Glucosinolates and isothiocyanates: cancer preventive effects
The anticarcinogenic bioactivity of various isothiocyanates (ITCs) has been demonstrated in various animal models such as rats, mice, and hamsters, and in different target tissues such as lung, esophagus, and forestomach. A major chemopreventive mechanism of ITCs involves suppression of reactive met...
| Main Authors: | , , |
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| Format: | Book Section |
| Language: | English |
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John Wiley & Sons
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/63117/1/Glucosinolates%20and%20isothiocyanates.pdf |
| _version_ | 1825932554088218624 |
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| author | Abdull Razis, Ahmad Faizal Arumugam, Asvinidevi Konsue, Nattaya |
| author_facet | Abdull Razis, Ahmad Faizal Arumugam, Asvinidevi Konsue, Nattaya |
| author_sort | Abdull Razis, Ahmad Faizal |
| collection | UPM |
| description | The anticarcinogenic bioactivity of various isothiocyanates (ITCs) has been demonstrated in various animal models such as rats, mice, and hamsters, and in different target tissues such as lung, esophagus, and forestomach. A major chemopreventive mechanism of ITCs involves suppression of reactive metabolite generation and, therefore, a decrease in DNA adducts formation. Many in vitro studies have reported the effects of ITCs on cell cycle modulation and proapoptotic effects through a number of targets, at different points of the pathways. A comparative study in human subjects showed that the hydrolysis of glucosinolates and the absorption of ITCs are greater following ingestion of raw brassica with active plant myrosinase than after consumption of the cooked plant with denatured myrosinase. Apoptosis is considered a vital component of the cellular mechanisms responsible for the maintenance of homeostasis in multicellular organisms. Understanding the pathways of associated proteins provides an insight into the induction of apoptosis by anticancer agents. |
| first_indexed | 2024-03-06T09:43:49Z |
| format | Book Section |
| id | upm.eprints-63117 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:43:49Z |
| publishDate | 2017 |
| publisher | John Wiley & Sons |
| record_format | dspace |
| spelling | upm.eprints-631172019-11-13T06:22:53Z http://psasir.upm.edu.my/id/eprint/63117/ Glucosinolates and isothiocyanates: cancer preventive effects Abdull Razis, Ahmad Faizal Arumugam, Asvinidevi Konsue, Nattaya The anticarcinogenic bioactivity of various isothiocyanates (ITCs) has been demonstrated in various animal models such as rats, mice, and hamsters, and in different target tissues such as lung, esophagus, and forestomach. A major chemopreventive mechanism of ITCs involves suppression of reactive metabolite generation and, therefore, a decrease in DNA adducts formation. Many in vitro studies have reported the effects of ITCs on cell cycle modulation and proapoptotic effects through a number of targets, at different points of the pathways. A comparative study in human subjects showed that the hydrolysis of glucosinolates and the absorption of ITCs are greater following ingestion of raw brassica with active plant myrosinase than after consumption of the cooked plant with denatured myrosinase. Apoptosis is considered a vital component of the cellular mechanisms responsible for the maintenance of homeostasis in multicellular organisms. Understanding the pathways of associated proteins provides an insight into the induction of apoptosis by anticancer agents. John Wiley & Sons 2017-10 Book Section PeerReviewed text en http://psasir.upm.edu.my/id/eprint/63117/1/Glucosinolates%20and%20isothiocyanates.pdf Abdull Razis, Ahmad Faizal and Arumugam, Asvinidevi and Konsue, Nattaya (2017) Glucosinolates and isothiocyanates: cancer preventive effects. In: Fruit and Vegetable Phytochemicals: Chemistry and Human Health. John Wiley & Sons, 199 - 210. ISBN 9781119157946; EISBN: 9781119158042 https://onlinelibrary.wiley.com/doi/abs/10.1002/9781119158042.ch11 10.1002/9781119158042.ch11 |
| spellingShingle | Abdull Razis, Ahmad Faizal Arumugam, Asvinidevi Konsue, Nattaya Glucosinolates and isothiocyanates: cancer preventive effects |
| title | Glucosinolates and isothiocyanates: cancer preventive effects |
| title_full | Glucosinolates and isothiocyanates: cancer preventive effects |
| title_fullStr | Glucosinolates and isothiocyanates: cancer preventive effects |
| title_full_unstemmed | Glucosinolates and isothiocyanates: cancer preventive effects |
| title_short | Glucosinolates and isothiocyanates: cancer preventive effects |
| title_sort | glucosinolates and isothiocyanates cancer preventive effects |
| url | http://psasir.upm.edu.my/id/eprint/63117/1/Glucosinolates%20and%20isothiocyanates.pdf |
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