Bioactive constituents from lengkuas ranting (Alpinia conchigera)
Zingiberaceae is one of the most important herbaceous species found in tropical forests which comprises about 52 genera with 1500 species in the world. Isolation work on crude extracts of Alpinia conchigera yielded p-hydroxycinnamaldehyde and β-sitosterol-3-O-β-D-glucopyranoside which are new to the...
| Main Authors: | , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
Sarawak Biodiversity Centre
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/64272/1/PROCEEDING_100719-10.pdf |
| _version_ | 1796977865230647296 |
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| author | Md. Sukari, Mohd Aspollah Tang, Sook Wah Rahmani, Mawardi Lajis, Md. Nordin Ali, Abdul Manaf |
| author_facet | Md. Sukari, Mohd Aspollah Tang, Sook Wah Rahmani, Mawardi Lajis, Md. Nordin Ali, Abdul Manaf |
| author_sort | Md. Sukari, Mohd Aspollah |
| collection | UPM |
| description | Zingiberaceae is one of the most important herbaceous species found in tropical forests which comprises about 52 genera with 1500 species in the world. Isolation work on crude extracts of Alpinia conchigera yielded p-hydroxycinnamaldehyde and β-sitosterol-3-O-β-D-glucopyranoside which are new to the species besides β-sitosterol. Extracts and p-hydroxycinnamaldehyde were subjected to cytotoxic testing against different cancer cell lines (HL-60, MCF-7, HeLa and HT-29) as well as antimicrobial testing. Crude hexane, chloroform and ethyl acetate extracts were strongly active against Salmonella choleraesuis in antimicrobial assay. In antifungal screening test, hexane extract showed slight inhibition on Aspergillus ochraceaus and Saccharomyces cerevisiae while ethyl acetate extract was active towards S. cerevisiae. All crude extracts except methanol extract exhibited very strong activity in cytotoxic screening test against HL-60 cell line (human promyelocytic leukemia) with IC50 values < 5 μg/mL. p- Hydroxycinnamaldehyde is cytotoxic against all cancerous cell lines tested and strongly active in antimicrobial testing. |
| first_indexed | 2024-03-06T09:46:18Z |
| format | Conference or Workshop Item |
| id | upm.eprints-64272 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:46:18Z |
| publishDate | 2008 |
| publisher | Sarawak Biodiversity Centre |
| record_format | dspace |
| spelling | upm.eprints-642722018-07-04T02:31:44Z http://psasir.upm.edu.my/id/eprint/64272/ Bioactive constituents from lengkuas ranting (Alpinia conchigera) Md. Sukari, Mohd Aspollah Tang, Sook Wah Rahmani, Mawardi Lajis, Md. Nordin Ali, Abdul Manaf Zingiberaceae is one of the most important herbaceous species found in tropical forests which comprises about 52 genera with 1500 species in the world. Isolation work on crude extracts of Alpinia conchigera yielded p-hydroxycinnamaldehyde and β-sitosterol-3-O-β-D-glucopyranoside which are new to the species besides β-sitosterol. Extracts and p-hydroxycinnamaldehyde were subjected to cytotoxic testing against different cancer cell lines (HL-60, MCF-7, HeLa and HT-29) as well as antimicrobial testing. Crude hexane, chloroform and ethyl acetate extracts were strongly active against Salmonella choleraesuis in antimicrobial assay. In antifungal screening test, hexane extract showed slight inhibition on Aspergillus ochraceaus and Saccharomyces cerevisiae while ethyl acetate extract was active towards S. cerevisiae. All crude extracts except methanol extract exhibited very strong activity in cytotoxic screening test against HL-60 cell line (human promyelocytic leukemia) with IC50 values < 5 μg/mL. p- Hydroxycinnamaldehyde is cytotoxic against all cancerous cell lines tested and strongly active in antimicrobial testing. Sarawak Biodiversity Centre 2008 Conference or Workshop Item PeerReviewed text en http://psasir.upm.edu.my/id/eprint/64272/1/PROCEEDING_100719-10.pdf Md. Sukari, Mohd Aspollah and Tang, Sook Wah and Rahmani, Mawardi and Lajis, Md. Nordin and Ali, Abdul Manaf (2008) Bioactive constituents from lengkuas ranting (Alpinia conchigera). In: Biodiversity and Biotechnology Symposium 2008, 19-21 Nov. 2008, Kuching, Sarawak, Malaysia. (pp. 285-287). |
| spellingShingle | Md. Sukari, Mohd Aspollah Tang, Sook Wah Rahmani, Mawardi Lajis, Md. Nordin Ali, Abdul Manaf Bioactive constituents from lengkuas ranting (Alpinia conchigera) |
| title | Bioactive constituents from lengkuas ranting (Alpinia conchigera) |
| title_full | Bioactive constituents from lengkuas ranting (Alpinia conchigera) |
| title_fullStr | Bioactive constituents from lengkuas ranting (Alpinia conchigera) |
| title_full_unstemmed | Bioactive constituents from lengkuas ranting (Alpinia conchigera) |
| title_short | Bioactive constituents from lengkuas ranting (Alpinia conchigera) |
| title_sort | bioactive constituents from lengkuas ranting alpinia conchigera |
| url | http://psasir.upm.edu.my/id/eprint/64272/1/PROCEEDING_100719-10.pdf |
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