Total antioxidant activity and enzymatic inhibition against alpha-amylase, alpha-glucosidase and pancreatic lipase of irradiated Archidendron bubalinum
Introduction: Archidendron bubalinum is an underutilised plant with numerous antioxidant properties and has a great potential to inhibit enzymes linked with diabetes and obesity. Food irradiation is an advanced technology to prolong the lifespan of plant, prevent physical spoilage and eradicate food...
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Format: | Article |
Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2019
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Online Access: | http://psasir.upm.edu.my/id/eprint/68401/1/2019041008272217_MJMHS_Vol_15_SP1.pdf |
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author | Ja'afar, Nor Liyana Chai, Pui Teng Mohd Rosmi, Noor Syafiqa Aqila Rambli, Siti Nur Atiqah Shafie, Nurul Husna Arapoc, Daryl Jesus Bahari, Hasnah |
author_facet | Ja'afar, Nor Liyana Chai, Pui Teng Mohd Rosmi, Noor Syafiqa Aqila Rambli, Siti Nur Atiqah Shafie, Nurul Husna Arapoc, Daryl Jesus Bahari, Hasnah |
author_sort | Ja'afar, Nor Liyana |
collection | UPM |
description | Introduction: Archidendron bubalinum is an underutilised plant with numerous antioxidant properties and has a great potential to inhibit enzymes linked with diabetes and obesity. Food irradiation is an advanced technology to prolong the lifespan of plant, prevent physical spoilage and eradicate food borne disease. Present study was aimed to determine the total antioxidant activity, enzymatic inhibition against alpha-amylase, alpha-glucosidase and pancreatic lipase and the toxicity levels of non-irradiated and irradiated (3, 6, 9 & 12 kGy) hot aqueous extract of A. bubalinum. Methods: The antioxidant ability of the extract was determined by total phenolic content (TPC), total flavanoid content (TFC), Diphenyl-1-Picrylhydrazyl (DPPH), β-carotene assay and ferric reducing antioxidant potential (FRAP) assay. The inhibitory activities were evaluated using α-amylase, α-glucosidase, and pancreatic lipase inhibition as-say. The toxicity levels of A. bubalinum extract were determined using Brine shrimp and Zebra-fish assays. Results: Results showed that irradiated A. bubalinum at 12 kGy demonstrated the highest TFC (448.99 ± 5.02 mg GAE/g), FRAP (2.55 ± 0.40 mmol Fe2+/g) and β-carotene bleaching activity (79.49%). Whereas, non-irradiated A. bubalinum samples expressed the highest TPC (2517.07 ± 15.81 mg GAE/g) and exhibited the lowest IC50 values of α-amylase (31.99 ± 3.15 μg/ml), α-glucosidase (23.40 ± 0.69μg/ml) and pancreatic lipase (32.81 ± 7.96 μg/ml) activity. The toxicity assays also showed no significant different between irradiated and non-irradiated samples. Conclusion: The study suggests that gamma irradiation has the prospective future to increase antioxidant properties and maintaining the enzyme inhibitory activities to preserve the sample of A. bubalinum for commercial purposes. |
first_indexed | 2024-03-06T09:58:32Z |
format | Article |
id | upm.eprints-68401 |
institution | Universiti Putra Malaysia |
language | English |
last_indexed | 2024-03-06T09:58:32Z |
publishDate | 2019 |
publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
