The effect of non-steroidal anti-inflammatory drugs on carrageenan-induced paw oedema in rats
Ketoprofen, meloxicam, celecoxib and rofecoxib were used in the present study to investigate the effects of NSAIDs on carrageenan-induced paw oedema in rats. Acute inflammation was induced by subplantar injection of carrageenan (0.1 ml, 1 % w/v) into the rat hind paw. Celecoxib (10 mg/kg) caused sig...
| Main Authors: | , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
Universiti Putra Malaysia Press
2004
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| Online Access: | http://psasir.upm.edu.my/id/eprint/65116/1/71-32.pdf |
| Summary: | Ketoprofen, meloxicam, celecoxib and rofecoxib were used in the present study to investigate the effects of NSAIDs on carrageenan-induced paw oedema in rats. Acute inflammation was induced by subplantar injection of carrageenan (0.1 ml, 1 % w/v) into the rat hind paw. Celecoxib (10 mg/kg) caused significant and prolong inhibition of rat paw oedema up to four hours. Treatment of rats with ketoprofen (1 mg/kg) significantly suppressed paw oedema volume at 2, 3 and 4 hour. Meloxicam at (0.2 mg/kg) also significantly inhibited paw oedema at first three hours. Rofecoxib (10 mg/kg) was only effective in inhibiting the paw oedema volume at 2 and 3 hours. |
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