The effect of viscosity, friction, and sonication on the morphology and metabolite production from Aspergillus terreus ATCC 20542
This study investigates the effects of viscosity, friction, and sonication on the morphology and the production of lovastatin, (+)-geodin, and sulochrin by Aspergillus terreus ATCC 20542. Sodium alginate and gelatine were used to protect the fungal pellet from mechanical force by increasing the medi...
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| Format: | Article |
| Language: | English |
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Springer
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/63437/1/The%20effect%20of%20viscosity%2C%20friction%2C%20and%20sonication%20on%20the%20morphology%20and%20metabolite%20production%20from%20Aspergillus%20terreus%20ATCC%2020542.pdf |
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| author | Rahim, Muhamad Hafiz Abd Hasan, Hanan Harith, Hanis H. Abbas, Ali |
| author_facet | Rahim, Muhamad Hafiz Abd Hasan, Hanan Harith, Hanis H. Abbas, Ali |
| author_sort | Rahim, Muhamad Hafiz Abd |
| collection | UPM |
| description | This study investigates the effects of viscosity, friction, and sonication on the morphology and the production of lovastatin, (+)-geodin, and sulochrin by Aspergillus terreus ATCC 20542. Sodium alginate and gelatine were used to protect the fungal pellet from mechanical force by increasing the media viscosity. Sodium alginate stimulated the production of lovastatin by up to 329.0% and sulochrin by 128.7%, with inhibitory effect on (+)-geodin production at all concentrations used. However, the use of gelatine to increase viscosity significantly suppressed lovastatin, (+)-geodin, and sulochrin’s production (maximum reduction at day 9 of 42.7, 60.8, and 68.3%, respectively), which indicated that the types of chemical play a major role in metabolite production. Higher viscosity increased both pellet biomass and size in all conditions. Friction significantly increased (+)-geodin’s titre by 1527.5%, lovastatin by 511.1%, and sulochrin by 784.4% while reducing pellet biomass and size. Conversely, sonication produced disperse filamentous morphology with significantly lower metabolites. Sodium alginate-induced lovastatin and sulochrin production suggest that these metabolites are not affected by viscosity; rather, their production is affected by the specific action of certain chemicals. In contrast, low viscosity adversely affected (+)-geodin’s production, while pellet disintegration can cause a significant production of (+)-geodin. |
| first_indexed | 2024-03-06T09:44:32Z |
| format | Article |
| id | upm.eprints-63437 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:44:32Z |
| publishDate | 2017 |
| publisher | Springer |
| record_format | dspace |
| spelling | upm.eprints-634372018-10-16T09:30:47Z http://psasir.upm.edu.my/id/eprint/63437/ The effect of viscosity, friction, and sonication on the morphology and metabolite production from Aspergillus terreus ATCC 20542 Rahim, Muhamad Hafiz Abd Hasan, Hanan Harith, Hanis H. Abbas, Ali This study investigates the effects of viscosity, friction, and sonication on the morphology and the production of lovastatin, (+)-geodin, and sulochrin by Aspergillus terreus ATCC 20542. Sodium alginate and gelatine were used to protect the fungal pellet from mechanical force by increasing the media viscosity. Sodium alginate stimulated the production of lovastatin by up to 329.0% and sulochrin by 128.7%, with inhibitory effect on (+)-geodin production at all concentrations used. However, the use of gelatine to increase viscosity significantly suppressed lovastatin, (+)-geodin, and sulochrin’s production (maximum reduction at day 9 of 42.7, 60.8, and 68.3%, respectively), which indicated that the types of chemical play a major role in metabolite production. Higher viscosity increased both pellet biomass and size in all conditions. Friction significantly increased (+)-geodin’s titre by 1527.5%, lovastatin by 511.1%, and sulochrin by 784.4% while reducing pellet biomass and size. Conversely, sonication produced disperse filamentous morphology with significantly lower metabolites. Sodium alginate-induced lovastatin and sulochrin production suggest that these metabolites are not affected by viscosity; rather, their production is affected by the specific action of certain chemicals. In contrast, low viscosity adversely affected (+)-geodin’s production, while pellet disintegration can cause a significant production of (+)-geodin. Springer 2017-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/63437/1/The%20effect%20of%20viscosity%2C%20friction%2C%20and%20sonication%20on%20the%20morphology%20and%20metabolite%20production%20from%20Aspergillus%20terreus%20ATCC%2020542.pdf Rahim, Muhamad Hafiz Abd and Hasan, Hanan and Harith, Hanis H. and Abbas, Ali (2017) The effect of viscosity, friction, and sonication on the morphology and metabolite production from Aspergillus terreus ATCC 20542. Bioprocess and Biosystems Engineering, 40 (12). 1753 - 1761. ISSN 1615-7591; ESSN: 1615-7605 https://link.springer.com/article/10.1007/s00449-017-1830-y 10.1007/s00449-017-1830-y |
| spellingShingle | Rahim, Muhamad Hafiz Abd Hasan, Hanan Harith, Hanis H. Abbas, Ali The effect of viscosity, friction, and sonication on the morphology and metabolite production from Aspergillus terreus ATCC 20542 |
| title | The effect of viscosity, friction, and sonication on the morphology and metabolite production from Aspergillus terreus ATCC 20542 |
| title_full | The effect of viscosity, friction, and sonication on the morphology and metabolite production from Aspergillus terreus ATCC 20542 |
| title_fullStr | The effect of viscosity, friction, and sonication on the morphology and metabolite production from Aspergillus terreus ATCC 20542 |
| title_full_unstemmed | The effect of viscosity, friction, and sonication on the morphology and metabolite production from Aspergillus terreus ATCC 20542 |
| title_short | The effect of viscosity, friction, and sonication on the morphology and metabolite production from Aspergillus terreus ATCC 20542 |
| title_sort | effect of viscosity friction and sonication on the morphology and metabolite production from aspergillus terreus atcc 20542 |
| url | http://psasir.upm.edu.my/id/eprint/63437/1/The%20effect%20of%20viscosity%2C%20friction%2C%20and%20sonication%20on%20the%20morphology%20and%20metabolite%20production%20from%20Aspergillus%20terreus%20ATCC%2020542.pdf |
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