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spelling | upm.eprints-684012019-05-10T08:34:36Z http://psasir.upm.edu.my/id/eprint/68401/ Total antioxidant activity and enzymatic inhibition against alpha-amylase, alpha-glucosidase and pancreatic lipase of irradiated Archidendron bubalinum Ja'afar, Nor Liyana Chai, Pui Teng Mohd Rosmi, Noor Syafiqa Aqila Rambli, Siti Nur Atiqah Shafie, Nurul Husna Arapoc, Daryl Jesus Bahari, Hasnah Introduction: Archidendron bubalinum is an underutilised plant with numerous antioxidant properties and has a great potential to inhibit enzymes linked with diabetes and obesity. Food irradiation is an advanced technology to prolong the lifespan of plant, prevent physical spoilage and eradicate food borne disease. Present study was aimed to determine the total antioxidant activity, enzymatic inhibition against alpha-amylase, alpha-glucosidase and pancreatic lipase and the toxicity levels of non-irradiated and irradiated (3, 6, 9 & 12 kGy) hot aqueous extract of A. bubalinum. Methods: The antioxidant ability of the extract was determined by total phenolic content (TPC), total flavanoid content (TFC), Diphenyl-1-Picrylhydrazyl (DPPH), β-carotene assay and ferric reducing antioxidant potential (FRAP) assay. The inhibitory activities were evaluated using α-amylase, α-glucosidase, and pancreatic lipase inhibition as-say. The toxicity levels of A. bubalinum extract were determined using Brine shrimp and Zebra-fish assays. Results: Results showed that irradiated A. bubalinum at 12 kGy demonstrated the highest TFC (448.99 ± 5.02 mg GAE/g), FRAP (2.55 ± 0.40 mmol Fe2+/g) and β-carotene bleaching activity (79.49%). Whereas, non-irradiated A. bubalinum samples expressed the highest TPC (2517.07 ± 15.81 mg GAE/g) and exhibited the lowest IC50 values of α-amylase (31.99 ± 3.15 μg/ml), α-glucosidase (23.40 ± 0.69μg/ml) and pancreatic lipase (32.81 ± 7.96 μg/ml) activity. The toxicity assays also showed no significant different between irradiated and non-irradiated samples. Conclusion: The study suggests that gamma irradiation has the prospective future to increase antioxidant properties and maintaining the enzyme inhibitory activities to preserve the sample of A. bubalinum for commercial purposes. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/68401/1/2019041008272217_MJMHS_Vol_15_SP1.pdf Ja'afar, Nor Liyana and Chai, Pui Teng and Mohd Rosmi, Noor Syafiqa Aqila and Rambli, Siti Nur Atiqah and Shafie, Nurul Husna and Arapoc, Daryl Jesus and Bahari, Hasnah (2019) Total antioxidant activity and enzymatic inhibition against alpha-amylase, alpha-glucosidase and pancreatic lipase of irradiated Archidendron bubalinum. Malaysian Journal of Medicine and Health Sciences, 15 (SP1). pp. 120-128. ISSN 1675-8544; ESSN: 2636-9346 http://www.medic.upm.edu.my/upload/dokumen/2019041008272217_MJMHS_Vol_15_SP1.pdf |
spellingShingle | Ja'afar, Nor Liyana Chai, Pui Teng Mohd Rosmi, Noor Syafiqa Aqila Rambli, Siti Nur Atiqah Shafie, Nurul Husna Arapoc, Daryl Jesus Bahari, Hasnah Total antioxidant activity and enzymatic inhibition against alpha-amylase, alpha-glucosidase and pancreatic lipase of irradiated Archidendron bubalinum |
title | Total antioxidant activity and enzymatic inhibition against alpha-amylase, alpha-glucosidase and pancreatic lipase of irradiated Archidendron bubalinum |
title_full | Total antioxidant activity and enzymatic inhibition against alpha-amylase, alpha-glucosidase and pancreatic lipase of irradiated Archidendron bubalinum |
title_fullStr | Total antioxidant activity and enzymatic inhibition against alpha-amylase, alpha-glucosidase and pancreatic lipase of irradiated Archidendron bubalinum |
title_full_unstemmed | Total antioxidant activity and enzymatic inhibition against alpha-amylase, alpha-glucosidase and pancreatic lipase of irradiated Archidendron bubalinum |
title_short | Total antioxidant activity and enzymatic inhibition against alpha-amylase, alpha-glucosidase and pancreatic lipase of irradiated Archidendron bubalinum |
title_sort | total antioxidant activity and enzymatic inhibition against alpha amylase alpha glucosidase and pancreatic lipase of irradiated archidendron bubalinum |
url | http://psasir.upm.edu.my/id/eprint/68401/1/2019041008272217_MJMHS_Vol_15_SP1.pdf |
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