Thymoquinone-rich fraction nanoemulsion (TQRFNE) decreases Aβ40 and Aβ42 levels by modulating APP processing, up-regulating IDE and LRP1, and down-regulating BACE1 and RAGE in response to high fat/cholesterol diet-induced rats

Thymoquinone-rich fraction nanoemulsion (TQRFNE) decreases Aβ40 and Aβ42 levels by modulating APP processing, up-regulating IDE and LRP1, and down-regulating BACE1 and RAGE in response to high fat/cholesterol diet-induced rats

Though the causes of Alzheimer’s disease (AD) are yet to be understood, much evidence has suggested that excessive amyloid-β (Aβ) accumulation due to abnormal amyloid-β precursor protein (APP) processing and Aβ metabolism are crucial processes towards AD pathogenesis. Hence, approaches aiming at APP...

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Bibliographic Details
Main Authors: Ismail, Norsharina, Ismail, Maznah, Azmi, Nur Hanisah, Bakar, Muhammad Firdaus Abu, Yida, Zhang, Abdullah, Maizaton Atmadini, Basri, Hamidon
Format: Article
Language:English
Published: Elsevier 2017
Online Access:http://psasir.upm.edu.my/id/eprint/63573/1/Thymoquinone-rich%20fraction%20nanoemulsion%20%28TQRFNE%29%20decreases%20A%CE%B240%20and%20A%CE%B242%20levels.pdf

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