The in vivo anti-tumor effect of curcumin derivative (2 E,6 E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) on 4T1 breast cancer cells
Curcumin is one of the promising natural products extracted from the rhizomes of curcuma longa and has been extensively investigated by researchers to explore its potential as a chemopreventive and therapeutic agent against several chronic diseases. To further enhance the cytotoxic potential of curc...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2017
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/63554/1/The%20in%20vivo%20anti-tumor%20effect%20of%20curcumin%20derivative%20%282E%2C6E%29-2%2C6-bis%284-hydroxy-3-methoxybenzylidene%29cyclohexanone%20%28BHMC%29%20on%204T1%20breast%20cancer%20cells.pdf |
| _version_ | 1825932621163528192 |
|---|---|
| author | Razak, Nursyamirah Abd Akhtar, M. Nadeem Abu, Nadiah Wan, Yong Ho Sheau, Wei Tan Zareen, Seema Taj-ud-din, Saiful Nizam Long, Kamariah Alitheen, Noorjahan Banu Swee, Keong Yeap |
| author_facet | Razak, Nursyamirah Abd Akhtar, M. Nadeem Abu, Nadiah Wan, Yong Ho Sheau, Wei Tan Zareen, Seema Taj-ud-din, Saiful Nizam Long, Kamariah Alitheen, Noorjahan Banu Swee, Keong Yeap |
| author_sort | Razak, Nursyamirah Abd |
| collection | UPM |
| description | Curcumin is one of the promising natural products extracted from the rhizomes of curcuma longa and has been extensively investigated by researchers to explore its potential as a chemopreventive and therapeutic agent against several chronic diseases. To further enhance the cytotoxic potential of curcumin, its derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) has been synthesized and investigated, and its antitumor effect on tested on 4T1 challenged mice. BHMC was recorded with in vitro cytotoxicity on murine 4T1 breast cancer cells with IC50 value 13.66 μM, which was 2 times lower than curcumin after 72 hours of treatment. An in vivo study indicated that BHMC possessed antitumor effect on the 4T1 cells of the challenged mice by induction of apoptosis, antiproliferation, anti-inflammation and antimetastasis. This effect is better compared to curcumin treatment at the same evaluated concentration. Thus, BHMC is a potential antitumor agent against breast cancer. |
| first_indexed | 2024-03-06T09:44:50Z |
| format | Article |
| id | upm.eprints-63554 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:44:50Z |
| publishDate | 2017 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | upm.eprints-635542018-11-05T03:29:30Z http://psasir.upm.edu.my/id/eprint/63554/ The in vivo anti-tumor effect of curcumin derivative (2 E,6 E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) on 4T1 breast cancer cells Razak, Nursyamirah Abd Akhtar, M. Nadeem Abu, Nadiah Wan, Yong Ho Sheau, Wei Tan Zareen, Seema Taj-ud-din, Saiful Nizam Long, Kamariah Alitheen, Noorjahan Banu Swee, Keong Yeap Curcumin is one of the promising natural products extracted from the rhizomes of curcuma longa and has been extensively investigated by researchers to explore its potential as a chemopreventive and therapeutic agent against several chronic diseases. To further enhance the cytotoxic potential of curcumin, its derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) has been synthesized and investigated, and its antitumor effect on tested on 4T1 challenged mice. BHMC was recorded with in vitro cytotoxicity on murine 4T1 breast cancer cells with IC50 value 13.66 μM, which was 2 times lower than curcumin after 72 hours of treatment. An in vivo study indicated that BHMC possessed antitumor effect on the 4T1 cells of the challenged mice by induction of apoptosis, antiproliferation, anti-inflammation and antimetastasis. This effect is better compared to curcumin treatment at the same evaluated concentration. Thus, BHMC is a potential antitumor agent against breast cancer. Royal Society of Chemistry 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/63554/1/The%20in%20vivo%20anti-tumor%20effect%20of%20curcumin%20derivative%20%282E%2C6E%29-2%2C6-bis%284-hydroxy-3-methoxybenzylidene%29cyclohexanone%20%28BHMC%29%20on%204T1%20breast%20cancer%20cells.pdf Razak, Nursyamirah Abd and Akhtar, M. Nadeem and Abu, Nadiah and Wan, Yong Ho and Sheau, Wei Tan and Zareen, Seema and Taj-ud-din, Saiful Nizam and Long, Kamariah and Alitheen, Noorjahan Banu and Swee, Keong Yeap (2017) The in vivo anti-tumor effect of curcumin derivative (2 E,6 E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) on 4T1 breast cancer cells. RSC Advances, 7 (57). 36185 - 36192. ISSN 2046-2069 10.1039/c7ra06580a |
| spellingShingle | Razak, Nursyamirah Abd Akhtar, M. Nadeem Abu, Nadiah Wan, Yong Ho Sheau, Wei Tan Zareen, Seema Taj-ud-din, Saiful Nizam Long, Kamariah Alitheen, Noorjahan Banu Swee, Keong Yeap The in vivo anti-tumor effect of curcumin derivative (2 E,6 E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) on 4T1 breast cancer cells |
| title | The in vivo anti-tumor effect of curcumin derivative (2 E,6 E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) on 4T1 breast cancer cells |
| title_full | The in vivo anti-tumor effect of curcumin derivative (2 E,6 E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) on 4T1 breast cancer cells |
| title_fullStr | The in vivo anti-tumor effect of curcumin derivative (2 E,6 E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) on 4T1 breast cancer cells |
| title_full_unstemmed | The in vivo anti-tumor effect of curcumin derivative (2 E,6 E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) on 4T1 breast cancer cells |
| title_short | The in vivo anti-tumor effect of curcumin derivative (2 E,6 E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) on 4T1 breast cancer cells |
| title_sort | in vivo anti tumor effect of curcumin derivative 2 e 6 e 2 6 bis 4 hydroxy 3 methoxybenzylidene cyclohexanone bhmc on 4t1 breast cancer cells |
| url | http://psasir.upm.edu.my/id/eprint/63554/1/The%20in%20vivo%20anti-tumor%20effect%20of%20curcumin%20derivative%20%282E%2C6E%29-2%2C6-bis%284-hydroxy-3-methoxybenzylidene%29cyclohexanone%20%28BHMC%29%20on%204T1%20breast%20cancer%20cells.pdf |
| work_keys_str_mv | AT razaknursyamirahabd theinvivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT akhtarmnadeem theinvivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT abunadiah theinvivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT wanyongho theinvivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT sheauweitan theinvivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT zareenseema theinvivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT tajuddinsaifulnizam theinvivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT longkamariah theinvivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT alitheennoorjahanbanu theinvivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT sweekeongyeap theinvivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT razaknursyamirahabd invivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT akhtarmnadeem invivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT abunadiah invivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT wanyongho invivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT sheauweitan invivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT zareenseema invivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT tajuddinsaifulnizam invivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT longkamariah invivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT alitheennoorjahanbanu invivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells AT sweekeongyeap invivoantitumoreffectofcurcuminderivative2e6e26bis4hydroxy3methoxybenzylidenecyclohexanonebhmcon4t1breastcancercells |