Synthesis of N-Alkylated and N-Acylated derivatives of girinimbine
Girinimbine, a carbazole alkaloid has drawn an attention due to its wide range of pharmacological effects such as antiplatelet, antibacterial and anticancer activities. Five new derivatives of girinimbine were successfully semi-synthesized via modification on N-terminal of naturally isolated girinim...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Asian Publication Corporation
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/63365/1/Synthesis%20of%20N-Alkylated%20and%20N-Acylated%20derivatives%20of%20girinimbine.pdf |
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| author | Nor, Siti Mariam Mohd Osman, Fatin Nurul Atiqah Ahmad, Kartini Nafiah, Mohd Azlan |
| author_facet | Nor, Siti Mariam Mohd Osman, Fatin Nurul Atiqah Ahmad, Kartini Nafiah, Mohd Azlan |
| author_sort | Nor, Siti Mariam Mohd |
| collection | UPM |
| description | Girinimbine, a carbazole alkaloid has drawn an attention due to its wide range of pharmacological effects such as antiplatelet, antibacterial and anticancer activities. Five new derivatives of girinimbine were successfully semi-synthesized via modification on N-terminal of naturally isolated girinimbine. N-Benzylgirinimbine, N-butylgirinimbine and N-isopentylgirinimbine were obtained from alkylation reaction, whereas, N-butyrylgirinimbine and N-methylbutyrylgirinimbine were obtained from acylation reaction. The structures of synthesized girinimbine derivatives were confirmed by spectroscopic techniques. |
| first_indexed | 2024-03-06T09:44:21Z |
| format | Article |
| id | upm.eprints-63365 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:44:21Z |
| publishDate | 2017 |
| publisher | Asian Publication Corporation |
| record_format | dspace |
| spelling | upm.eprints-633652018-10-16T00:26:55Z http://psasir.upm.edu.my/id/eprint/63365/ Synthesis of N-Alkylated and N-Acylated derivatives of girinimbine Nor, Siti Mariam Mohd Osman, Fatin Nurul Atiqah Ahmad, Kartini Nafiah, Mohd Azlan Girinimbine, a carbazole alkaloid has drawn an attention due to its wide range of pharmacological effects such as antiplatelet, antibacterial and anticancer activities. Five new derivatives of girinimbine were successfully semi-synthesized via modification on N-terminal of naturally isolated girinimbine. N-Benzylgirinimbine, N-butylgirinimbine and N-isopentylgirinimbine were obtained from alkylation reaction, whereas, N-butyrylgirinimbine and N-methylbutyrylgirinimbine were obtained from acylation reaction. The structures of synthesized girinimbine derivatives were confirmed by spectroscopic techniques. Asian Publication Corporation 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/63365/1/Synthesis%20of%20N-Alkylated%20and%20N-Acylated%20derivatives%20of%20girinimbine.pdf Nor, Siti Mariam Mohd and Osman, Fatin Nurul Atiqah and Ahmad, Kartini and Nafiah, Mohd Azlan (2017) Synthesis of N-Alkylated and N-Acylated derivatives of girinimbine. Asian Journal of Chemistry, 29 (4). 801 - 804. ISSN 0970-7077; ESSN: 0975-427X http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=29_4_19 10.14233/ajchem.2017.20316 |
| spellingShingle | Nor, Siti Mariam Mohd Osman, Fatin Nurul Atiqah Ahmad, Kartini Nafiah, Mohd Azlan Synthesis of N-Alkylated and N-Acylated derivatives of girinimbine |
| title | Synthesis of N-Alkylated and N-Acylated derivatives of girinimbine |
| title_full | Synthesis of N-Alkylated and N-Acylated derivatives of girinimbine |
| title_fullStr | Synthesis of N-Alkylated and N-Acylated derivatives of girinimbine |
| title_full_unstemmed | Synthesis of N-Alkylated and N-Acylated derivatives of girinimbine |
| title_short | Synthesis of N-Alkylated and N-Acylated derivatives of girinimbine |
| title_sort | synthesis of n alkylated and n acylated derivatives of girinimbine |
| url | http://psasir.upm.edu.my/id/eprint/63365/1/Synthesis%20of%20N-Alkylated%20and%20N-Acylated%20derivatives%20of%20girinimbine.pdf |
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