Harcourt Publishers Limited |
| record_format | dspace |
| spelling | upm.eprints-62512015-10-26T03:51:47Z http://psasir.upm.edu.my/id/eprint/6251/ Ultrastructural pathology of nasal and tracheal mucosa of rabbits experimentally infected with Pasteurella multocida serotype D:1 Muthaffar Hussain, Al-Haddawi Sabri, Jasni Israf Ali, Daud Ahmad Saad, Mohd Zamri Mutalib, Abdul Rahim Abdul Rahman, Sheikh Omar Sixteen 8- to 9-week-old Pasteurella multocida-free New Zealand White rabbits were divided into two equal groups. The first group was inoculated intranasally with P multocida serotype D:1 strain and the second group that was inoculated with phosphate-buffered saline (PBS) only was used as a control group. Pasteurella multocida was isolated from the nasal cavity of all infected rabbits in group 1 and from tracheal swabs of seven rabbits in this group. Four rabbits in group 1 died with clinical signs of septicaemia, two rabbits had mucopurulent nasal discharge and pneumonic lesions and the other two did not show any clinical signs or gross lesions. The ultrastructural changes detected were deciliation or clumping of cilia of ciliated epithelium, cellular swelling, vacuolation and sloughing. The subepithelial capillaries showed congestion, intravascular fibrin deposition, platelets aggregation and endothelial injury. Pasteurella multocida was observed attached to the injured endothelial cells. Heterophils, mast cells, vacuolated monocytes and macrophages infiltrated the lamina propria and between the degenerated epithelial cells. ©2001 Harcourt Publishers Ltd Harcourt Publishers Limited 2001-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/6251/1/Ultrastructural%20pathology%20of%20nasal%20and%20tracheal%20mucosa%20of%20rabbits%20experimentally%20infected%20with%20Pasteurella%20multocida%20serotype%20D.pdf Muthaffar Hussain, Al-Haddawi and Sabri, Jasni and Israf Ali, Daud Ahmad and Saad, Mohd Zamri and Mutalib, Abdul Rahim and Abdul Rahman, Sheikh Omar (2001) Ultrastructural pathology of nasal and tracheal mucosa of rabbits experimentally infected with Pasteurella multocida serotype D:1. Research in Veterinary Science, 70 (3). pp. 191-197. ISSN 0034-5288 http://dx.doi.org/10.1053/rvsc.2001.0459 10.1053/rvsc.2001.0459 English |
| spellingShingle | Muthaffar Hussain, Al-Haddawi Sabri, Jasni Israf Ali, Daud Ahmad Saad, Mohd Zamri Mutalib, Abdul Rahim Abdul Rahman, Sheikh Omar Ultrastructural pathology of nasal and tracheal mucosa of rabbits experimentally infected with Pasteurella multocida serotype D:1 |
| title | Ultrastructural pathology of nasal and tracheal mucosa of
rabbits experimentally infected with Pasteurella multocida
serotype D:1 |
| title_full | Ultrastructural pathology of nasal and tracheal mucosa of
rabbits experimentally infected with Pasteurella multocida
serotype D:1 |
| title_fullStr | Ultrastructural pathology of nasal and tracheal mucosa of
rabbits experimentally infected with Pasteurella multocida
serotype D:1 |
| title_full_unstemmed | Ultrastructural pathology of nasal and tracheal mucosa of
rabbits experimentally infected with Pasteurella multocida
serotype D:1 |
| title_short | Ultrastructural pathology of nasal and tracheal mucosa of
rabbits experimentally infected with Pasteurella multocida
serotype D:1 |
| title_sort | ultrastructural pathology of nasal and tracheal mucosa of rabbits experimentally infected with pasteurella multocida serotype d 1 |
| url | http://psasir.upm.edu.my/id/eprint/6251/1/Ultrastructural%20pathology%20of%20nasal%20and%20tracheal%20mucosa%20of%20rabbits%20experimentally%20infected%20with%20Pasteurella%20multocida%20serotype%20D.pdf |
| work_keys_str_mv | AT muthaffarhussainalhaddawi ultrastructuralpathologyofnasalandtrachealmucosaofrabbitsexperimentallyinfectedwithpasteurellamultocidaserotyped1 AT sabrijasni ultrastructuralpathologyofnasalandtrachealmucosaofrabbitsexperimentallyinfectedwithpasteurellamultocidaserotyped1 AT israfalidaudahmad ultrastructuralpathologyofnasalandtrachealmucosaofrabbitsexperimentallyinfectedwithpasteurellamultocidaserotyped1 AT saadmohdzamri ultrastructuralpathologyofnasalandtrachealmucosaofrabbitsexperimentallyinfectedwithpasteurellamultocidaserotyped1 AT mutalibabdulrahim ultrastructuralpathologyofnasalandtrachealmucosaofrabbitsexperimentallyinfectedwithpasteurellamultocidaserotyped1 AT abdulrahmansheikhomar ultrastructuralpathologyofnasalandtrachealmucosaofrabbitsexperimentallyinfectedwithpasteurellamultocidaserotyped1 |