Prepration and characterization of Cu-. Fe-, Ag-, Zn- and Ni-doped gelatin nanofibers for possible appliactions in antibacterial nanomedicine
A facile and efficient approach to prepare metal nanoparticles doped electrospun gelatin from metal salts precursors was successfully developed. The incorporation of metal ions with antimicrobial activity into electrospun gelatin (Ge-espun) is an attractive approach to control the inflammatory react...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor's University
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/62834/1/Prepration%20and%20characterization%20of%20Cu.pdf |
| _version_ | 1825932522378231808 |
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| author | Nuge, Tamrin Tshai, Kim Yeow Lim, Siew Shee Nordin, Norshariza Hoque, Md. Enamul |
| author_facet | Nuge, Tamrin Tshai, Kim Yeow Lim, Siew Shee Nordin, Norshariza Hoque, Md. Enamul |
| author_sort | Nuge, Tamrin |
| collection | UPM |
| description | A facile and efficient approach to prepare metal nanoparticles doped electrospun gelatin from metal salts precursors was successfully developed. The incorporation of metal ions with antimicrobial activity into electrospun gelatin (Ge-espun) is an attractive approach to control the inflammatory reaction and prevent infection in wound. In this study, metal salts precursors AgNO 3 , Fe(NO 3) 3 .9H 2 O, Cu(NO 3) 2 .3H 2 O, Zn(NO 3) 2 .6H 2 O and Ni(NO 3) 2 .6H 2 O were reduced to metal nanoparticles with acetic acid as solvent and reducing agent. The agglomeration of nanoparticles was inhibited by the gelatin polymer matrix. Electrospinning of both neat Ge-espun and metal-nanoparticles/Ge-espun resulted in the formation of smooth fibres with average diameters of ~280nm and ~40nm-150nm, respectively. The efficacy of metal nanoparticles/Ge-espun against bacteria commonly found on wounds was tested with different metal loading by measuring the inhibition of colony forming units. The results indicated a broad spectrum of antibacterial activity showed by Ag/Ge-espun, followed by Fe/Ge-espun and Zn/Ge-espun. An interesting finding on the efficacy of Cu/Ge-espun and Fe/Ge-espun against the Gram's positive bacteria is worth exploring to further investigate the potential application of metal-based antibiotics against the antibiotic-resistant bacterial strains. |
| first_indexed | 2024-03-06T09:43:19Z |
| format | Article |
| id | upm.eprints-62834 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:43:19Z |
| publishDate | 2017 |
| publisher | Taylor's University |
| record_format | dspace |
| spelling | upm.eprints-628342022-11-10T07:06:10Z http://psasir.upm.edu.my/id/eprint/62834/ Prepration and characterization of Cu-. Fe-, Ag-, Zn- and Ni-doped gelatin nanofibers for possible appliactions in antibacterial nanomedicine Nuge, Tamrin Tshai, Kim Yeow Lim, Siew Shee Nordin, Norshariza Hoque, Md. Enamul A facile and efficient approach to prepare metal nanoparticles doped electrospun gelatin from metal salts precursors was successfully developed. The incorporation of metal ions with antimicrobial activity into electrospun gelatin (Ge-espun) is an attractive approach to control the inflammatory reaction and prevent infection in wound. In this study, metal salts precursors AgNO 3 , Fe(NO 3) 3 .9H 2 O, Cu(NO 3) 2 .3H 2 O, Zn(NO 3) 2 .6H 2 O and Ni(NO 3) 2 .6H 2 O were reduced to metal nanoparticles with acetic acid as solvent and reducing agent. The agglomeration of nanoparticles was inhibited by the gelatin polymer matrix. Electrospinning of both neat Ge-espun and metal-nanoparticles/Ge-espun resulted in the formation of smooth fibres with average diameters of ~280nm and ~40nm-150nm, respectively. The efficacy of metal nanoparticles/Ge-espun against bacteria commonly found on wounds was tested with different metal loading by measuring the inhibition of colony forming units. The results indicated a broad spectrum of antibacterial activity showed by Ag/Ge-espun, followed by Fe/Ge-espun and Zn/Ge-espun. An interesting finding on the efficacy of Cu/Ge-espun and Fe/Ge-espun against the Gram's positive bacteria is worth exploring to further investigate the potential application of metal-based antibiotics against the antibiotic-resistant bacterial strains. Taylor's University 2017-03 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/62834/1/Prepration%20and%20characterization%20of%20Cu.pdf Nuge, Tamrin and Tshai, Kim Yeow and Lim, Siew Shee and Nordin, Norshariza and Hoque, Md. Enamul (2017) Prepration and characterization of Cu-. Fe-, Ag-, Zn- and Ni-doped gelatin nanofibers for possible appliactions in antibacterial nanomedicine. Journal of Engineering Science and Technology, spec. 1. 68 - 81. ISSN 1823-4690 https://jestec.taylors.edu.my/Special%20Issue%20eureca%202015_2/eureca5_paper%205.pdf |
| spellingShingle | Nuge, Tamrin Tshai, Kim Yeow Lim, Siew Shee Nordin, Norshariza Hoque, Md. Enamul Prepration and characterization of Cu-. Fe-, Ag-, Zn- and Ni-doped gelatin nanofibers for possible appliactions in antibacterial nanomedicine |
| title | Prepration and characterization of Cu-. Fe-, Ag-, Zn- and Ni-doped gelatin nanofibers for possible appliactions in antibacterial nanomedicine |
| title_full | Prepration and characterization of Cu-. Fe-, Ag-, Zn- and Ni-doped gelatin nanofibers for possible appliactions in antibacterial nanomedicine |
| title_fullStr | Prepration and characterization of Cu-. Fe-, Ag-, Zn- and Ni-doped gelatin nanofibers for possible appliactions in antibacterial nanomedicine |
| title_full_unstemmed | Prepration and characterization of Cu-. Fe-, Ag-, Zn- and Ni-doped gelatin nanofibers for possible appliactions in antibacterial nanomedicine |
| title_short | Prepration and characterization of Cu-. Fe-, Ag-, Zn- and Ni-doped gelatin nanofibers for possible appliactions in antibacterial nanomedicine |
| title_sort | prepration and characterization of cu fe ag zn and ni doped gelatin nanofibers for possible appliactions in antibacterial nanomedicine |
| url | http://psasir.upm.edu.my/id/eprint/62834/1/Prepration%20and%20characterization%20of%20Cu.pdf |
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