Air pollutants exposure and frequency of micronuclei (MN) among primary school children nearby industrial area
Introduction: Air pollutants that possessed genotoxic properties have the potential to induce genetic damage. Micronuclei (MN) frequency is used as an indicator for identifying potential genotoxic exposures. A comparative cross-sectional study was carried out among primary school children in a petro...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/66155/1/2018120408575208_MJMHS_SP_Nov_2018.pdf |
| _version_ | 1825933078917283840 |
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| author | Muhamad Daud, Siti Aishah Jalaludin, Juliana Sopian, Nor Ashikin |
| author_facet | Muhamad Daud, Siti Aishah Jalaludin, Juliana Sopian, Nor Ashikin |
| author_sort | Muhamad Daud, Siti Aishah |
| collection | UPM |
| description | Introduction: Air pollutants that possessed genotoxic properties have the potential to induce genetic damage. Micronuclei (MN) frequency is used as an indicator for identifying potential genotoxic exposures. A comparative cross-sectional study was carried out among primary school children in a petrochemical industrial area (N=111, Kemaman) and a rural (N=65, Dungun) area in Terengganu. Methods: Validated questionnaires were distributed to obtain the respondents’ socio-demographic data, previous exposure and reported respiratory illness. The frequency of micronuclei was assessed in collected buccal mucosa samples of children. The air monitoring was also carried out at 6 selected schools. Results: Results from the statistical analysis carried out showed significant differences with p=0.001 for all parameters assessed between areas, which included ultrafine particles, UFP (z = -4.842), PM2.5 (z = -10.392), PM10 (z= -11.074) NO2 (z = -11.868), SO2 (z = -5.667), relative humidity (z = -5.587). The MN frequency was statistically significant with PM2.5 (χ2= 17.78, p=0.001) and PM10 (χ2= 15.429, p =0.001). The statistical analysis also showed a significant association between UFP and coughing (PR=2.965, 95% CI=1.069-8.225). The multiple logistic regression analysis showed that the main pollutants influencing MN frequencies were UFP and NO2 with UFP (PR=1.877, 95%CI= 1.174-3.002) and NO2 (PR=1.008, 95%CI= 1.001-1.015). Conclusion: This study demonstrated that exposure to air pollutants may increase the risk of respiratory illness and may induce MN formation among children. |
| first_indexed | 2024-03-06T09:51:46Z |
| format | Article |
| id | upm.eprints-66155 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:51:46Z |
| publishDate | 2018 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| record_format | dspace |
| spelling | upm.eprints-661552019-02-11T03:57:36Z http://psasir.upm.edu.my/id/eprint/66155/ Air pollutants exposure and frequency of micronuclei (MN) among primary school children nearby industrial area Muhamad Daud, Siti Aishah Jalaludin, Juliana Sopian, Nor Ashikin Introduction: Air pollutants that possessed genotoxic properties have the potential to induce genetic damage. Micronuclei (MN) frequency is used as an indicator for identifying potential genotoxic exposures. A comparative cross-sectional study was carried out among primary school children in a petrochemical industrial area (N=111, Kemaman) and a rural (N=65, Dungun) area in Terengganu. Methods: Validated questionnaires were distributed to obtain the respondents’ socio-demographic data, previous exposure and reported respiratory illness. The frequency of micronuclei was assessed in collected buccal mucosa samples of children. The air monitoring was also carried out at 6 selected schools. Results: Results from the statistical analysis carried out showed significant differences with p=0.001 for all parameters assessed between areas, which included ultrafine particles, UFP (z = -4.842), PM2.5 (z = -10.392), PM10 (z= -11.074) NO2 (z = -11.868), SO2 (z = -5.667), relative humidity (z = -5.587). The MN frequency was statistically significant with PM2.5 (χ2= 17.78, p=0.001) and PM10 (χ2= 15.429, p =0.001). The statistical analysis also showed a significant association between UFP and coughing (PR=2.965, 95% CI=1.069-8.225). The multiple logistic regression analysis showed that the main pollutants influencing MN frequencies were UFP and NO2 with UFP (PR=1.877, 95%CI= 1.174-3.002) and NO2 (PR=1.008, 95%CI= 1.001-1.015). Conclusion: This study demonstrated that exposure to air pollutants may increase the risk of respiratory illness and may induce MN formation among children. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/66155/1/2018120408575208_MJMHS_SP_Nov_2018.pdf Muhamad Daud, Siti Aishah and Jalaludin, Juliana and Sopian, Nor Ashikin (2018) Air pollutants exposure and frequency of micronuclei (MN) among primary school children nearby industrial area. Malaysian Journal of Medicine and Health Sciences, 14 (SP2). pp. 56-62. ISSN 1675-8544; ESSN: 2636-9346 http://www.medic.upm.edu.my/upload/dokumen/2018120408575208_MJMHS_SP_Nov_2018.pdf |
| spellingShingle | Muhamad Daud, Siti Aishah Jalaludin, Juliana Sopian, Nor Ashikin Air pollutants exposure and frequency of micronuclei (MN) among primary school children nearby industrial area |
| title | Air pollutants exposure and frequency of micronuclei (MN) among primary school children nearby industrial area |
| title_full | Air pollutants exposure and frequency of micronuclei (MN) among primary school children nearby industrial area |
| title_fullStr | Air pollutants exposure and frequency of micronuclei (MN) among primary school children nearby industrial area |
| title_full_unstemmed | Air pollutants exposure and frequency of micronuclei (MN) among primary school children nearby industrial area |
| title_short | Air pollutants exposure and frequency of micronuclei (MN) among primary school children nearby industrial area |
| title_sort | air pollutants exposure and frequency of micronuclei mn among primary school children nearby industrial area |
| url | http://psasir.upm.edu.my/id/eprint/66155/1/2018120408575208_MJMHS_SP_Nov_2018.pdf |
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